Longitudinal airway remodeling in active and past smokers in a lung cancer screening population

Jobst, Bertram; Weinheimer, Oliver; Buschulte, Torben; Trauth, Mila; Tremper, Jan; Delorme, Stefan; Becker, Nikolaus; Motsch, Erna; Groß, Marie-Luise; Trotter, Anke; Eichinger, Monika; Kauczor, Hans‐Ulrich; Wielpütz, Mark O.

doi:10.1007/s00330-018-5890-4

Cited by 23 publications

(21 citation statements)

References 57 publications

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“…Tobacco smoking is related to pathophysiologic abnormalities of the lung, including in ammation [16][17][18], immune dysfunction and increased susceptibility to infection [19][20][21], mucus hypersecretion [22,23], genetic abnormalities [24,25], and airway remodeling [26][27][28]. Although such lung abnormalities can improve with smoking cessation, there is evidence for sustained pathophysiological abnormalities in ex-smokers [16,18].…”

Section: Discussionmentioning

confidence: 99%

Association Between Smoking Cessation and Obstructive Spirometry Pattern: A Cross-sectional Study

Yoon¹,

Lee²,

Jang³

et al. 2021

Preprint

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Smoking cessation aids in restoring lung function. However, whether long-term cessation can fully restore lung function has not been studied thoroughly, especially in Asian countries. This study aimed to evaluate the association between smoking cessation status and obstructive spirometry pattern among Koreans aged 40–79 years. In total, 6,298 men and 8,088 women aged 40–79 years from the Korea National Health and Nutrition Examination Survey (2015–2019) were analyzed for smoking cessation status, including the duration after quitting. Current-smokers showed a higher likelihood of having an obstructive spirometry pattern than never-smokers among both men (odds ratio [OR]: 3.15, 95% confidence interval [CI]: 2.32–4.29) and women (OR: 2.60, 95% CI: 1.59–4.23). In men, the effect tended to decrease with longer duration after cessation, but male ex-smokers who had quit smoking ≥ 20 years ago still showed a higher likelihood of having an obstructive spirometry pattern than male never-smokers (OR: 1.40, 95% CI: 1.05–1.89). In female ex-smokers, there was no significant association with the obstructive spirometry pattern, compared to that in female never-smokers. This study emphasizes the benefits of smoking cessation, possibility of long-lasting harm to lung function due to tobacco smoking, and importance of smoking prevention.

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Section: Discussionmentioning

confidence: 99%

Association Between Smoking Cessation and Obstructive Spirometry Pattern: A Cross-sectional Study

Yoon¹,

Lee²,

Jang³

et al. 2021

Preprint

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“…Multi-detector computed tomography is the reference modality for airway imaging, and various software tools allow the quantification of airway dimensions [ 4 – 7 , 19 ]. Computational airways measurements are still mainly used in scientific contexts, for example, in chronic obstructive pulmonary disease (COPD) [ 31 , 36 ], bronchial asthma (BA) [ 5 , 16 ], or cystic fibrosis (CF) [ 10 ]. These measurements are usually based on non-enhanced data, since intravenous iodinated contrast material influences the attenuation values of airways and thus the results of airway measurements.…”

Section: Discussionmentioning

confidence: 99%

“…Semiautomatic post-processing. The in-house software YACTA ("yet another CT analyzer"), a non-commercial scientific software, was employed as described previously [6,28,[31][32][33][34][35]. The measurements were carried out semiautomatically using the standard IBM algorithm [28] and a modified IBM.…”

Section: Animal Preparationmentioning

confidence: 99%

Optimizing airway wall segmentation and quantification by reducing the influence of adjacent vessels and intravascular contrast material with a modified integral-based algorithm in quantitative computed tomography

et al. 2020

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Introduction Quantitative analysis of multi-detector computed tomography (MDCT) plays an increasingly important role in assessing airway disease. Depending on the algorithms used, airway dimensions may be over-or underestimated, primarily if contrast material was used. Therefore, we tested a modified integral-based method (IBM) to address this problem. Methods Temporally resolved cine-MDCT was performed in seven ventilated pigs in breath-hold during iodinated contrast material (CM) infusion over 60s. Identical slices in non-enhanced (NE), pulmonary-arterial (PA), systemic-arterial (SA), and venous phase (VE) were subjected to an in-house software using a standard and a modified IBM. Total diameter (TD), lumen area (LA), wall area (WA), and wall thickness (WT) were measured for ten extra-and six intrapulmonary airways. Results The modified IBM significantly reduced TD by 7.6%, LA by 12.7%, WA by 9.7%, and WT by 3.9% compared to standard IBM on non-enhanced CT (p<0.05). Using standard IBM, CM led to a decrease of all airway parameters compared to NE. For example, LA decreased from 80.85±49.26mm 2 at NE, to 75.14±47.96mm 2 (-7.1%) at PA (p<0.001),

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“…2(d)]. [25][26][27] Measured dimensions of the inner diameters (ID), wall thicknesses (WT), and outer diameters (OD) from micro-CT and clinical CT images were compared with corresponding nominal values. To determine the inter-sample variance from the manufacturing process, 95% confidence/99% coverage tolerance intervals of each measurement type (ID/WT/OD) were calculated for deviations across all 10 mini-lung-phantoms from micro-CT images.…”

Section: D | Dimensional Analyses Of Simulated Airway Tubesmentioning

confidence: 99%

A calibration CT mini‐lung‐phantom created by 3‐D printing and subtractive manufacturing

Guo

Persson

Weinheimer

et al. 2021

J Applied Clin Med Phys

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We describe the creation and characterization of a calibration CT mini‐lung‐phantom incorporating simulated airways and ground‐glass densities. Ten duplicate mini‐lung‐phantoms with Three‐Dimensional (3‐D) printed tubes simulating airways and gradated density polyurethane foam blocks were designed and built. Dimensional accuracy and CT numbers were measured using micro‐CT and clinical CT scanners. Micro‐CT images of airway tubes demonstrated an average dimensional variation of 0.038 mm from nominal values. The five different densities of incorporated foam blocks, simulating ground‐glass, showed mean CT numbers (±standard deviation) of −897.0 ± 1.5, −844.1 ± 1.5, −774.1 ± 2.6, −695.3 ± 1.6, and −351.0 ± 3.7 HU, respectively. Three‐Dimensional printing and subtractive manufacturing enabled rapid, cost‐effective production of ground‐truth calibration mini‐lung‐phantoms with low inter‐sample variation that can be scanned simultaneously with the patient undergoing lung quantitative CT.

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Longitudinal airway remodeling in active and past smokers in a lung cancer screening population

Cited by 23 publications

References 57 publications

Association Between Smoking Cessation and Obstructive Spirometry Pattern: A Cross-sectional Study

Association Between Smoking Cessation and Obstructive Spirometry Pattern: A Cross-sectional Study

Optimizing airway wall segmentation and quantification by reducing the influence of adjacent vessels and intravascular contrast material with a modified integral-based algorithm in quantitative computed tomography

A calibration CT mini‐lung‐phantom created by 3‐D printing and subtractive manufacturing

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