Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas

Chen, Hui‐Chun; Chu, Ricky Yuan-Yuan; Hsu, Ping-Ning; Hsu, Ping I.; Lu, Jau-Yeong; Lai, Kwok-Hung; Tseng, Hui‐Hwa; Chou, Nan‐Hua; Huang, Ming-Shyan; Tseng, Ching‐Jiunn; Hsiao, Michael

doi:10.1016/j.canlet.2003.07.007

Cited by 98 publications

(84 citation statements)

References 23 publications

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“…No statistically significant correlation was also observed between E-cadherin expression and patients' gender or histological differentiation grade. This is consistent with the results reported by Chen et al [22], who found no correlation between E-cadherin and can- cer stage, vascular invasion, lymph node involvement or the presence of distant metastases. However, loss of E-cadherin expression was much more frequent in carcinomas that metastasize to distant organs than in those which do not [22].…”

Section: Discussionsupporting

confidence: 93%

“…This is consistent with the results reported by Chen et al [22], who found no correlation between E-cadherin and can- cer stage, vascular invasion, lymph node involvement or the presence of distant metastases. However, loss of E-cadherin expression was much more frequent in carcinomas that metastasize to distant organs than in those which do not [22]. On the other hand, Scartozzi et al [23] observed "abnormal" E-cadherin expression more frequently in diffuse-type gastric cancer than in intestinal type according to Lauren's classification.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.

Czyżewska

Guzińska‐Ustymowicz²,

Ustymowicz³

et al. 2010

Folia Histochem Cytobiol.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.

Czyżewska

Guzińska‐Ustymowicz²,

Ustymowicz³

et al. 2010

Folia Histochem Cytobiol.

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“…E-cadherin loss has also been reported in primary gastric ImPC and one of the reported case also had a 23.5 % Ki-67 expression rate as a predictive marker of poor prognosis (12,13). In our case, loss of E-cadherin expression was observed in both ImPC and poorly differentiated component of the tumor similar to reported by Shimoda et al (8).…”

Section: Discussionsupporting

confidence: 88%

Primary gastric invasive micropapillary carcinoma: a case report

Vardar

Yardim²,

Vardar³

et al. 2013

TJPATH

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Invasive micropapillary carcinoma is a recently identified neoplasm. A 77-year-old-female was admitted to the hospital due to progressive loss of weight and nausea. Endoscopic biopsy of the antral/prepyloric located mass was diagnosed as moderately differentiated adenocarcinoma. Subtotal gastrectomy and regional lymph node resection were performed. The tumor was composed of moderately differentiated cells arranged in micropapillary structures with only a few poorly formed glandular foci in lamina propria. Immunohistochemically, neoplastic cells of micropapillary and focal conventional adenocarcinoma areas were diffusely positive for pancytokeratin, cytokeratin 7 and epithelial membrane antigen. In micropapillary areas, membranous and peripheral cytoplasmic positivity with epithelial membrane antigen in outside of the cell clusters called "inside-out polarity" pattern that is characteristic for invasive micropapillary carcinoma were seen. Invasive micropapillary carcinoma is very rare in the stomach in the English literature. Key Words: Stomach neoplasms, Gastrointestinal neoplasms, Papillary carcinoma ÖZİnvaziv mikropapiller karsinom yeni tanımlanan bir tümördür. Progressif kilo kaybı ve bulantı nedeniyle hastaneye yatırılan 77 yaşındaki kadın hastanın endoskopik biyopsisinde antral/prepilorik yerleşimli, orta derecede diferansiye adenokarsinom saptandı. Sonrasında subtotal gastrektomi ve lenf düğümü rezeksiyonu yapıldı. Tümör, orta derecede diferansiye hücrelerin oluşturduğu mikropapiller ve az sayıda glandüler yapılardan oluşmaktaydı. İmmunohistokimyasal olarak mikropapiller ve glandüler alanlarda pansitokeratin, sitokeratin 7 ve epitelyal membran antijen pozitifti. mikropapiller alanlarda, hücre kümelerinin çevresinde periferal lokalizasyonda epitelyal membran antijen ile invazive mikropapiller karsinom için karakteristik membranöz, sitoplazmik pozitiflik saptandı. Literatürde mide yerleşimli invazive mikropapiller karsinom oldukça nadirdir.

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“…(19,20) Each type reveals different characteristics with regard to clinicopathological parameters and genetic differences, and candidate genes responsible for those phenotypic differences have been proposed. (2,(21)(22)(23)(24) The ability of CGH-arrays to differentiate among histological types of renal cancer (25) suggested that we might be able to identify novel genes involved in different histological types of GC by CGH-array analysis. According to the degree of differentiation, we classified 28 of our GC cell lines into well-differentiated and undifferentiated types, on the basis of the diagnoses of the primary tumors from which they were derived, and compared their patterns of copy-number aberrations.…”

Section: Resultsmentioning

confidence: 99%

Screening of DNA copy‐number aberrations in gastric cancer cell lines by array‐based comparative genomic hybridization

et al. 2005

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We performed genome-wide screening for deoxyribonucleic acid copy-number aberrations in 31 gastric cancer (GC) cell lines by using custom-made comparative genomic hybridization (CGH)-array. Copy-number gains were frequently detected at 1q, 3q, 5p, 7p, 7q, 8q, 11q, 17q, 20p, 20q, Xp and Xq, and losses at 3p, 4p, 4q, 8p, 9p, 18p and 18q. With respect to histological subtypes, copy-number gains at 1p, 16p, 20p, 20q and 22q, and losses at 8p, 10p, 10q and 18q were significantly frequent in cell lines derived from tumors of the well-differentiated type, whereas copy-number gains at 1q, 7p, 7q, Xp and Xq were frequent in the undifferentiated type. Homozygous deletions were seen at five loci, whereas high-level amplifications were detected in 15 of the 31 GC cell lines; these had occurred at 24 loci, including the segment containing CDK6 (7q21.2). Amplification of that gene had never been reported in GC before. Immunohistochemical studies showed increased levels of CDK6 protein in 54 of the 292 primary GC samples we examined (18.5%). Cytoplasmic localization of CDK6, as well as CDK6 over-expression, was more frequent in well-differentiated GC than in undifferentiated tumors. Nuclear expression of CDK6 was more frequent in early stage GC than in advanced tumors, suggesting that nuclear localization of CDK6 is likely to be a prognostic factor for GC. Taken together, our data indicate that CDK6 might be involved in the pathogenesis of GC and, more generally, that CGH-arrays have a powerful potential for identifying novel cancer-related genetic changes in a variety of tumors. (Cancer Sci 2005; 96: 100-110)

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Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas

Cited by 98 publications

References 23 publications

The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.

The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.

Primary gastric invasive micropapillary carcinoma: a case report

Screening of DNA copy‐number aberrations in gastric cancer cell lines by array‐based comparative genomic hybridization

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