2017
DOI: 10.18632/aging.101184
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Abstract: Persons living with human immunodeficiency virus (HIV) harbor an increased risk of age-related conditions. We measured changes in telomere length and DNA methylation in the peripheral blood of 31 intravenous drug users, who were followed longitudinally with blood samples pre-HIV (T1), immediately post-HIV (T2; 1.9±1 year from T1), and at a later follow-up time (T3; 2.2±1 year from T2). Absolute telomere length measurements were performed using polymerase chain reaction methods. Methylation profiles were obtain… Show more

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Cited by 27 publications
(26 citation statements)
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References 52 publications
(61 reference statements)
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“…13 Telomere shortening during HIV seroconversion has also been reported in a smaller sample (n = 31), using a different telomere length assay and an extended time gap (2 years) between preseroconversion and postseroconversion sampling. 16 Our study confirms this and demonstrates that rapid telomere shortening occurs quickly after HIV seroconversion, and faster than after HCV seroconversion.…”
Section: Discussionsupporting
confidence: 88%
“…13 Telomere shortening during HIV seroconversion has also been reported in a smaller sample (n = 31), using a different telomere length assay and an extended time gap (2 years) between preseroconversion and postseroconversion sampling. 16 Our study confirms this and demonstrates that rapid telomere shortening occurs quickly after HIV seroconversion, and faster than after HCV seroconversion.…”
Section: Discussionsupporting
confidence: 88%
“…Although telomere shortening has been shown in acute infections in experimental animal models (Asghar, Hasselquist, et al., 2015; Asghar et al., 2016; Ilmonen et al., 2008), such effect has not been reported in humans. Previous studies have shown that chronic viral infections (i.e., HCV, CMV, and HIV) accelerate cellular aging in humans, as reflected by shorter telomere length and elevated CDKN2A expression (van de Berg et al., 2010; Gianesin et al., 2016; Leung et al., 2017; Pathai et al., 2013; Robinson et al., 2013; Zannetti et al., 2006). Furthermore, genome‐wide association studies (GWAS) have linked CDKN2A to many age‐related pathologies, including susceptibility to frailty and increased risk of coronary artery disease, myocardial infarction, type 2 diabetes, and Alzheimer's disease (Jeck et al., 2012).…”
Section: Discussionmentioning
confidence: 99%
“…In this study of acute malaria infection, we find distinct dynamics of cellular aging not observed during chronic infection (van de Berg et al., 2010; Gianesin et al., 2016; Leung et al., 2017; Pathai et al., 2013; Robinson et al., 2013; Zannetti et al., 2006). After successful treatment and in the absence of new infections, the effect on cellular aging markers was largely reversed as reflected by lower CDKN2A expression, higher telomerase activity, and gradual restoration of telomere length in peripheral blood of travelers from three months postinfection up to one year.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, no changes in rates of telomere shortening were found when HIV-infected individuals were switched from an ART regimen of darunavir/ritonavir supplemented with nonnucleoside reverse transcriptase inhibitor (NNRTI) to darunavir/ritonavir without NNRTI (Solomon et al 2014 ). Telomere shortening occurred after seroconversion, but no further shortening was observed with prolonged infection (Leung et al 2017 ), possibly suggesting accentuated aging as measured by telomere length.…”
Section: Molecular Markers Associated With Hiv and Agingmentioning
confidence: 99%