Abstract:Background: The study of glomerular endothelial cell (GEnC) fenestrations including key regulatory factors is neglected despite their loss in diabetic nephropathy, a disease associated with decreased filtration function, being previously described.
Methods: We comprehensively characterised GEnC fenestral and renal filtration functional changes including measurement of glomerular ultrafiltration coefficient and glomerular filtration rate (GFR) in diabetic mice and humans. We further evaluated Eps homology dom… Show more
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