Low-fluence carbon dioxide laser irradiation of lentigines

Dover, Jeffrey S.

doi:10.1001/archderm.124.8.1219

Cited by 15 publications

(2 citation statements)

References 6 publications

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“…Routine hematoxylin and eosin sections revealed changes similar to those reported previously [6]. Immediately following laser irradiation, keratinocytes became elongated with clumped nuclear chromatin.…”

Section: Hematoxylin and Eosinsupporting

confidence: 82%

“…The injury pattern caused by lasers and electrical damage is not specific. Similar patterns of destruction have been described in injuries with hot water bottles and 0 1989 Alan R. Liss, Inc. Dover et al [6] studied the regenerating epidermis of lentigines treated with low-dose COz laser irradiation for 6 weeks. They found regenerating keratinocytes protruding into the wound from the unaffected lateral edges as early as 24 h after the insult.…”

Section: Introductionmentioning

confidence: 69%

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Keratinocyte protein expression in rapidly regenerating epidermis following laser‐induced thermal injury

Smoller¹,

Dover²,

Hsu³

1989

Lasers Surg Med

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We examined 20 punch biopsies taken from five patients at varying intervals following CO2 laser-induced thermal injury. The regenerating epidermis was studied with monoclonal antibodies AE1 and AE3 (directed against low and high molecular weight keratins), and involucrin, a protein found within the cellular envelope of the most mature keratinocytes. Twenty-four hours following thermal damage, there was extensive spillage of keratins and involucrin into the papillary dermis and disarray of all constituents of the necrotic keratinocytes. Early ingrowth of basaloid keratinocytes weakly expressed AE1. By 1 week, keratinocytes expressed AE1 in varying intensities throughout the epidermis. AE3 was present in its normal distribution, staining all but the most basaloid keratinocytes. Involucrin stained cells deep within the epidermis. Six weeks following the initial injury, the staining pattern within the epidermis had returned to normal. Thus, it appears that the regenerating epidermis produces low molecular weight keratins in cells at all levels and forms premature cellular envelopes, perhaps as a protective measure, before expression of these constituents reverts to the normal pattern. These findings suggest that keratinocyte differentiation in wound-healing following laser-induced thermal injury is similar to that seen in other types of injury. Observed clinical differences may be attributable to differences in keratinocyte proliferative or migratory capabilities.

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Section: Hematoxylin and Eosinsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 69%