Loss of H2 Histamine Receptor Activity in Rabbit Aorta after Maturity

Holl, J E; Mokler, Corwin M.

doi:10.1097/00005344-198201000-00022

Cited by 10 publications

(5 citation statements)

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“…The data on this relationship are limited; hence, further research is warranted. The H 2 R-induced relaxation of isolated aortic strips using dimaprit as an agonist was greatly attenuated in mature rabbits (6–7 months of age) compared to young rabbits (6 weeks of age) ( Holl and Mokler 1982 ). A contrasting finding was reported in strips isolated from coronary arteries in dogs.…”

Section: Cardiovascular H 2 -Histamine Receptors and Ageingmentioning

confidence: 99%

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Neumann¹,

Kirchhefer²,

Dhein³

et al. 2021

Front. Pharmacol.

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This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H2-histamine-receptors in cardiac diseases will be examined. The use of H2-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H2-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H2-histamine receptor antagonists in treating chronic heart failure in animal models and patients will be reviewed. Some limitations in our biochemical understanding of the cardiac role of H2-histamine receptors will be discussed. Recommendations for further basic and translational research on cardiac H2-histamine receptors will be offered. We will speculate whether new knowledge might lead to novel roles of H2-histamine receptors in cardiac disease and whether cardiomyocyte specific H2-histamine receptor agonists and antagonists should be developed.

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Section: Cardiovascular H 2 -Histamine Receptors and Ageingmentioning

confidence: 99%

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Neumann¹,

Kirchhefer²,

Dhein³

et al. 2021

Front. Pharmacol.

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“…Maturation and aging are associated with alterations in respon siveness to a wide variety of hormones (1,2,3). Recent progress has been made towards understanding the basis of these changes at the receptor level (2) and Chen et al have shown a dissociation between the appearance of receptors detectable by radioligand binding and their coupling to functional response in the mouse heart (4).…”

Section: Introductionmentioning

confidence: 99%

Maternal and Fetal Platelet Responses and Adrenoceptor Binding Characteristics

et al. 1985

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SummaryPaired blood samples were obtained from mothers (venous) and babies (cord venous blood) at the time of delivery by caesarean section under epidural anaesthetic. Fetal platelets failed to aggregate in response to adrenaline in vitro although adrenaline could potentiate the threshold response to adenosine diphosphate (1 μM). Fetal platelet responses to collagen and 8 Arg vasopressin did not differ significantly from maternal responses. Maternal and fetal platelets also showed similar inhibition of aggregation after activation of adenylate cyclase (PGE1 and parathormone), in contrast to the inhibition of adenylate cyclase by adrenaline.Alpha2 adrenoceptors were investigated using [3H] yohimbine binding receptor number and were reduced modestly but significantly on fetal compared to maternal platelets. The failure of fetal platelet aggregation in response to adrenaline appears to be related to a failure of receptor coupling and may represent a delayed maturation of fetal platelet alpha receptors or a response- to increased circulating catecholamines during birth.

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“…Despite the fact that PGI2-induced relaxations did not alter significantly with age, relaxations induced by histamine were related directly to age from 30 days to 2 years. H2receptor activity in the rabbit aorta is reportedly diminished as the animal matures (Holl & Mokler, 1982). If this is true in the case of beagle mesenteric arteries, it may be concluded that the release of PGI2 by histamine from the arterial wall is increased with advancing age, and PGI2 in an amount sufficient to mask the contractile action of histamine on arterial smooth muscle is not released in the infant beagle arteries.…”

Section: Discussionmentioning

confidence: 99%

Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle

Shimizu

Toda

1986

British J Pharmacology

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1 Responses to vasodilator agents were compared in helical strips ofmesenteric arteries from beagles of different ages (30 days, 3 months, 2 years and 12 years old), precontracted with prostaglandin F2% (PGFu). Relaxations induced by isoprenaline and adenosine were related inversely to age, whereas those induced by PGI2 and K+ (5 mM) did not alter with age. 2 Acetylcholine-induced relaxations were less in the arteries from the aged (12 year old) beagles than in those from the younger beagles. Histamine-induced relaxations related directly to age between 30 days and 2 years. Acetylcholine-induced relaxation was reversed to a contraction in infant (30 day old) beagle arteries by removal of the endothelium, and significantly attenuted in the older beagle arteries. In adult (2 year old) and aged beagle arteries, removal of the endothelium attenuated the histamineinduced relaxation. Treatment with indomethacin reversed the histamine-induced relaxation to a marked contraction in aged beagle arteries.3 It may be concluded that responses mediated by B-adrenoceptors and PI-purinoceptors are less in aged mesenteric arteries than in those from the younger beagles, whereas responses mediated by PGI2 receptors and the electrogenic Na+ pump do not alter with age. The release of endothelium-derived relaxing factor(s) by acetylcholine appears to be inversely related to age. However, the release of PGI2 possibly caused by histamine may be less in infant beagle mesenteric arteries than in those from the older beagles.

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Loss of H2 Histamine Receptor Activity in Rabbit Aorta after Maturity

Cited by 10 publications

References 0 publications

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Maternal and Fetal Platelet Responses and Adrenoceptor Binding Characteristics

Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle

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