2016
DOI: 10.18632/aging.101006
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in patients with cancer (weight-stable (CWS) or weight-losing (CWL)) or healthy elderly (HE) when compared with healthy middle-aged controls (HMA). 28 patients with cancer (CWS: 18 and CWL: 10), HE: 21 and HMA: 20 under… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
21
0
1

Year Published

2017
2017
2020
2020

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 33 publications
(23 citation statements)
references
References 30 publications
(40 reference statements)
1
21
0
1
Order By: Relevance
“…In this regard, in the muscle of tumour‐bearing animals, satellite cells (SCs) increase in number and accumulate in the interstitial space among the fibres . The same pattern has been observed also in cancer patients . From the mechanistic point of view, activation of NF‐κB in myogenic progenitors has been pointed as responsible for a persistent up‐regulation of PAX7, thus blocking the expression of transcription factors important for SC differentiation .…”
Section: Introductionmentioning
confidence: 81%
“…In this regard, in the muscle of tumour‐bearing animals, satellite cells (SCs) increase in number and accumulate in the interstitial space among the fibres . The same pattern has been observed also in cancer patients . From the mechanistic point of view, activation of NF‐κB in myogenic progenitors has been pointed as responsible for a persistent up‐regulation of PAX7, thus blocking the expression of transcription factors important for SC differentiation .…”
Section: Introductionmentioning
confidence: 81%
“…D'Souza et al . postulated a supportive role of miR‐451a in myogenesis, and its decreased expression observed in our study may relate to impairments in the myogenesis process, which have been implicated in cancer cachexia …”
Section: Discussionmentioning
confidence: 51%
“…The High Capacity cDNA reverse transcription kit (Applied Biosystems; Thermo Fisher Scientific, Inc.) was used to convert 1 µ g of RNA to cDNA following the manufacturer's instructions. The quantitative validation of the expression of selected genes was performed by RT-qPCR, as previously described ( 35 ). In detail, the Applied Biosystems StepOne real-time PCR system was applied using custom PrimerDesign primers (Primerdesign Ltd., Chandler's Ford, UK) and the SYBR-Green PCR master mix (cat.…”
Section: Methodsmentioning
confidence: 99%