Low-energy femoral shaft fractures after long-term alendronate therapy: report of seven cases

Abstract

Until definite evidence is available, alendronate treatment in patients with osteoporosis is not now prohibited by the healthcare authorities, probably because its beneficial influence outweighs the adverse effects. However, this adverse effect deserves attention of medical practitioners; physicians should be alert on alendronate's possible suppressive effect on bone turnover, which in turn may be responsible for the occurrence of femoral fractures.

Vitamin D level and low-energy fracture risk in children and adolescents: a population-based case–control study of 45 cases

“…We defined vitamin D deficiency, which we also called hypovitaminosis D, as a serum level of 20 ng/ml or less, whereas vitamin D insufficiency was defined as a serum level of 25 ng/ml or less following the latest updates of the Endocrine Society [14,15]. 'Low-energy fractures' were defined as those caused by all types of traumas except for accidents involving motor vehicles, bicycles, ski accidents, and all falls from more than the standing height [16][17][18][19][20]. The diagnosis was established in the emergency department after interviewing the patient and their parents/guardians to obtain socio-demographic information, medical history, and injury mechanism.…”

“…‘Low-energy fractures’ were defined as those caused by all types of traumas except for accidents involving motor vehicles, bicycles, ski accidents, and all falls from more than the standing height [16–20]. The diagnosis was established in the emergency department after interviewing the patient and their parents/guardians to obtain socio-demographic information, medical history, and injury mechanism.…”