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Cited by 60 publications
(47 citation statements)
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References 33 publications
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“…Furthermore, consistent with our results demonstrating reduced HCRU following belimumab initiation, several studies have reported reduced HCRU34 and/or reduced SLE disease activity in the postbelimumab versus the prebelimumab periods 34–37. This was demonstrated by reduced SLE Disease Activity Index (SLEDAI) score,35 37–42 improved overall clinical response,34 39 43 a reduced proportion of patients with moderate to severe disease,34 reduced flare rate38 40 and reductions in common SLE manifestations 37. Furthermore, a range of studies showed decreased oral corticosteroid use following belimumab initiation 34 37–40 42 43…”
Section: Discussionsupporting
confidence: 87%
“…Furthermore, consistent with our results demonstrating reduced HCRU following belimumab initiation, several studies have reported reduced HCRU34 and/or reduced SLE disease activity in the postbelimumab versus the prebelimumab periods 34–37. This was demonstrated by reduced SLE Disease Activity Index (SLEDAI) score,35 37–42 improved overall clinical response,34 39 43 a reduced proportion of patients with moderate to severe disease,34 reduced flare rate38 40 and reductions in common SLE manifestations 37. Furthermore, a range of studies showed decreased oral corticosteroid use following belimumab initiation 34 37–40 42 43…”
Section: Discussionsupporting
confidence: 87%
“…After initial demonstration in a single-center cohort that LLDAS attainment was associated with protection from flare and irreversible organ damage accrual 10 , studies followed that showed that LLDAS attainment is associated with improved health-related quality of life, and has superior performance characteristics to expert opinion unguided by a definition 12,13 . Importantly, the finding that attainment of LLDAS is associated with protection from organ damage accrual has been repeated in multiple other independent cohorts, in Europe and North America 14,15,16,17,18 , with a remarkably consistent finding that 50% of observed time in LLDAS results in a 50% reduction in damage accrual. The most intensive evaluation of Definition of Remission in SLE (DORIS) 11 so far was published by Petri and Magder in 2018, wherein it was demonstrated that remission attainment was highly protective from damage accrual, and that this protection was achieved at a lower exposure than was the case for LLDAS 15 .…”
mentioning
confidence: 74%
“…The term "Physician Global Assessment" (PGA) was coined in 1991 by Petri et al (9) to address a disease activity index scored on a VAS ranging from 0 to 3, with an increase of ≥ 1.0 since the last visit indicating a flare. Subsequently, the PGA was incorporated in the SELENA flare index in 1999 (10), in the Systemic Responder Index in 2009 (3,(11)(12) as well as in the definitions of low disease activity (LLDAS) (13) and various definitions of remission (14)(15).…”
Section: Introductionmentioning
confidence: 99%