Low-Dose Pantoprazole (20mg) is Effective for Treatment of Mild Reflux Oesophagitis

Ramírez-Barba, Éctor Jaime; Dibildox, Miguel; Bernal, Fernando; Abdo, Miguel; Moguel, A; Lopez, L. H.; Fischer, Renate

doi:10.2165/00044011-199918060-00003

Cited by 6 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Healing rates of 63% after 4 weeks and 88% after 8 weeks were achieved with pantoprazole, and 22% and 46% with ranitidine, respectively (‘per‐protocol’ population). Our results corroborate those of several previous studies 12–15,23 . Healing of esophageal lesions was dependent on the initial grade of esophagitis, whereby somewhat lower healing rates were obtained in patients with the more severe reflux esophagitis (grade III) at baseline, as compared with those with moderate reflux esophagitis (grade II Savary–Miller classification).…”

Section: Discussionsupporting

confidence: 91%

“…Our results corroborate those of several previous studies. [12][13][14][15]23 Healing of esophageal lesions was dependent on the initial grade of esophagitis, whereby somewhat lower healing rates were obtained in patients with the more severe reflux esophagitis (grade III) at baseline, as compared with those with moderate reflux esophagitis (grade II Savary-Miller classification). Although this pattern of healing was observed for both treatment groups, superiority of pantoprazole over ranitidine was maintained even when subgroup analysis was made according to the initial grade of severity (Fig.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate

Meneghelli

Boaventura

Moraes-Filho

et al. 2002

Diseases of the Esophagus

View full text Add to dashboard Cite

Patients with reflux esophagitis (grade II or III, Savary-Miller, intention-to-treat, n=256, age range 19-82 years) were randomly assigned to a double-blind, double-dummy treatment with either pantoprazole 40 mg once daily or ranitidine 150 mg twice daily. After 4 weeks, each patient was clinically and endoscopically assessed. Failure to heal required a further 4 weeks of treatment and a new evaluation thereafter. After 4 weeks, healing of lesions was confirmed in 63% (69 out of 109) of patients receiving pantoprazole and in 22% (25 out of 113) receiving ranitidine (P < 0.001, per protocol population). After 8 weeks, the cumulative healing rates were 88% and 46%, respectively (P < 0.001). Complete freedom from esophagitis-related symptoms (acid eructation, heartburn, pain while swallowing) was greater in the pantoprazole than in ranitidine group after 2 and 4 weeks (74% vs. 47%; 87% vs. 52%, respectively, P < 0.001). After 4 weeks, the healing rate was 76% in Helicobacter pylori (Hp)-positive vs. 45% in Hp-negative patients treated with pantoprazole (P < 0.01). The Hp status did not influence healing rates in patients treated with ranitidine. The most frequent adverse events in the pantoprazole group were diarrhea and somnolence (2-3% of patients), and in the ranitidine group, headache, diarrhea, dizziness, increase of liver enzymes and pruritus (2-4% of patients). In conclusion, pantoprazole was more effective than ranitidine in the healing rate and relief from reflux esophagitis-associated symptoms, and Hp infection was associated with higher healing rate during therapy with pantoprazole but not with ranitidine.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate

Meneghelli

Boaventura

Moraes-Filho

et al. 2002

Diseases of the Esophagus

View full text Add to dashboard Cite

show abstract

“…Dosage regimens based on 20 mg/day and 40 mg/day have been described as equivalently effective in preventing relapse of the esophageal condition in patients with reflux esophagitis treated conventionally (4,11) . Previous studies have shown pantoprazole 20 mg/day to be more effective than ranitidine in usual doses, both in healing esophageal lesions and relieving symptoms of reflux esophagitis (3,13) .…”

Section: Discussionmentioning

confidence: 99%

Assessment of effectiveness of different dosage regimens of pantoprazole in controlling symptoms and healing esophageal lesions of patients with mild erosive esophagitis

Moretzsohn

Brito

Reis

et al. 2002

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Background -Gastroesophageal reflux disease is a very common affection, and esophageal involvement is particularly frequent. The means to effectively control symptoms and improve esophageal inflammation in these patients is to reduce esophageal acid exposure. For this purpose, we use gastric proton pump inhibitor, that can suppress gastric acid secretion. Aim -To compare the effectiveness of two different pantoprazole dosage regimens (20 and 40 mg/day), in controlling symptoms and healing esophageal lesions of patients with mild erosive esophagitis. Material and Methods -Fiftyseven patients with endoscopically confirmed mild erosive esophagitis characterized as non-confluent erosions in the distal esophagus, were randomly to be treated either with pantoprazole 20 mg/day (group I, 28 patients) or 40 mg/day (group II, 29 patients) over a period of 4 weeks. After treatment completion, the patients were assessed for clinical and endoscopic outcome, i.e., absence of erosions in distal esophagus and improvement of gastroesophageal reflux symptoms. Results -At the end of the treatment, 73.1% of the patients in group I and 85.7% of the patients in group II had endoscopic improvement. We also observed, that 88.5% of the patients in group I and 92.9% of the patients in group II had complete elimination of heartburn and regurgitation. Conclusion -Pantoprazole dosage regimens of 20 mg/day and 40 mg/day provide equivalent effectiveness in controlling symptoms and healing esophageal lesions of mild esophagitis.

show abstract

Pantoprazole: A new proton pump inhibitor

Jungnickel¹

2000

Clinical Therapeutics

View full text Add to dashboard Cite

Low-Dose Pantoprazole (20mg) is Effective for Treatment of Mild Reflux Oesophagitis

Cited by 6 publications

References 21 publications

Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate

Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate

Assessment of effectiveness of different dosage regimens of pantoprazole in controlling symptoms and healing esophageal lesions of patients with mild erosive esophagitis

Pantoprazole: A new proton pump inhibitor

Contact Info

Product

Resources

About