Longifoamide-A and B: Two new ceramides from <i>Mentha longifolia</i> (Lamiaceae)

Ali, Muhammad; Ahmed, Waqar; Saleem, Muhammad; Khan, Taous

doi:10.1080/14786410500445186

Cited by 8 publications

(2 citation statements)

References 18 publications

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“…The leaves are used for making chutney throughout India and are considered to be a stimulant, carminative, antispasmodic, and diuretic. It is also used for gas pain, rheumatism, muscle pain, and mouthwash (Shaiq Ali et al, 2006). The herb contains an essential oil used in chewing gums, toothpastes, confectionery, and pharmaceutical preparation (Choudhury et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxic and antioxidant potential of aqueous fraction of ethanol extract ofMentha spicata(L.) against 4-nitroquinoline-1-oxide–induced chromosome damage in mice

Arumugam

Ramesh

2009

Drug and Chemical Toxicology

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The antigenotoxic potential of an aqueous fraction of ethanol extract of Mentha spicata was evaluated by measuring the frequency of micronucleated polychromatic erythrocytes (MnPCEs) in mice bone marrow, using 4-nitroquinoline-1oxide (NQO) as the reference mutagen. In addition, lipid peroxidation (LPO) and antioxidant levels were also quantified with liver tissue of the same mice to assess their antioxidant potential. Swiss albino mice of either sex (25-30 g) were orally pretreated with an aqueous fraction (80, 160, and 320 mg/kg) for 5 consecutive days. NQO (7.5 mg/kg) was injected intraperitoneally after 2 hours until the final day (day 5) of treatment with aqueous fraction. Animals were sacrificed 24 hours later by cervical dislocation and processed for micronuclei and bioassays. A significant reduction (about 67%) of NQO-induced MnPCE frequency was observed at the dose of 320 mg/kg. The LPO was also suppressed effectively, with concomitant changes in both enzymatic and nonenzymatic antioxidants. The restoration level was dose dependent in LPO and glutathione-s-transferase, whereas it was dose independent in superoxide dismutase, glutathione peroxidase, catalase, and reduced glutathione. The results indicate that the aqueous fraction of M. spicata mediates their antigenotoxic effects by the modulation of LPO and antioxidant enzymes.

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Section: Introductionmentioning

confidence: 99%

Antigenotoxic and antioxidant potential of aqueous fraction of ethanol extract ofMentha spicata(L.) against 4-nitroquinoline-1-oxide–induced chromosome damage in mice

Arumugam

Ramesh

2009

Drug and Chemical Toxicology

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“…Mentha spicata L. (Lamiaceae) is commonly known as spearmint and in India as “ Pudina ” (Ali et al , 2006). The leaves are well recognized for making a herbal tea and for use in the preparation of folk medicine (Carmona et al , 2005; Adsersen et al , 2006).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of solvent fractions of Mentha spicata (L.) leaves evaluated on 4-nitroquinoline-1-oxide induced chromosome damage and apoptosis in mouse bone marrow cells

Arumugam

Ramesh

2009

Genet. Mol. Biol.

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Spearmint leaves (Mentha spicata L.) contain high levels of antioxidants that are known to protect against both exogenous and endogenous DNA damage. In this study, the protective effects of the hexane fraction (HF), chloroform fraction (CF) and ethyl acetate fraction (EAF) in an ethanol extract from M. spicata were evaluated against 4-nitroquinoline-1-oxide (4-NQO) induced chromosome damage and apoptosis in bone marrow cells of Swiss albino mice. Two (EAF; 80 and 160 mg/ kg body weight -bw) or three (HF and CF; 80, 160 and 320 mg/ kg bw) doses of solvent fractions or vehicle control (25% DMSO in water) were administered orally for five consecutive days. Upon the sixth day, 4-NQO was injected intraperitoneally. The animals were killed the following day. Other control groups were comprised of animals treated with either the vehicle control or the various doses of solvent fractions, but with no 4-NQO treatment. 4-NQO induced micro-nucleated polychromatic erythrocytes (MnPCEs) in all the test groups. However, pre-treatment of animals with the solvent fractions significantly reduced the 4-NQO-induced MnPCEs as well as the percentage of apoptotic cells. The reduction of both MnPCE and apoptosis was more evident following the pre-treatment of animals with 160 mg/kg bw EAF.

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Review of available “extraction + purification” methods of natural ceramides and their feasibility for sewage sludge analysis

Zhu

Zhao

et al. 2023

Environ Sci Pollut Res

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Longifoamide-A and B: Two new ceramides from Mentha longifolia (Lamiaceae)

Cited by 8 publications

References 18 publications

Antigenotoxic and antioxidant potential of aqueous fraction of ethanol extract ofMentha spicata(L.) against 4-nitroquinoline-1-oxide–induced chromosome damage in mice

Antigenotoxic and antioxidant potential of aqueous fraction of ethanol extract ofMentha spicata(L.) against 4-nitroquinoline-1-oxide–induced chromosome damage in mice

Protective effects of solvent fractions of Mentha spicata (L.) leaves evaluated on 4-nitroquinoline-1-oxide induced chromosome damage and apoptosis in mouse bone marrow cells

Review of available “extraction + purification” methods of natural ceramides and their feasibility for sewage sludge analysis

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