Loss of entorhinal cortex and hippocampal volumes compared to whole brain volume in normal aging: The SMART-Medea study

Knoops, Arnoud J.G.; Gerritsen, Lotte; Graaf, Yolanda van der; Mali, Willem P.Th.M.; Geerlings, Mirjam I.

doi:10.1016/j.pscychresns.2011.12.002

Cited by 25 publications

(11 citation statements)

References 54 publications

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“…However, in this study no sex differences in these curves were calculated. In contrast, other crosssectional studies using linear regression to estimate associations of age with hippocampal volume found an acceleration of volume loss at a slightly later age of 72 years (Zhang et al 2010), or no acceleration point (Knoops et al 2012).…”

Section: Trajectories Of Other Temporal Lobe Volumes With Agementioning

confidence: 79%

Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank

Nobis

Manohar

Smith

et al. 2019

Preprint

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Measurement of hippocampal volume has proven useful to diagnose and track progression in several brain disorders, most notably in Alzheimer’s disease (AD). For example, an objective evaluation of a patient’s hippocampal volume status may provide important information that can assist diagnosis or risk stratification of AD. However, clinicians and researchers require access to age-related normative percentiles to reliably categorise a patient’s hippocampal volume as being pathologically small. Here we analysed effects of age, sex, and hemisphere on the hippocampus and neighbouring temporal lobe volumes, in 19,793 generally healthy participants in the UK Biobank. A key finding of the current study is a significant acceleration in the rate of hippocampal volume loss in middle age, more pronounced in females than in males. In this report, we provide normative values for hippocampal and total grey matter volume as a function of age for reference in clinical and research settings. These normative values may be used in combination with our online, automated percentile estimation tool to provide a rapid, objective evaluation of an individual’s hippocampal volume status. The data provide a large-scale normative database to facilitate easy age-adjusted determination of where an individual hippocampal and temporal lobe volume lies within the normal distribution.

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Section: Trajectories Of Other Temporal Lobe Volumes With Agementioning

confidence: 79%

Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank

Nobis

Manohar

Smith

et al. 2019

Preprint

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“…The total number of hippocampi was 40 per tracer (2 subjects × 5 score of MTA scale × 2 field strength × 2 sides). The naïve tracers' and local protocols were (initials of the tracers, either listed among authors or in the acknowledgments, and reference in brackets): AC [16], CBa [17], CBo [18], EB [19,20], EC [21], FvD [22], KF [23], MB [24], MG [21], SH [unpublished], ML [21], YL [25], OM [unpublished], MN [21], MPo [26], GP [27], MPr [22], TSt [28], TSw [29], MT [30], CW [27]. …”

Section: Methodsmentioning

confidence: 99%

“…Resampling was carried out with a linear transformation with a linear interpolation scheme in AutoReg. However, the tracers were allowed to reorient images according to local protocols if these required a specific orientation (as was the case for CBa [17], FvD [22], KF [23], MB [24], SH [unpublished], YL [25], OM [unpublished], MPo [26], GP [27], MPr [22], TSt [28], MT [30], CW [29]). In these cases, tracers were recommended to use of a six DoF function without normalization or other preprocessing.…”

Section: Methodsmentioning

confidence: 99%

The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Frisoni¹,

Jack²,

Bocchetta³

et al. 2014

Alzheimer's & Dementia

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170

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Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001). Conclusions The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.

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“…Several investigations (see, for example, References [55][56][57]) showed lager hippocampal volumes in females as compared with males. In addition, Lehman and colleagues [58] demonstrated that aged females seemed to be less affected by the deleterious effects of APOE4 on brain structure and cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in the Complexity of Healthy Older Adults’ Magnetoencephalograms

Shumbayawonda

Abásolo

López‐Sanz

et al. 2019

Entropy

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The analysis of resting-state brain activity recording in magnetoencephalograms (MEGs) with new algorithms of symbolic dynamics analysis could help obtain a deeper insight into the functioning of the brain and identify potential differences between males and females. Permutation Lempel-Ziv complexity (PLZC), a recently introduced non-linear signal processing algorithm based on symbolic dynamics, was used to evaluate the complexity of MEG signals in source space. PLZC was estimated in a broad band of frequencies (2–45 Hz), as well as in narrow bands (i.e., theta (4–8 Hz), alpha (8–12 Hz), low beta (12–20 Hz), high beta (20–30 Hz), and gamma (30–45 Hz)) in a sample of 98 healthy elderly subjects (49 males, 49 female) aged 65–80 (average age of 72.71 ± 4.22 for males and 72.67 ± 4.21 for females). PLZC was significantly higher for females than males in the high beta band at posterior brain regions including the precuneus, and the parietal and occipital cortices. Further statistical analyses showed that higher complexity values over highly overlapping regions than the ones mentioned above were associated with larger hippocampal volumes only in females. These results suggest that sex differences in healthy aging can be identified from the analysis of magnetoencephalograms with novel signal processing methods.

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Loss of entorhinal cortex and hippocampal volumes compared to whole brain volume in normal aging: The SMART-Medea study

Cited by 25 publications

References 54 publications

Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank

Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank

The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Sex Differences in the Complexity of Healthy Older Adults’ Magnetoencephalograms

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