1999
DOI: 10.1515/cclm.1999.114
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Abstract: The bone mineral density (BMD) and the associated extracellular status of mineral and acid-base metabolism were evaluated in 11 males, 3-18 years after total gastrectomy (GX). In the lumbar spine, but not in the femoral neck, BMD was decreased in seven, normal in three, and falsely high in one individual. Relative to the limits of normalcy, fasting serum levels of gastrin were low, but normal for calcium, phosphorus, parathyroid hormone, calcitonin and vitamin D, while the level of total alkaline phosphatase w… Show more

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Cited by 15 publications
(7 citation statements)
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“…It is consistent with other studies that trabecular bone was more affected than cortical bone after gastrectomy [7,8] . In other DXA-based studies in post-gastrectomy patients, the prevalence of spinal osteoporosis was 22%-37% and the prevalence of femoral neck osteoporosis was 10%-61% [9][10][11] . In the present study, 24 patients (18.0%) reported osteoporotic fracture with severe pain, such as Colles', ankle and severe vertebral fractures.…”
Section: Discussionmentioning
confidence: 76%
See 1 more Smart Citation
“…It is consistent with other studies that trabecular bone was more affected than cortical bone after gastrectomy [7,8] . In other DXA-based studies in post-gastrectomy patients, the prevalence of spinal osteoporosis was 22%-37% and the prevalence of femoral neck osteoporosis was 10%-61% [9][10][11] . In the present study, 24 patients (18.0%) reported osteoporotic fracture with severe pain, such as Colles', ankle and severe vertebral fractures.…”
Section: Discussionmentioning
confidence: 76%
“…Following gastric resection, reduced cortical and trabecular bone mass have been reported, however, the mechanism remains unclear [5,6] . The american Gastroenterological Association (AGA) has recommended dual-energy X-ray absorptiometry (DXA) in patients who are alive at least 10 years after gastrectomy [6] , based on many reports of post-gastrectomy bone disease [7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Most studies have dealt with patients with peptic ulcer disease, and those focusing on gastric cancer patients are rare.…”
Section: Introductionmentioning
confidence: 99%
“…The investigated vitamin D metabolites were 25(OH)D (11 studies) [14,[17][18][19]21,[23][24][25][26]28,31], 1,25(OH) 2 D (6 studies) [14,17,24,25,27,31], and 24,25(OH) 2 D (2 studies) [24,31]. Six studies did not report the investigated metabolite [15,16,20,22,29,30], declaring that they analyzed "serum vitamin D". The other concomitant and most frequently analyzed parameters were bone mineral density (nine studies) [14,16,17,[19][20][21]23,26,30], serum estradiol level (three studies) [14,17,25] and other bone metabolism biomarkers, as part of the studies focused on bone density and risk of osteoporosis after gastric cancer surgery with vitamin D and its metabolites evaluated only as indicators.…”
Section: Rino Y Et Al [27] 16 Patientsmentioning
confidence: 99%
“…2B). Although the true acid-base status of bone was not investigated either in the present work on FX or in our previous experimental animal [25][26][27] and clinical [28] work, the sequelae of removal of gastric acidproducing tissue and the associated changes in bone raise questions; they have led others to an attractive hypothesis [4]. If according to this hypothesis, bone is in fact a sink for protons, we now propose the following sequence: once phosphorus is extruded from bone, circulating phosphorus and protons will be filtered in excess by renal glomeruli, and combine inside renal tubular lumen with hypersecreted protons to monovalent phosphate -a poorly reabsorbable anion [17]; as a result hyperphosphaturia develops, while the decrease in urinary pH may be only moderate ( Table 2).…”
Section: Integrated View Of Abnormalitiesmentioning
confidence: 99%