Loss of sensory function in patients with idiopathic hand dystonia

Suttrup, Inga; Oberdiek, Denise; Suttrup, Judith; Osada, Nani; Evers, Stefan; Marziniak, Martin

doi:10.1002/mds.23425

Cited by 33 publications

(21 citation statements)

References 36 publications

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“…Before starting the study a sample size estimation was performed, based on an estimated reduction of amplitude of 30% and a power of 80%, which suggested a sample size of 22. The calculation was based on the CHEPs data of Suttrup et al [22]. The diagnosis was made according to the criteria of the International Classification of Headache Disorders 2 nd edition [23].…”

Section: Methodsmentioning

confidence: 99%

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Contact heat evoked potentials and habituation measured interictally in migraineurs

et al. 2015

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BackgroundA lack of habituation of different evoked potential modalities in migraine patients in-between attacks has been suggested.MethodsThis study investigates cortical response after painful stimuli evaluated by contact heat evoked potentials (CHEPs) and quantitative sensory testing (QST) during the migraine-free interval. We enrolled 22 migraine patients and 22 healthy subjects.ResultsCortical potentials after contact heat stimulation of the cheeks and the volar forearm at a temperature of 51°C showed significantly reduced A-δ-amplitudes in patients and healthy controls. When the subjects’ attention was drawn to an arithmetic task, a partial lack of habituation of amplitude could be seen in migraine patients. QST did not show any difference between migraineurs and controls.ConclusionOur findings can be primarily deemed to demonstrate that patients and healthy controls show significantly lower amplitudes while performing the calculation task. Without performing the calculation task we could not show the expected lack of habituation in migraineurs. Yet, while performing the calculation task our results partly suggest that hypothesis.

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Section: Methodsmentioning

confidence: 99%

“…A similar setting and the same methods of QST and CHEPs have been used in a study examining idiopathic dystonia [22]. …”

Section: Methodsmentioning

confidence: 99%

Contact heat evoked potentials and habituation measured interictally in migraineurs

et al. 2015

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“…Recording of contact heat-evoked potentials in response to heat stimulation of the volar forearm and the dorsum of the hand at a temperature of 51°C in patients with focal hand dystonia showed lower N2–P2 amplitudes in the somatosensory cortex from the dystonic arm than in the unaffected side and healthy controls. 96 Additionally, on quantitative sensory testing, increased thresholds of thermal detection and mechanical pain, and decreased mechanical pain sensitivity on the affected limb, suggest a loss of sensory function of the dystonic hand. This study indicates the potential contribution of the small-fibre A-δ-system, which underlies transmission of the thermal stimuli to the pathophysiology of dystonia.…”

Section: Dystoniamentioning

confidence: 99%

Sensory aspects of movement disorders

Patel¹,

Jankovic²,

Hallett³

2014

The Lancet Neurology

306

200

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Movement disorders, which include disorders such as Parkinson’s disease, dystonia, Tourette’s syndrome, restless legs syndrome, and akathisia, have traditionally been considered to be disorders of impaired motor control resulting predominantly from dysfunction of the basal ganglia. This notion has been revised largely because of increasing recognition of associated behavioural, psychiatric, autonomic, and other non-motor symptoms. The sensory aspects of movement disorders include intrinsic sensory abnormalities and the effects of external sensory input on the underlying motor abnormality. The basal ganglia, cerebellum, thalamus, and their connections, coupled with altered sensory input, seem to play a key part in abnormal sensorimotor integration. However, more investigation into the phenomenology and physiological basis of sensory abnormalities, and about the role of the basal ganglia, cerebellum, and related structures in somatosensory processing, and its effect on motor control, is needed.

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“…The condition frequently results in co-contraction of wrist flexors and extensors and in involuntary curling, or extending of digits, thus rendering fast movements involved for example in scale playing irregular (Jabusch et al, 2004). It is known that focal hand dystonia involves several sensory abnormalities, such as reduced two-point discrimination thresholds, reduced graphaesthesia (Byl et al, 1996), and an impairment of the thermal detection thresholds (Suttrup et al, 2011). Furthermore, temporal judgment of somatosensory and auditory stimuli has been shown to be altered in musicians suffering from dystonia (Lim et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Altered sensory feedbacks in pianist's dystonia: the altered auditory feedback paradigm and the glove effect

Cheng¹,

Großbach²,

Altenmüller³

2013

Front. Hum. Neurosci.

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Background: This study investigates the effect of altered auditory feedback (AAF) in musician's dystonia (MD) and discusses whether AAF can be considered as a sensory trick in MD. Furthermore, the effect of AAF is compared with altered tactile feedback, which can serve as a sensory trick in several other forms of focal dystonia.Methods: The method is based on scale analysis (Jabusch et al., 2004). Experiment 1 employs synchronization paradigm: 12 MD patients and 25 healthy pianists had to repeatedly play C-major scales in synchrony with a metronome on a MIDI-piano with three auditory feedback conditions: (1) normal feedback; (2) no feedback; (3) constant delayed feedback. Experiment 2 employs synchronization-continuation paradigm: 12 MD patients and 12 healthy pianists had to repeatedly play C-major scales in two phases: first in synchrony with a metronome, secondly continue the established tempo without the metronome. There are four experimental conditions, among them three are the same AAF as in Experiment 1 and 1 is related to altered tactile sensory input. The coefficient of variation of inter-onset intervals of the key depressions was calculated to evaluate fine motor control.Results: In both experiments, the healthy controls and the patients behaved very similarly. There is no difference in the regularity of playing between the two groups under any condition, and neither did AAF nor did altered tactile feedback have a beneficial effect on patients' fine motor control.Conclusions: The results of the two experiments suggest that in the context of our experimental designs, AAF and altered tactile feedback play a minor role in motor coordination in patients with musicians' dystonia. We propose that altered auditory and tactile feedback do not serve as effective sensory tricks and may not temporarily reduce the symptoms of patients suffering from MD in this experimental context.

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Loss of sensory function in patients with idiopathic hand dystonia

Cited by 33 publications

References 36 publications

Contact heat evoked potentials and habituation measured interictally in migraineurs

Contact heat evoked potentials and habituation measured interictally in migraineurs

Sensory aspects of movement disorders

Altered sensory feedbacks in pianist's dystonia: the altered auditory feedback paradigm and the glove effect

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