Abstract:Acute promyelocytic leukemia (APL) is characterized by the chromosomal translocation t(15;17) which results in the expression of the chimeric protein PML- RARα. Compared to the wild type retinoic acid receptor α (RARα), the fusion protein acquires dominant oncogenic properties and the chromosomal rearrangement is identified as the trigger of APL. However the pathogenesis of APL cannot be explained by the sole failure of RARα regulation and additional genetic and epigenetic alterations are required. We and othe… Show more
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