Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1

Li, Tao; Ren, Xuehua; Li, Tianjiao; Yu, Lan; Teng, Mingming; Zheng, Yi; Lei, Anmin

doi:10.3390/ijms24032579

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Aromatase is expressed in the granulosa cells of preovulatory follicles and the corpus luteum. The cholesterol side‐chain cleavage cytochrome P‐450 (P450scc) and 17 alpha‐hydroxylase cytochrome P450 (P450[17 alpha]) are mainly expressed in the ovarian theca cells, and low levels of CYP17A1 are expressed in granulosa cells and is involved in the catalysis of androgen production (Doody et al, 1990; Li et al, 2023; Xu et al, 2011). β‐hydroxysteroid dehydrogenase (3Beta HSD‐2) converts estrone to estradiol (Emami et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole‐induced polycystic ovary syndrome in the Sprague Dawley rats

Rashid,

Tripathi,

Singh

et al. 2023

Phytotherapy Research

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Polycystic ovary syndrome (PCOS) is most common in women of reproductive age, giving rise to androgen excess and anovulation, leading to infertility and non‐reproductive complications. We explored the ameliorating effect of naringenin in PCOS using the Sprague Dawley (SD) rat model and human granulosa cells. Letrozole‐induced PCOS rats were given either naringenin (50 mg/kg/day) alone or in combination with metformin (300 mg/kg/day), followed by the estrous cycle, hormonal analysis, and glucose sensitivity test. To evaluate the effect of naringenin on granulosa cell (hGC) steroidogenesis, we treated cells with naringenin (2.5 μM) alone or in combination with metformin (1 mM) in the presence of forskolin (10 μM). To determine the steroidogenesis of CYP‐17A1, ‐19A1, and 3βHSD2, the protein expression levels were examined. Treatment with naringenin in the PCOS animal groups increased ovulation potential and decreased cystic follicles and levels of androgens. The expression levels of CYP‐17A1, ‐19A1, and 3βHSD2, were seen restored in the ovary of PCOS SD rats' model and in the human ovarian cells in response to the naringenin. We found an increased expression level of phosphorylated‐AKT in the ovary and hGCs by naringenin. Naringenin improves ovulation and suppress androgens and cystic follicles, involving AKT activation.

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Section: Resultsmentioning

confidence: 99%

Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole‐induced polycystic ovary syndrome in the Sprague Dawley rats

Rashid,

Tripathi,

Singh

et al. 2023

Phytotherapy Research

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Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice

Shamshoum,

Medak,

McKie

et al. 2023

Biomedicine & Pharmacotherapy

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Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling

Wang,

Sun,

Yang

et al. 2023

J Orthop Surg Res

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Background Eccentric muscle contraction can cause muscle damage, which reduces the efficiency of exercise. Previous evidence suggested that Sodium salicylate (SS) could improve the repair of aged muscle. This study intends to investigate whether SS can impact skeletal muscle damage caused by eccentric exercise. Methods Eccentric treadmill exercise was performed to induce muscle damage in mice. Plasma levels of muscle damage markers were estimated. RT-qPCR was employed for detecting mRNA levels of proinflammatory mediators in murine gastrocnemius muscle. Immunofluorescence staining of laminin/DAPI was utilized for quantifying centrally nucleated myofibers in the gastrocnemius muscle. Western blotting was implemented to examine protein levels of mitsugumin 53 (MG53), matrix metalloproteinase (MMP)-2/9, and NF-κB signaling-related markers. Results SS administration reduced muscle damage marker production in the plasma and decreased the levels of proinflammatory mediators, MG53 and MMP-2/9 in mice after exercise. SS alleviated the severity of muscle damage in the gastrocnemius of mice after eccentric exercise. SS blocked NF-κB signaling pathway in the gastrocnemius muscle. Conclusion SS administration ameliorates skeletal muscle damage caused by eccentric exercise in the mouse model.

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Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1

Cited by 3 publications

References 49 publications

Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole‐induced polycystic ovary syndrome in the Sprague Dawley rats

Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole‐induced polycystic ovary syndrome in the Sprague Dawley rats

Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice

Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling

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