Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit

Abstract

We investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of the aging process, henceforth referred to as dynamic organism state indicator (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 − 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.

Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors

“…On the other hand, men who resided in 1–2 room public housing who were also smokers had significantly accelerated biological aging. This finding supports the extant literature showing that low-SES individuals may be more susceptible to engage in unhealthy stress-reducing behaviors, such as smoking [ 13 , 16 ], leading to accelerated biological aging [ 48 , 50 ]. Due to the low percentage (3.2%) of women who smoked, compared to 21.3% of men who were smokers ( p < 0.001), future studies comprising more balanced smoker percentages between men and women are warranted to further examine the moderating effects of smoking status.…”

“…We have also previously shown that several of the BA biomarkers could be improved by non-pharmacological interventions [ 20 , 67 , 68 ]. Furthermore, data gathered from consumer-grade mobile and wearable device or sensor may prove as a useful tool to enroll even larger cohorts in studies of aging, as our recent work showed notable concordance between BA in blood test and wearable sensor data [ 50 , 69 , 70 ]. Taken together, the identifications of social and behavioral determinants of health and their associations with accelerated biological aging could highlight novel targets and approaches to preventing and closing the gaps of health disparity in low-SES communities, with the potential to inform and positively impact policies and interventions.…”

“…In this study, we employed the same approach and proposed a BA as a composite of complete blood count (CBC) and selected standard blood biochemistry parameters, a panel of easily accessible and examined clinical biomarkers. We have previously validated this BA model and the derived biological age acceleration (BAA) measure by showing their significant associations with multiple physical and mental health measures [ 49 , 50 ]. Furthermore, we showed the BA was a dynamic indicator of organism health and was thus modifiable by health behaviors, including smoking status [ 49 , 50 ].…”

“…We have previously validated this BA model and the derived biological age acceleration (BAA) measure by showing their significant associations with multiple physical and mental health measures [ 49 , 50 ]. Furthermore, we showed the BA was a dynamic indicator of organism health and was thus modifiable by health behaviors, including smoking status [ 49 , 50 ].…”

A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

“…It is also worthy of citing a concluding statement and caution by Pyrkov et al. from their dataset analysis of more than 500,000 people from Russia, UK and USA to assess biological age and the potential for extending lifespan: “The proximity of the critical point revealed in this work indicates that the apparent human lifespan limit is not likely to be improved by therapies aimed against specific chronic diseases or frailty syndrome.” ( 263 ).…”