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citations
Cited by 6 publications
(6 citation statements)
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References 7 publications
(12 reference statements)
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“…In this regard, the recovery of p53 in AgRP neurons of AgRPp53 KO mice fed a HFD, reversed their obese phenotype, and stimulated BAT thermogenesis. Moreover, our results are also in agreement with an in vitro study demonstrating that loss of p53 function activates the IRE1α/XBP1 pathway to enhance protein folding, suggesting that defects in the p53 complex represents a new mechanism for ER function modulation 59 , 60 . Furthermore, we found that obese AgRPp53 KO mice centrally treated with TUDCA showed a reduction in food intake, body weight, and adiposity.…”
Section: Discussionsupporting
confidence: 91%
“…Activation of p53 has been revealed to suppress the activity of the mechanistic target of rapamycin and inhibit the translation of certain proteins (26). The elimination of p53 may provide an opportunity for cancer cells to promote unregulated proliferation due to increased protein synthesis and a subsequent increase in ER function (9). In the current study, the expression of p53 affected the extent of TSA-induced ER stress.…”
Section: Discussionmentioning
confidence: 63%
“…The ER stress response activates cytotoxic mechanisms involving a number of regulatory cytokines associated with the onset of programmed cell death, suggesting this is a possible target in the development of chemotherapeutic agents for inducing cancer cell toxicity (8). As an essential tumor suppressor, the TP53 gene regulates the processes of ER stress, apoptosis, DNA repair, cell cycle and nuclear vesicular trafficking, in the presence of cellular stressors, including hypoxia, DNA damage and oncogene activation (9,10). Previous studies have revealed that p53 is upregulated in response to ER stress and participates in ER stress-induced apoptosis (11).…”
Section: Introductionmentioning
confidence: 99%
“…p21 inhibits cyclin-dependent kinase and arrests the cell cycle from G1 to S [ 44 ]. p53 also regulates the expression of ER-related genes, such as Gadd45-α, p48-XPE, and DNA polymerase [ 45 ]. Gadd45-α binds to UVB-induced DNA damage lesions and recruits DNA repair proteins [ 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, this endothelium defender (P53) [14] has been shown to be a direct target of the unfolded protein response (UPR) [21,22]. UPR acts to restore impaired functions of damaged tissues [23], including the lungs [24,25] and affects P53 levels in a positive manner.…”
mentioning
confidence: 99%