Loss of heterozygosity at 13q14 correlates withRB1 gene underexpression in human breast cancer

Alterations of the retinoblastoma gene in metastatic breast cancer

“…We found the frequency of reduced RB1 gene copy number to be lower among the metastatic lesions as compared to what has been reported by others [14, 21, 22] as well as our own results reporting on non-matching primary breast cancer [15]. This may seem as a paradox, since deletion of a tumor suppressor in theory should provide cells with growth advantages and support tumor progression (“driver”).…”

Alterations of the retinoblastoma gene in metastatic breast cancer

“…We found the frequency of reduced RB1 gene copy number to be lower among the metastatic lesions as compared to what has been reported by others [14, 21, 22] as well as our own results reporting on non-matching primary breast cancer [15]. This may seem as a paradox, since deletion of a tumor suppressor in theory should provide cells with growth advantages and support tumor progression (“driver”).…”

Genetic mutations in HER2-positive breast cancer: possible association with response to trastuzumab therapy

“…RB1 is a tumor suppressor gene that is mutated in several types of cancer [ 53 ]. RB1 gene under-expression was actually reported to promote breast carcinogenesis [ 54 ]. Moreover, RB pathway is frequently altered in HER2+ tumors [ 55 ].…”

SKY analysis revealed recurrent numerical and structural chromosome changes in BDII rat endometrial carcinomas

“…RNO15 is homologous to segments of human chromosomes 10q, 6p, 3p, 14q, 8p, and 13q, some of which are reported to exhibit loss of heterozygosity and deletions in human endometrial cancers [33-35] and in other human cancer types [36]. There are a number of important cancer-related genes located on this chromosome, including Anxa7 (annexin 7, its human counterpart ANXA7 located on HSA10q21), which is a tumor suppressor gene associated with prostate cancer [37] and Bmp4 , Lgals3 and Cdkn3 , whose human counterparts are located on chromosome band 14q22 in human.…”

Alterations of the retinoblastoma gene in metastatic breast cancer

“…We found the frequency of reduced RB1 gene copy number to be lower among the metastatic lesions as compared to what has been reported by others [14, 21, 22] as well as our own results reporting on non-matching primary breast cancer [15]. This may seem as a paradox, since deletion of a tumor suppressor in theory should provide cells with growth advantages and support tumor progression (“driver”).…”

Genetic mutations in HER2-positive breast cancer: possible association with response to trastuzumab therapy

“…RB1 is a tumor suppressor gene that is mutated in several types of cancer [ 53 ]. RB1 gene under-expression was actually reported to promote breast carcinogenesis [ 54 ]. Moreover, RB pathway is frequently altered in HER2+ tumors [ 55 ].…”

SKY analysis revealed recurrent numerical and structural chromosome changes in BDII rat endometrial carcinomas

“…RNO15 is homologous to segments of human chromosomes 10q, 6p, 3p, 14q, 8p, and 13q, some of which are reported to exhibit loss of heterozygosity and deletions in human endometrial cancers [33-35] and in other human cancer types [36]. There are a number of important cancer-related genes located on this chromosome, including Anxa7 (annexin 7, its human counterpart ANXA7 located on HSA10q21), which is a tumor suppressor gene associated with prostate cancer [37] and Bmp4 , Lgals3 and Cdkn3 , whose human counterparts are located on chromosome band 14q22 in human.…”

Alterations of the retinoblastoma gene in metastatic breast cancer

“…We found the frequency of reduced RB1 gene copy number to be lower among the metastatic lesions as compared to what has been reported by others [14, 21, 22] as well as our own results reporting on non-matching primary breast cancer [15]. This may seem as a paradox, since deletion of a tumor suppressor in theory should provide cells with growth advantages and support tumor progression (“driver”).…”

Genetic mutations in HER2-positive breast cancer: possible association with response to trastuzumab therapy

“…RB1 is a tumor suppressor gene that is mutated in several types of cancer [ 53 ]. RB1 gene under-expression was actually reported to promote breast carcinogenesis [ 54 ]. Moreover, RB pathway is frequently altered in HER2+ tumors [ 55 ].…”

SKY analysis revealed recurrent numerical and structural chromosome changes in BDII rat endometrial carcinomas

“…RNO15 is homologous to segments of human chromosomes 10q, 6p, 3p, 14q, 8p, and 13q, some of which are reported to exhibit loss of heterozygosity and deletions in human endometrial cancers [33-35] and in other human cancer types [36]. There are a number of important cancer-related genes located on this chromosome, including Anxa7 (annexin 7, its human counterpart ANXA7 located on HSA10q21), which is a tumor suppressor gene associated with prostate cancer [37] and Bmp4 , Lgals3 and Cdkn3 , whose human counterparts are located on chromosome band 14q22 in human.…”