volume 91, issue 1, P10-16 2010
DOI: 10.1111/j.1365-2613.2009.00684.x
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Fang-Zhen Shen, Jing Wang, Jun Liang, Kun Mu, Ji-Yuan Hou, Yan-Tao Wang

Abstract: Low-dose chemotherapy drugs can suppress tumours by restraining tumour vessel growth and preventing the repair of damaged vascular endothelial cells. Cisplatin is a broad-spectrum, cell cycle-non-specific drug, but has serious side effects if used at high doses. There have been few reports on the anti-angiogenic effects of low-dose cisplatin and hence the effect of low-dose metronomic (LDM) chemotherapy on the proliferation and neovascularization of H22 hepatocarcinoma cells is discussed in this research. The …

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