Low-dose aspirin for in vitro fertilisation

What do consistently high-performing in vitro fertilization programs in the U.S. do?

“…There are also many practices that are not common among high-performing programs (e.g., use of low-dose aspirin or metformin during stimulation, use of assisted hatching, use of diazepam before ET, use of estrogen supplementation after ET). Many of these practices are not evidence based, and our findings suggest that these practices are not essential for IVF programs, in general, to have excellent outcomes (9)(10)(11)(12). However, it cannot be ruled out that a given clinical practice, although uncommonly used in many centers, could be critical to an individual program's success.…”

What do consistently high-performing in vitro fertilization programs in the U.S. do?

“…There are also many practices that are not common among high-performing programs (e.g., use of low-dose aspirin or metformin during stimulation, use of assisted hatching, use of diazepam before ET, use of estrogen supplementation after ET). Many of these practices are not evidence based, and our findings suggest that these practices are not essential for IVF programs, in general, to have excellent outcomes (9)(10)(11)(12). However, it cannot be ruled out that a given clinical practice, although uncommonly used in many centers, could be critical to an individual program's success.…”

Live birth rates after combined adjuvant therapy in IVF–ICSI cycles: a matched case-control study

“…Five meta-analyses have been published on the subject thus far, with most showing no beneficial effect of aspirin. Three of these meta-analyses (Gelbaya et al, 2007;Khairy et al, 2007;Poustie et al, 2007) reported no significant effect of aspirin. The fourth conventional meta-analysis (Ruopp et al, 2008) suggested a statistically significant effect of aspirin with an OR of 1.2 (95% CI 1.1 to 1.4).…”

Low-dose aspirin in non-tubal IVF patients with previous failed conception: a prospective randomized double-blind placebo-controlled trial

“…Since the appearance of positive reports on aspirin use in patients with tubal infertility (6), several studies have analyzed the potential benefit for the IVF patient population (9)(10)(11)(12)(13)(14). There is large heterogeneity among these studies (19), possibly because most of the studies had selected different patient groups and used different periods of aspirin administration. Moreover, a number of these studies did not present sample size calculations, and when there was a sample size calculation this number was not always reached.…”

“…Recently, a Cochrane review (19) found no significant improvement in pregnancy rates when IVF was combined with low-dose aspirin administration. The authors suggested that women with a history of implantation failure or unexplained subfertility would be subgroups worthy of further investigation.…”

What do consistently high-performing in vitro fertilization programs in the U.S. do?

“…There are also many practices that are not common among high-performing programs (e.g., use of low-dose aspirin or metformin during stimulation, use of assisted hatching, use of diazepam before ET, use of estrogen supplementation after ET). Many of these practices are not evidence based, and our findings suggest that these practices are not essential for IVF programs, in general, to have excellent outcomes (9)(10)(11)(12). However, it cannot be ruled out that a given clinical practice, although uncommonly used in many centers, could be critical to an individual program's success.…”

Live birth rates after combined adjuvant therapy in IVF–ICSI cycles: a matched case-control study

“…Five meta-analyses have been published on the subject thus far, with most showing no beneficial effect of aspirin. Three of these meta-analyses (Gelbaya et al, 2007;Khairy et al, 2007;Poustie et al, 2007) reported no significant effect of aspirin. The fourth conventional meta-analysis (Ruopp et al, 2008) suggested a statistically significant effect of aspirin with an OR of 1.2 (95% CI 1.1 to 1.4).…”

Low-dose aspirin in non-tubal IVF patients with previous failed conception: a prospective randomized double-blind placebo-controlled trial

“…Since the appearance of positive reports on aspirin use in patients with tubal infertility (6), several studies have analyzed the potential benefit for the IVF patient population (9)(10)(11)(12)(13)(14). There is large heterogeneity among these studies (19), possibly because most of the studies had selected different patient groups and used different periods of aspirin administration. Moreover, a number of these studies did not present sample size calculations, and when there was a sample size calculation this number was not always reached.…”

“…Recently, a Cochrane review (19) found no significant improvement in pregnancy rates when IVF was combined with low-dose aspirin administration. The authors suggested that women with a history of implantation failure or unexplained subfertility would be subgroups worthy of further investigation.…”

What do consistently high-performing in vitro fertilization programs in the U.S. do?

“…There are also many practices that are not common among high-performing programs (e.g., use of low-dose aspirin or metformin during stimulation, use of assisted hatching, use of diazepam before ET, use of estrogen supplementation after ET). Many of these practices are not evidence based, and our findings suggest that these practices are not essential for IVF programs, in general, to have excellent outcomes (9)(10)(11)(12). However, it cannot be ruled out that a given clinical practice, although uncommonly used in many centers, could be critical to an individual program's success.…”

Live birth rates after combined adjuvant therapy in IVF–ICSI cycles: a matched case-control study

“…Five meta-analyses have been published on the subject thus far, with most showing no beneficial effect of aspirin. Three of these meta-analyses (Gelbaya et al, 2007;Khairy et al, 2007;Poustie et al, 2007) reported no significant effect of aspirin. The fourth conventional meta-analysis (Ruopp et al, 2008) suggested a statistically significant effect of aspirin with an OR of 1.2 (95% CI 1.1 to 1.4).…”

Low-dose aspirin in non-tubal IVF patients with previous failed conception: a prospective randomized double-blind placebo-controlled trial

“…Since the appearance of positive reports on aspirin use in patients with tubal infertility (6), several studies have analyzed the potential benefit for the IVF patient population (9)(10)(11)(12)(13)(14). There is large heterogeneity among these studies (19), possibly because most of the studies had selected different patient groups and used different periods of aspirin administration. Moreover, a number of these studies did not present sample size calculations, and when there was a sample size calculation this number was not always reached.…”

“…Recently, a Cochrane review (19) found no significant improvement in pregnancy rates when IVF was combined with low-dose aspirin administration. The authors suggested that women with a history of implantation failure or unexplained subfertility would be subgroups worthy of further investigation.…”