Loss of Calcium Homeostasis Leads to Progressive Phase of Chlordecone-Potentiated Carbon Tetrachloride Hepatotoxicity

Kodavanti, Prasada Rao S.; Rao, Vaman C.; Mehendale, Harihara M.

doi:10.1006/taap.1993.1174

Cited by 9 publications

(3 citation statements)

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“…The tissue specific trends obtained were in agreement with the sequence as cited by Stuehr (1992). The studies of Vincent and Kimura (1992) Guzelian (1982); Bansal and Desaiah (1982a), Kodavanti et al, (1993); Mehendale (1995); showed inhibition of ATPase activity by various doses of chlordecone. Since ATPase is one of the CaM-dependent enzymes, from the reports of the above authors it may be stated that chlordecone interacts with CaM-mediated events.…”

Section: Discussionsupporting

confidence: 84%

Untitled

2014

IOSRJPBS

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In view of the neurotoxic effects induced by chlordecone an attempt is made to study the in vivo effect of this organic insecticide on rat brain based nitric oxide synthase (NOS) activity. Rats cerebellum, hypothalamus, midbrain, straiatum, hippocampus, cerebral cortex and medulla oblongate receiving sub-lethal and lethal doses of chlordecone showed decreased levels of their constitutive NOS activity and the changes were found to be statistically significant (p<0.001) over the control. Since cNOS activity in dependent on calcium / calmodulin, interaction of chlordecone with Ca²⁺/ CaM mediated events might be the reason for inhibition of cNOS activity of various brain parts of rats.

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Section: Discussionsupporting

confidence: 84%

Untitled

2014

IOSRJPBS

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“…Interaction with cell membranes partly explains the action of CLD, which is known to alter cellular functions of the central nervous system. In addition, low CLD concentrations interact with hormone receptors (estrogenic receptors and other endocrine receptors) and induce a hormone-like effect that explains CLD toxicity on animal reproduction (Fujimori et al 1982;Squibb and Tilson 1982;Linder et al 1983;Desaiah 1985;Swartz et al 1988;Kodavanti et al 1990Kodavanti et al , 1993Vaccari and Saba 1995). These studies were mainly carried out on animals.…”

Section: Introductionmentioning

confidence: 97%

Evaluation of the ecotoxicological impact of the organochlorine chlordecone on soil microbial community structure, abundance, and function

Merlin

Devers

Beguet

et al. 2015

Environ Sci Pollut Res

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The insecticide chlordecone applied for decades in banana plantations currently contaminates 20,000 ha of arable land in the French West Indies. Although the impact of various pesticides on soil microorganisms has been studied, chlordecone toxicity to the soil microbial community has never been assessed. We investigated in two different soils (sandy loam and silty loam) exposed to different concentrations of CLD (D0, control; D1 and D10, 1 and 10 times the agronomical dose) over different periods of time (3, 7, and 32 days): (i)

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“…The reports of Desaiah and Koch (1975 Kodavanti et al, (1993); Mehendale (1995); showed inhibition of ATPase activity by various doses of chlordecone. Since ATPase is one of the CaM-dependent enzymes, from the reports of the above authors it may be stated that chlordecone interacts with CaM-mediated events.…”

Section: Discussionmentioning

confidence: 96%