Longitudinal cognitive changes in traumatic brain injury

Himanen, Leena; Portin, Raija; Isoniemi, Heli; Helenius, Hans; Kurki, Timo; Tenovuo, Olli

doi:10.1212/01.wnl.0000194264.60150.d3

Cited by 197 publications

(167 citation statements)

References 36 publications

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“…Almost one third of the patients with mild TBI had normal findings on conventional 3T MR images of the brain (subjects 4,8,13,18,19,[21][22][23][24]27, and 32 in On-line Table 1), yet 10 of these 11 patients had at least 1 structure with FA values in the range defined as having microstructural injury.…”

Section: Resultsmentioning

confidence: 99%

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Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

Niogi¹,

Mukherjee²,

Ghajar³

et al. 2008

AJNR Am J Neuroradiol

532

392

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BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) may be a useful index of microstructural changes implicated in diffuse axonal injury (DAI) linked to persistent postconcussive symptoms, especially in mild traumatic brain injury (TBI), for which conventional MR imaging techniques may lack sensitivity. We hypothesized that for mild TBI, DTI measures of DAI would correlate with impairments in reaction time, whereas the number of focal lesions on conventional 3T MR imaging would not.

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Section: Resultsmentioning

confidence: 99%

“…20,21 More recent studies suggest that DAI causes persistent postconcussive symptoms in executive function and memory dysfunction. 8,[22][23][24][25] MR diffusion tensor imaging (DTI) may be used to better assess DAI. In DTI, the characteristics of water diffusion in the brain are used to assess microstructural integrity of white matter pathways.…”

mentioning

confidence: 99%

Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

Niogi¹,

Mukherjee²,

Ghajar³

et al. 2008

AJNR Am J Neuroradiol

532

392

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“…Given the youth of those injured, developing an understanding of factors predicting longer-term outcomes is important as a basis for planning for their future needs. Only a few studies have investigated factors predicting outcome more than 10 years after injury (Dawson & Chipman, 1995;Himanen et al, 2006;Hoofien et al, 2002;Johnson, 1998;Tate et al, 2005;Wood & Rutterford, 2006a). Findings from these long-term studies have been mixed, partly due to use of variable outcome measures.…”

Section: Introductionmentioning

confidence: 99%

Functional outcome 10 years after traumatic brain injury: Its relationship with demographic, injury severity, and cognitive and emotional status

Ponsford

Draper

Schönberger

2008

J. Inter. Neuropsych. Soc.

312

196

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Previous investigations of long-term outcome following traumatic brain injury (TBI) have yielded mixed results regarding the predictive power of injury severity and demographic factors. Furthermore, there has been limited investigation of the association between long-term outcome and current cognitive functioning and psychiatric state. The aim of this study was to investigate the association of injury severity, demographic factors, and concurrent cognitive and psychiatric functioning with functional outcome 10 years following mild to severe TBI. Outcome was rated using the Extended Glasgow Outcome Scale (GOSE) for 60 participants, who also completed neuropsychological measures of attention, speed of processing, memory and executive function and the Hospital Anxiety and Depression Scale (HADS). Outcome on the GOSE ranged from upper good recovery (32%) to lower severe disability (2%). Participants showing poorer outcome on the GOSE had significantly longer posttraumatic amnesia duration; less education; performed more poorly on cognitive measures of information processing speed, attention, memory, and executive function; and showed higher levels of anxiety on the HADS. (JINS, 2008, 14, 233-242.)

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“…7,8,[19][20][21][22][23] The most common complaints are in attention/concentration and working memory; that is, the ability to hold information in the mind, and to manipulate it in light of incoming material. 24 At 6 months post-injury, indices of executive function were found to predict persistence of post-concussive syndrome in mild and moderate TBI patients.…”

mentioning

confidence: 99%

Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study

Naeser

Zafonte²,

Krengel³

et al. 2014

Journal of Neurotrauma

229

204

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This pilot, open-protocol study examined whether scalp application of red and near-infrared (NIR) light-emitting diodes (LED) could improve cognition in patients with chronic, mild traumatic brain injury (mTBI). Application of red/NIR light improves mitochondrial function (especially in hypoxic/compromised cells) promoting increased adenosine triphosphate (ATP) important for cellular metabolism. Nitric oxide is released locally, increasing regional cerebral blood flow. LED therapy is noninvasive, painless, and non-thermal (cleared by the United States Food and Drug Administration [FDA], an insignificant risk device). Eleven chronic, mTBI participants (26-62 years of age, 6 males) with nonpenetrating brain injury and persistent cognitive dysfunction were treated for 18 outpatient sessions (Monday, Wednesday, Friday, for 6 weeks), starting at 10 months to 8 years post-mTBI (motor vehicle accident [MVA] or sports-related; and one participant, improvised explosive device [IED] blast injury). Four had a history of multiple concussions. Each LED cluster head (5.35 cm diameter, 500 mW, 22.2 mW/cm 2 ) was applied for 10 min to each of 11 scalp placements (13 J/cm 2 ). LEDs were placed on the midline from front-to-back hairline; and bilaterally on frontal, parietal, and temporal areas. Neuropsychological testing was performed pre-LED, and at 1 week, and 1 and 2 months after the 18th treatment.

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Longitudinal cognitive changes in traumatic brain injury

Cited by 197 publications

References 36 publications

Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

Functional outcome 10 years after traumatic brain injury: Its relationship with demographic, injury severity, and cognitive and emotional status

Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study

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