2015
DOI: 10.1371/journal.pone.0145454
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Abstract: Despite the increasing numbers of studies investigating hepatitis A diagnostic through saliva, the frequency and the pattern of hepatitis A virus (HAV) markers in this fluid still remains unknown. To address this issue, we carried on a longitudinal study to examine the kinetics of HAV markers in saliva, in comparison with serum samples. The present study followed-up ten patients with acute hepatitis A infection during 180 days post diagnosis (dpd). Total anti-HAV was detected in paired serum and saliva samples… Show more

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Cited by 12 publications
(5 citation statements)
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“…Numerous viruses including hepatitis A, B, and C viruses, 5457 cytomegalovirus, 58,59 Epstein Barr virus, 60 virus herpes (1,2,6,7,8) 61 and recently Zika virus 62 can be isolated from the saliva. Moreover, measuring the level of salivary antibodies enables detection of Morbillivirus infection causing measles (with 97% sensitivity and 100% specificity), 63 Paramyxoviridae causing mumps (94% sensitivity and 94% specificity), or Togaviridiae causing rubella (98% sensitivity and 98% specificity).…”
Section: Areas Of Diagnostic Application Of Salivamentioning
confidence: 99%
“…Numerous viruses including hepatitis A, B, and C viruses, 5457 cytomegalovirus, 58,59 Epstein Barr virus, 60 virus herpes (1,2,6,7,8) 61 and recently Zika virus 62 can be isolated from the saliva. Moreover, measuring the level of salivary antibodies enables detection of Morbillivirus infection causing measles (with 97% sensitivity and 100% specificity), 63 Paramyxoviridae causing mumps (94% sensitivity and 94% specificity), or Togaviridiae causing rubella (98% sensitivity and 98% specificity).…”
Section: Areas Of Diagnostic Application Of Salivamentioning
confidence: 99%
“…There are two important aspects that should be considered to collect saliva: the type (total or gland-specific) and the level of stimulation (stimulated or unstimulated) [49]. Total saliva originates mainly from salivary glands, the parotid, sublingual, and submandibular, and also contains gingival crevicular fluid (GCF); it is a plasma transudate, which constantly flows from the crevice between the gum margin and the teeth [50]; its collection is simple and does not require much equipment. Oral fluid contains principally GCF that is an ultrafiltrate of plasma that enters the oral cavity by transudation from capillaries present in the mucosa of the gingival space [13]; its collection coming from a specific gland and is a little more difficult [51, 52].…”
Section: Oral Fluid Samples For Infectious Disease Diagnosismentioning
confidence: 99%
“…These characteristics make the collection of this fluid very attractive in children, the elderly and other individuals with difficult venous access [52]. On the other hand, some difficulties are observed when working with saliva due to their low IgG concentration compared to those observed in serum samples [50, 53] and the presence of enzymes with DNAs and RNAs activity that can degrade the DNA molecules, as well as inhibit their PCR amplification [48].…”
Section: Oral Fluid Samples For Infectious Disease Diagnosismentioning
confidence: 99%
“…Oral fluid contains saliva from the salivary glands and gingival crevicular fluid, which is a transudate plasma derived from the capillary bed beneath the tooth–gum margin [10, 11]. The primary drawback of this sample source however, is that the concentration of IgG in oral fluid has been reported to be substantially lower (average 300 times) when compared to its concentration in serum [12–15].…”
Section: Introductionmentioning
confidence: 99%
“…The use of oral fluid samples as a noninvasive alternative to blood for the detection of virus-specific antibodies was first promoted by Parry et al [16]. Since then these samples have been used to detect Varicella, Herpes simplex, human immunodeficiency virus (HIV), Hepatitis A virus (HAV) and Hepatitis C virus (HCV) markers [11, 1521]. HBV markers have previously been detected in oral fluid samples, especially the surface antigen of the hepatitis B virus (HBsAg) [5, 7, 2229].…”
Section: Introductionmentioning
confidence: 99%