Longitudinal Cortical Atrophy in Amyotrophic Lateral Sclerosis With Frontotemporal Dementia

Cortical Thickness in Frontotemporal Dementia, Mild Cognitive Impairment, and Alzheimer's Disease

“…The insular region has been shown to be atrophic in FTD also by other MRI methods (VBM) [73,79,80]. Moreover, the lateral temporal cortices and medial temporal lobes were thinner in FTD patients in this study compared to healthy controls, which is also in line with a few recent FTD-related CTH studies, although in these studies the FTD groups were composed of different types of FTD subjects [22,26,27,81] including a group of four FTD/ALS patients [82], whereas our patients mostly represented bvFTD including two FTD/ALS cases. Further, regarding the FTD types, some studies that only included semantic patients [30] or pathologically confirmed heterogeneous FTD cases [28] showed the most prominent findings in the left temporal lobe, including the entrorhinal cortex, hippocampus, parahippocampus, amygdala, and medial inferior temporal gyrus.…”

Cortical Thickness in Frontotemporal Dementia, Mild Cognitive Impairment, and Alzheimer's Disease

“…The insular region has been shown to be atrophic in FTD also by other MRI methods (VBM) [73,79,80]. Moreover, the lateral temporal cortices and medial temporal lobes were thinner in FTD patients in this study compared to healthy controls, which is also in line with a few recent FTD-related CTH studies, although in these studies the FTD groups were composed of different types of FTD subjects [22,26,27,81] including a group of four FTD/ALS patients [82], whereas our patients mostly represented bvFTD including two FTD/ALS cases. Further, regarding the FTD types, some studies that only included semantic patients [30] or pathologically confirmed heterogeneous FTD cases [28] showed the most prominent findings in the left temporal lobe, including the entrorhinal cortex, hippocampus, parahippocampus, amygdala, and medial inferior temporal gyrus.…”

Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders

“…Bulbar deficits in ALS have been related to motor cortex, 45 and in patients with ALS with bulbar disease, atrophy has been localized to the homuncular representation of the larynx. [46][47][48][49][50] Consistent with these findings, our direct assessment of a relationship between f0 range and cortical thickness supports the association of this acoustic measure with bulbar disease mediated in part by atrophy in precentral gyri. The association with the planum temporale may be related in part to a feedback mechanism to monitor the acoustic properties of one's own speech and may be helpful in clarifying articulatory production.…”

Distinct disease trajectories in frontotemporal dementia–motor neuron disease and behavioural variant frontotemporal dementia: A longitudinal study

“…respectively [34][35][36], showed progression of atrophy in FTDas disease progressed. Our results are broadly consistent with previous findings that reported progressive involvement of the bilateral premotor cortex, primary motor cortex, and parietal lobe (i.e., Brodmann areas 4, 6, and 7) over a mean time period of 5.3 months [37]. The present study confirmed these results, albeit with a larger cohort of patients and a longer period of follow-up (mean = 10.4 months).…”

Cortical Thickness in Frontotemporal Dementia, Mild Cognitive Impairment, and Alzheimer's Disease

“…The insular region has been shown to be atrophic in FTD also by other MRI methods (VBM) [73,79,80]. Moreover, the lateral temporal cortices and medial temporal lobes were thinner in FTD patients in this study compared to healthy controls, which is also in line with a few recent FTD-related CTH studies, although in these studies the FTD groups were composed of different types of FTD subjects [22,26,27,81] including a group of four FTD/ALS patients [82], whereas our patients mostly represented bvFTD including two FTD/ALS cases. Further, regarding the FTD types, some studies that only included semantic patients [30] or pathologically confirmed heterogeneous FTD cases [28] showed the most prominent findings in the left temporal lobe, including the entrorhinal cortex, hippocampus, parahippocampus, amygdala, and medial inferior temporal gyrus.…”

Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders

“…Bulbar deficits in ALS have been related to motor cortex, 45 and in patients with ALS with bulbar disease, atrophy has been localized to the homuncular representation of the larynx. [46][47][48][49][50] Consistent with these findings, our direct assessment of a relationship between f0 range and cortical thickness supports the association of this acoustic measure with bulbar disease mediated in part by atrophy in precentral gyri. The association with the planum temporale may be related in part to a feedback mechanism to monitor the acoustic properties of one's own speech and may be helpful in clarifying articulatory production.…”

Distinct disease trajectories in frontotemporal dementia–motor neuron disease and behavioural variant frontotemporal dementia: A longitudinal study

“…respectively [34][35][36], showed progression of atrophy in FTDas disease progressed. Our results are broadly consistent with previous findings that reported progressive involvement of the bilateral premotor cortex, primary motor cortex, and parietal lobe (i.e., Brodmann areas 4, 6, and 7) over a mean time period of 5.3 months [37]. The present study confirmed these results, albeit with a larger cohort of patients and a longer period of follow-up (mean = 10.4 months).…”

Cortical Thickness in Frontotemporal Dementia, Mild Cognitive Impairment, and Alzheimer's Disease

“…The insular region has been shown to be atrophic in FTD also by other MRI methods (VBM) [73,79,80]. Moreover, the lateral temporal cortices and medial temporal lobes were thinner in FTD patients in this study compared to healthy controls, which is also in line with a few recent FTD-related CTH studies, although in these studies the FTD groups were composed of different types of FTD subjects [22,26,27,81] including a group of four FTD/ALS patients [82], whereas our patients mostly represented bvFTD including two FTD/ALS cases. Further, regarding the FTD types, some studies that only included semantic patients [30] or pathologically confirmed heterogeneous FTD cases [28] showed the most prominent findings in the left temporal lobe, including the entrorhinal cortex, hippocampus, parahippocampus, amygdala, and medial inferior temporal gyrus.…”

Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders

“…Bulbar deficits in ALS have been related to motor cortex, 45 and in patients with ALS with bulbar disease, atrophy has been localized to the homuncular representation of the larynx. [46][47][48][49][50] Consistent with these findings, our direct assessment of a relationship between f0 range and cortical thickness supports the association of this acoustic measure with bulbar disease mediated in part by atrophy in precentral gyri. The association with the planum temporale may be related in part to a feedback mechanism to monitor the acoustic properties of one's own speech and may be helpful in clarifying articulatory production.…”

Distinct disease trajectories in frontotemporal dementia–motor neuron disease and behavioural variant frontotemporal dementia: A longitudinal study

“…respectively [34][35][36], showed progression of atrophy in FTDas disease progressed. Our results are broadly consistent with previous findings that reported progressive involvement of the bilateral premotor cortex, primary motor cortex, and parietal lobe (i.e., Brodmann areas 4, 6, and 7) over a mean time period of 5.3 months [37]. The present study confirmed these results, albeit with a larger cohort of patients and a longer period of follow-up (mean = 10.4 months).…”