Longitudinal assessment of anti-SARS-CoV-2 antibody dynamics and clinical features following convalescence from a COVID-19 infection

Abstract

Introduction Longevity of anti-SARS-CoV-2 antibody level and duration of immunity are current topics of major scientific interest. Antibody kinetics during the acute phase are well-studied, whereas long-term kinetics are yet to be determined and available studies are controversial. Here, results of longitudinal analysis of serological responses to SARS-CoV-2 infection after convalescent and its association with post-COVID syndrome (PCS) are reported. Material and Methods 237 serum samples were prospectively collected from 61 SARS-CoV-2 qRT-PCR-confirmed participants. Anti-SARS-CoV-2 anti-N and anti-RBD/S1 Ig level were serially determined until 8 months after study inclusion. COVID-19 associated symptoms were assessed by a standardized questionnaire at study entry and after 6 months. Results Antibodies were detectable for 56/61 participants. Within the follow-up period, no substantial decline in the anti-SARS-CoV-2 pan-Ig levels were observed. In general, antibody levels were positively correlated with disease severity, BMI, fever, and nonsmoker status. 46.8% of the participants suffered from PCS, with olfactory and gustatory dysfunctions reported most frequently. Conclusion Study result point to stable anti-SARS-CoV-2 antibody titers and thus may indicate a long-lasting immunity. These results are in line with recently published data, and add further insights concerning asymptomatic to mild affected patients, the association with clinical features and the frequency of PCS.

Persistence of Anti-SARS-CoV-2 Antibodies Six Months after Infection in an Outbreak with Five Hundred COVID-19 Cases in Borriana (Spain): A Prospective Cohort Study

“…Still, in other studies, age and symptoms were not associated with antibody levels [37], suggesting high variability. Also, high levels of anti-SARS-CoV IgG and neutralising antibodies were observed in COVID-19 patients with high BMI and patients with metabolic syndrome [33,[38][39][40]. These results are in line with our finding, where low BMI was associated with negative antibodies.…”

Persistence of Anti-SARS-CoV-2 Antibodies Six Months After Infection in an Outbreak With Five Hundred COVID-19 Cases in Borriana (Spain): A Prospective Cohort Study

“…Still, in other studies, age and symptoms were not associated with antibody levels [37], suggesting high variability. Also, high levels of anti-SARS-CoV IgG and neutralising antibodies were observed in COVID-19 patients with high BMI and patients with metabolic syndrome [33,[38][39][40]. These results are in line with our finding, where low BMI was associated with negative antibodies.…”

Post-SARS-CoV-2 vaccination specific antibody decrease : Let's get the half-full glass perspective

“…In previously seropositive vaccinated healthcare workers, Tré-Hardy et al ( 2 ) described stable levels over 400 U/mL at 3 months. A comparable result was observed in convalescent patients by Gerhards et al ( 7 ) showing sustained levels up to 1 000 U/mL with little variation over 3 months. What Favresse and al.…”