Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults

Donovan, Nancy J.; Locascio, Joseph J.; Marshall, Gad A.; Gatchel, Jennifer R.; Hanseeuw, Bernard; Rentz, Dorene M.; Johnson, Keith A.; Sperling, Reisa A.

doi:10.1176/appi.ajp.2017.17040442

Cited by 198 publications

(138 citation statements)

References 37 publications

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“…Affective symptoms in subjective cognitive decline show increased risk of progression to mild cognitive impairment and dementia, suggesting the subthreshold symptoms of depres-sion as a possible manifestation of preclinical Alzheimer disease in these people. 40,41 Conversely, our analyses in a subgroup with cerebrospinal fluid biomarkers showed that the association between white matter hyperintensities and depressive symptoms is not influenced by Alzheimer disease pathology. To investigate whether factors other than white matter hyperintensity and Alzheimer disease pathology could explain these results, research in other cohorts is needed to provide more evidence.…”

Section: J Psychiatry Neurosci 2019;44(4)mentioning

confidence: 57%

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

Leeuwis¹,

Weaver²,

Biesbroek³

et al. 2019

jpn

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Background: We investigated the association between white matter hyperintensity location and depressive symptoms in a memoryclinic population using lesion-symptom mapping. Methods: We included 680 patients with vascular brain injury from the TRACE-VCI cohort (mean age ± standard deviation: 67 ± 8 years; 52% female): 168 patients with subjective cognitive decline, 164 with mild cognitive impairment and 348 with dementia. We assessed depressive symptoms using the Geriatric Depression Scale. We applied assumptionfree voxel-based lesion-symptom mapping, adjusted for age, sex, total white matter hyperintensity volume and multiple testing. Next, we applied exploratory region-of-interest linear regression analyses of major white matter tracts, with additional adjustment for diagnosis. Results: Voxel-based lesion-symptom mapping identified voxel clusters related to the Geriatric Depression Scale in the left corticospinal tract. Region-of-interest analyses showed no relation between white matter hyperintensity volume and the Geriatric Depression Scale, but revealed an interaction with diagnosis in the forceps minor, where larger regional white matter hyperintensity volume was associated with more depressive symptoms in subjective cognitive decline (β = 0.26, p < 0.05), but not in mild cognitive impairment or dementia. Limitations: We observed a lack of convergence of findings between voxel-based lesion-symptom mapping and region-of-interest analy ses, which may have been due to small effect sizes and limited lesion coverage despite the large sample size. This warrants replication of our findings and further investigation in other cohorts. Conclusion: This lesion-symptom mapping study in depressive symptoms indicates the corticospinal tract and forceps minor as strategic tracts in which white matter hyperintensity is associated with depressive symptoms in memory-clinic patients with vascular brain injury. The impact of white matter hyperintensity on depressive symptoms is modest, but it appears to depend on the location of white matter hyperintensity and disease severity.

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Section: J Psychiatry Neurosci 2019;44(4)mentioning

confidence: 57%

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

Leeuwis¹,

Weaver²,

Biesbroek³

et al. 2019

jpn

View full text Add to dashboard Cite

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“…These should include newer biomarkers, as guided by fundamental scientific insights. An amyloid-PET-based study has yielded similar results (i.e., showing no clear link with amyloid pathology) when evaluating hippocampal atrophy in a cohort of depressed people and matched controls (De Winter et al, 2017), even though others have pointed out that amyloid-positive individuals do have a tendency to progressively manifest more neuropsychiatric symptoms (Harrington et al, 2017;Donovan et al, 2018). It is clear that further research efforts could and should use the newer antemortem diagnostic techniques (e.g., LP and/or PET) to add to these findings.…”

Section: Results Are Listed Inmentioning

confidence: 96%

Depressive Symptoms in the Elderly—An Early Symptom of Dementia? A Systematic Review

2020

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“…Other studies have shown that subjects with depression have a higher incidence of MCI (Muller et al, 2007;Ng et al, 2009). Depressive patients have more amyloid abnormalities than non-depressive patients (Donovan et al, 2018) MCI with Aβ burden of the brain is associated with an increased risk of having neuropsychiatric symptoms (Krell-Roesch et al, 2019). Individuals with MCI are at an increased risk of progression to more severe cognitive impairment (Mitchell and Shiri-Feshki, 2009) and can have subtle impairments in everyday functioning (Hughes et al, 2012) and co-occurring depressive symptoms (Byers and Yaffe, 2011).…”

Section: Patients Have Higher Rates Of Depressionmentioning

confidence: 99%

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

2020

Front. Aging Neurosci.

191

157

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Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer's disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study's objective is to review the prevalence, neuropsychological characteristics, and conversion rates to dementia between MCI patients with and without depression, anxiety, and apathy.Methods: A PubMed search and critical review were performed relating to studies of MCI, depression, anxiety, and apathy.Results: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and Implications: Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.

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Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults

Cited by 198 publications

References 37 publications

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

Depressive Symptoms in the Elderly—An Early Symptom of Dementia? A Systematic Review

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

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