J. Neurosci. Res. volume 86, issue 1, P71-83 2007 DOI: 10.1002/jnr.21474 View full text
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Armando Cardoso, Marco Assunção, José P. Andrade, Pedro A. Pereira, M. Dulce Madeira, Manuel M. Paula-Barbosa, Nikolai V. Lukoyanov

Abstract: The goal of this study was to answer the question of whether repeated administration of electroconvulsive shock (ECS) seizures causes structural changes in the entorhinal-dentate projection system, whose neurons are known to be particularly vulnerable to seizure activity. Adult rats were administered six ECS seizures, the first five of which were spaced by 24-hr intervals, whereas the last two were only 2 hr apart. Stereological approaches were employed to compare the total neuronal and synaptic numbers in sha…

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