2021
DOI: 10.3390/nu13093021
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Abstract: We evaluated associations between serum 25-hydroxyvitamin D [25(OH)D] level and severity of new coronavirus infection (COVID-19) in hospitalized patients. We assessed serum 25(OH)D level in 133 patients aged 21–93 years. Twenty-five (19%) patients had severe disease, 108 patients (81%) had moderate disease, and 18 (14%) patients died. 25(OH)D level ranged from 3.0 to 97.0 ng/mL (median, 13.5 [25%; 75%, 9.6; 23.3] ng/mL). Vitamin D deficiency was diagnosed in 90 patients, including 37 with severe deficiency. In… Show more

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Cited by 22 publications
(13 citation statements)
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“…Vitamin D is postulated to play an important immunomodulatory role, and deficiency is associated with increased incidence of ARVI, including COVID-19 [ 26 , 27 , 28 ]. Our previous results also showed that severe vitamin D deficiency is associated with severity and death in COVID-19 patients [ 29 ], and were comparable to recent findings [ 4 , 30 ]. Dissanayake and colleagues, whose meta-analysis included 72 COVID-19 observational and 4 interventional randomized studies, have shown not only correlations between 25(OH)D level and severity or mortality, but also some clinical benefits and improvement in inflammatory markers of vitamin D supplementation in treating COVID-19 [ 22 ].…”
Section: Discussionsupporting
confidence: 92%
“…Vitamin D is postulated to play an important immunomodulatory role, and deficiency is associated with increased incidence of ARVI, including COVID-19 [ 26 , 27 , 28 ]. Our previous results also showed that severe vitamin D deficiency is associated with severity and death in COVID-19 patients [ 29 ], and were comparable to recent findings [ 4 , 30 ]. Dissanayake and colleagues, whose meta-analysis included 72 COVID-19 observational and 4 interventional randomized studies, have shown not only correlations between 25(OH)D level and severity or mortality, but also some clinical benefits and improvement in inflammatory markers of vitamin D supplementation in treating COVID-19 [ 22 ].…”
Section: Discussionsupporting
confidence: 92%
“…They determined that 25(OH)D < 12 ng/mL was significantly associated with 2.58-fold (95% CI, 1.01, 6.62) increased risk of COVID-19 mortality following adjustment for age, comorbidities or sex ( p = 0.048). Indeed, Karanova et al [ 5 ] presents further data in accordance with AlSafar et al [ 4 ], which supports the notion that 25(OH)D deficiency is common among hospitalized COVID-19 patients. In their study, 90 out of 133 Russian COVID-19 patients were either 25(OH)D deficient or insufficient.…”
supporting
confidence: 60%
“…In their study, 90 out of 133 Russian COVID-19 patients were either 25(OH)D deficient or insufficient. Karanova et al [ 5 ] also determined that 25(OH)D levels between approximately 11–12 ng/mL was the threshold value for increased risk of severe COVID-19 disease and mortality. Both studies add to a growing literature demonstrating that having sufficient 25(OH)D levels may be of critical importance and a predictor of coronavirus patient outcomes.…”
mentioning
confidence: 99%
“…Recent studies demonstrated that a low 25(OH)D level is considered as an independent risk factor for COVID-19 severity [ 7 , 8 , 9 , 10 , 11 ]. Previously, we showed an association between severe vitamin D deficiency and outcomes in patients with COVID-19 [ 12 ]. The results of the meta-analysis that included several observational studies with data for approximately two million adults suggested that vitamin D deficiency/insufficiency increased the susceptibility to COVID-19 and its severity.…”
Section: Introductionmentioning
confidence: 99%