Longitudinal fixel-based analysis reveals restoration of white matter alterations following balance training in young brain-injured patients

Liang, Xiaoyun; Yeh, Chun‐Hung; Domínguez, F D Juan; Poudel, Govinda; Swinnen, Stephan P.; Caeyenberghs, Karen

doi:10.1016/j.nicl.2021.102621

Cited by 14 publications

(20 citation statements)

References 65 publications

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“…It is likely that reduced FD negatively impacts the efficiency of signal transmission necessary for sustaining attention during a task, leading to a greater susceptibility to attentional lapses. Further, the absence of an association with FC and FDC further underlines that interindividual variability in attentional lapses is specific to decreased total intra‐axonal volume or an increase in strength of the connections (i.e., density of streamlines) across those significant areas (Dhollander et al, 2020; Dimond et al., 2019; Genc et al., 2017; Liang et al., 2021). However, it is important to note that the exact physiological mechanisms underlying FBA metrics are still unclear.…”

Section: Discussionmentioning

confidence: 99%

Individual differences in attentional lapses are associated with fiber‐specific white matter microstructure in healthy adults

Clemente

Imms

et al. 2021

Psychophysiology

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Attentional lapses interfere with goal-directed behaviors, which may result in harmless (e.g., not hearing instructions) or severe (e.g., fatal car accident) consequences.Task-related functional MRI (fMRI) studies have shown a link between attentional lapses and activity in the frontoparietal network. Activity in this network is likely to be mediated by the organization of the white matter fiber pathways that connect the regions implicated in the network, such as the superior longitudinal fasciculus I (SLF-I). In the present study, we investigate the relationship between susceptibility to attentional lapses and relevant white matter pathways in 36 healthy adults ( 23females, M age = 31.56 years). Participants underwent a diffusion MRI (dMRI) scan and completed the global-local task to measure attentional lapses, similar to previous fMRI studies. Applying the fixel-based analysis framework for fiberspecific analysis of dMRI data, we investigated the association between attentional lapses and variability in microstructural fiber density (FD) and macrostructural (morphological) fiber-bundle cross section (FC) in the SLF-I. Our results revealed a significant negative association between higher total number of attentional lapses and lower FD in the left SLF-I. This finding indicates that the variation in the microstructure of a key frontoparietal white matter tract is associated with attentional lapses and may provide a trait-like biomarker in the general population. However, SLF-I microstructure alone does not explain propensity for attentional lapses, as other factors such as sleep deprivation or underlying psychological conditions (e.g., sleep disorders) may also lead to higher susceptibility in both healthy people and those with neurological disorders. K E Y W O R D S attentional lapses, diffusion MRI, fixel-based analysis, global-local task, superior longitudinal fasciculus I 2 of 16 | CLEMENTE ET aL. F I G U R E 1 (a) Global-local task stimuli for the congruent, incongruent, and neutral condition and (b) example instructions and target stimuli of the global and local trials for each of the three conditions

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Section: Discussionmentioning

confidence: 99%

Individual differences in attentional lapses are associated with fiber‐specific white matter microstructure in healthy adults

Clemente

Imms

et al. 2021

Psychophysiology

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“…Overall, with further extensions (e.g., incorporating behavioural data) and validations in future studies, our profiles may assist clinicians in implementing personalised training programs in m-sTBI patients. For example, TBI4 with the damaged voxels in sensorimotor tracts can benefit from a motor training program (such as a balance training program) to improve motor functioning and restore white matter organisation (Liang et al, 2021).…”

Section: State-of-the Art Processing Pipeline and Implications Of Sin...mentioning

confidence: 99%

“…We have chosen FBA over the traditional diffusion tensor approach (as was done in the study of Jolly et al 2020), as FBA offers greater specificity (Dhollander et al 2021;Raffelt et al, 2012;Liang et al, 2021;Mito et al, 2018).…”

Section: Individualised Profiling Of White Matter Organisation In Mod...mentioning

confidence: 99%

“…To this end, we will utilise the TractLearn framework (Attye et al, 2021) to determine whether the fibre density (FD) values (derived from fixel-based analysis (FBA; Raffelt et al, 2015; Raffelt et al, 2017) of white matter tracts of an individual patient deviate from a healthy reference group (N=12). We have chosen FBA over the traditional diffusion tensor approach (as was done in the study of Jolly et al 2020), as FBA offers greater specificity (Dhollander et al 2021; Raffelt et al, 2012; Liang et al, 2021; Mito et al, 2018).…”

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confidence: 99%

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Individualised Profiling of White Matter Organisation in Moderate-to-Severe Traumatic Brain Injury Patients Using TractLearn: A Proof-of-Concept Study

Clemente

Attyé

Renard

et al. 2022

Preprint

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Approximately 65% of moderate-to-severe traumatic brain injury (m-sTBI) patients present with poor long-term behavioural outcomes, which can significantly impair activities of daily living. Numerous diffusion-weighted MRI studies have linked these poor outcomes to decreased white matter integrity of several commissural tracts, association fibres and projection fibres in the brain. However, these studies focused on group-based analyses, which are unable to deal with the substantial between-patient heterogeneity in m-sTBI. As a result, there is increasing interest in conducting individualised neuroimaging analyses. Here, we generated a detailed subject-specific characterisation of microstructural organisation of white matter tracts in 5 chronic patients with m-sTBI (29 – 49y, 2 females). We developed an imaging analysis framework using fixel-based analysis and TractLearn to determine whether the values of fibre density of white matter tracts at the individual patient level deviate from the healthy control group (n = 12, 8F, Mage=35.7y, age range 25 – 64y). Our individualised analysis confirmed unique white matter profiles, and the heterogeneous nature of m-sTBI to properly characterise the extent of brain abnormality. Future studies incorporating clinical data, as well as utilising larger reference samples and examining the test-retest reliability of the fixel-wise metrics are warranted. This proof-of-concept study suggests that these resulting individual profiles may assist clinicians in planning personalised training programs for chronic m-sTBI patients, which is necessary to achieve optimal behavioural outcomes and improved quality of life.

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“…The neurological sequelae of moderate or severe TBI include sensorimotor and cognitive deficits. While sensorimotor functions after TBI can be improved at least in part through rehabilitation training, 1 cognitive impairments are long-lasting and adversely impact quality of life of TBI survivors. 2 Currently, there is no approved therapy to prevent post-TBI cognitive dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury

Zhao

et al. 2021

J Cereb Blood Flow Metab

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Traumatic brain injury (TBI) is commonly followed by long-term cognitive deficits that severely impact the quality of life in survivors. Recent studies suggest that microglial/macrophage (Mi/MΦ) polarization could have multidimensional impacts on post-TBI neurological outcomes. Here, we report that repetitive intranasal delivery of interleukin-4 (IL-4) nanoparticles for 4 weeks after controlled cortical impact improved hippocampus-dependent spatial and non-spatial cognitive functions in adult C57BL6 mice, as assessed by a battery of neurobehavioral tests for up to 5 weeks after TBI. IL-4-elicited enhancement of cognitive functions was associated with improvements in the integrity of the hippocampus at the functional ( e.g., long-term potentiation) and structural levels (CA3 neuronal loss, diffusion tensor imaging of white matter tracts, etc.). Mechanistically, IL-4 increased the expression of PPARγ and arginase-1 within Mi/MΦ, thereby driving microglia toward a global inflammation-resolving phenotype. Notably, IL-4 failed to shift microglial phenotype after TBI in Mi/MΦ-specific PPARγ knockout (mKO) mice, indicating an obligatory role for PPARγ in IL-4-induced Mi/MΦ polarization. Accordingly, post-TBI treatment with IL-4 failed to improve hippocampal integrity or cognitive functions in PPARγ mKO mice. These results demonstrate that administration of exogenous IL-4 nanoparticles stimulates PPARγ-dependent beneficial Mi/MΦ responses, and improves hippocampal function after TBI.

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Longitudinal fixel-based analysis reveals restoration of white matter alterations following balance training in young brain-injured patients

Cited by 14 publications

References 65 publications

Individual differences in attentional lapses are associated with fiber‐specific white matter microstructure in healthy adults

Individual differences in attentional lapses are associated with fiber‐specific white matter microstructure in healthy adults

Individualised Profiling of White Matter Organisation in Moderate-to-Severe Traumatic Brain Injury Patients Using TractLearn: A Proof-of-Concept Study

Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury

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