2020
DOI: 10.1111/acel.13139
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Abstract: Loci associated with longevity are likely to harbor genes coding for key players of molecular pathways involved in a lifelong decreased mortality and decreased/compressed morbidity. However, identifying such loci is challenging. One of the most plausible reasons is the uncertainty in defining long‐lived cases with the heritable longevity trait among long‐living phenocopies. To avoid phenocopies, family selection scores have been constructed, but these have not yet been adopted as state of the art in longevity … Show more

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Cited by 12 publications
(14 citation statements)
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References 60 publications
(142 reference statements)
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“…However, few genetic variants associated with longevity have been identified (Deelen et al, 2019), potentially because of rare variants and “phenocopies,” that is, individuals that live long by chance. Using Dutch historical data, van der Berg et al (2020) recently showed that longevity is transmitted for at least two subsequent generations only when at least 20% of all relatives are long‐lived. This is in line with our results and suggests that longevity‐enriched families can be a powerful study sample for facilitating the discovery of novel genetic variants promoting exceptional health and survival—not only rare variants unique to the family but also common variants.…”
Section: Discussionmentioning
confidence: 99%
“…However, few genetic variants associated with longevity have been identified (Deelen et al, 2019), potentially because of rare variants and “phenocopies,” that is, individuals that live long by chance. Using Dutch historical data, van der Berg et al (2020) recently showed that longevity is transmitted for at least two subsequent generations only when at least 20% of all relatives are long‐lived. This is in line with our results and suggests that longevity‐enriched families can be a powerful study sample for facilitating the discovery of novel genetic variants promoting exceptional health and survival—not only rare variants unique to the family but also common variants.…”
Section: Discussionmentioning
confidence: 99%
“…lifestyle, environment, and social network), as well as their interactions are involved in human longevity. It has been estimated that age at death (lifespan) attributes for ~25% to genetic variation and this number rises for long-lived individuals as shown by its strong familial clustering [ 4 , 5 ]. Nevertheless, two decades of genetic research to understand the mechanisms of longevity and healthy aging had limited robust results.…”
mentioning
confidence: 99%
“…One of the main reasons for the difficulty of identifying genes promoting longevity and healthy aging is the lack of a consistent definition for heritable longevity, which resulted in a mix of sporadically long-lived cases with those descending from a long-lived family and a large variation of longevity definitions used in longevity research [ 4 , 5 ]. The presence of sporadically long-lived cases is illustrated by the increase of centenarians in the United States between 1994 and 2012 from 1 in 10,000 to 2 in 10,000.…”
mentioning
confidence: 99%
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