Arch Dermatol
 1998
DOI: 10.1001/archderm.134.10.1275
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Low-Dose Oral Etoposide Monotherapy in Adult Langerhans Cell Histiocytosis

Peter Helmbold
1
,
Hans-Jürgen Holzhausen2,
Thomas Klapperstück3
et al.
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Cited by 17 publications

(7 citation statements)
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“…In adults, skeletal involvement usually presents with bone pain and spontaneous fractures in skull, ribs, and long bones. For treatment, excision, curettage, and intralesional steroid injection may be used in local lesions and radiotherapy and chemotherapy for systemic disease (11,12). Our case had multiple bone metastases without any symptoms detected by screening bone scintigraphy and PET-CT. Radiotherapy and chemotherapy were instituted for bone lesions.…”
Section: Discussionmentioning
confidence: 83%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In adults, skeletal involvement usually presents with bone pain and spontaneous fractures in skull, ribs, and long bones. For treatment, excision, curettage, and intralesional steroid injection may be used in local lesions and radiotherapy and chemotherapy for systemic disease (11,12). Our case had multiple bone metastases without any symptoms detected by screening bone scintigraphy and PET-CT. Radiotherapy and chemotherapy were instituted for bone lesions.…”
Section: Discussionmentioning
confidence: 83%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This systematic review encompasses 1 original and 121 previously reported adult cases of cutaneous intertriginous LCH (Table S1), 5–107 notably, the largest compilation of these cases in the medical literature. Our review highlights the wealth of case reports and case series in the medical literature documenting this unique clinical presentation.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Single agent etoposide has been used in the treatment of advanced‐stage cancers as well as low‐grade systemic lymphomas, histiocytosis and primary cutaneous large cell lymphomas (Greco, ; Hainsworth, Johnson, Frazier, & Greco, ; Helmbold, Hegemann, Holzhausen, Klapperstuck, & Marsch, ; Rijlaarsdam, Huijgens, Beljaards, Bakels, & Willemze, ). Interestingly, studies showed that prolonged administration of etoposide was more effective than single dose administrations (Greco, ; Slevin et al, ).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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