Longevity: Lesson from Model Organisms

Taormina, Giusi; Ferrante, F.; Vieni, Salvatore; Grassi, Nello; Russo, Antonio; Mirisola, Mario G.

doi:10.3390/genes10070518

Cited by 73 publications

(60 citation statements)

References 191 publications

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“…1). Comparing to efficacy of known pro-longevity manipulations (34)(35)(36), the overall effects provided by youth impacts were modest. However, similar to the lifespan extension mediated by the reduction of caloric intake (37,38) (43).…”

Section: Discussionmentioning

confidence: 76%

Social Perception of Young Adults Prolongs the Lifespan of Aged Drosophila

Cho

Kao

2020

Preprint

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Lifespan is modulated at distinct levels by multiple factors, including genetic backgrounds, the environment, behavior traits, the metabolic status, and more interestingly, the sensory perceptions. However, the effects of social perception between individuals living in the same space remain less clear. Here, we used the Drosophila model to study the influences of social perception on the lifespan of aged fruit flies. We found the mean lifespan of aged Drosophila is markedly prolonged after being co-housed with young adults of the same gender. Moreover, the changes of lifespan were affected by several experimental contexts: (1) the ratios of aged and young adults co-housed, (2) the chronological ages of two populations, and (3) the integrity of sensory modalities. Together, we hypothesize the chemical/physical stimuli derived from the interacting young adults are capable of interfering with the physiology and behavior of aged flies, ultimately leading to the alteration of lifespan.

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Section: Discussionmentioning

confidence: 76%

Social Perception of Young Adults Prolongs the Lifespan of Aged Drosophila

Cho

Kao

2020

Preprint

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“…There are many reasons why animal studies are essential to medical progress. All mammals descend from common ancestors and all species have a similar set of organs that function in essentially the same way 5 . Animals and humans are biologically similar; therefore, they are susceptible to similar pathologies.…”

Section: Significance Of Animal Researchmentioning

confidence: 99%

“…From the practical point of view, many experimental species studied, such as rodents, often make better research subjects than human beings due to their shorter life cycles, easy handling accessible animal housing, etc 5 . Under laboratory conditions, rodents have a lifespan of 2-3 years, so researchers can conduct studies throughout their live cycle or even for several generations.…”

Section: Significance Of Animal Researchmentioning

confidence: 99%

“…The emphasis in modern medicine is now learning toward health throughout life and is now clear that adverse early events -even before birth -can greatly impair life-course health and shorten the lifespan. Therefore, the focus is moving toward maintaining a healthy span rather than expanding the life span 5,13 . A better knowledge of metabolic, cardiovascular, and neurological processes can also help improving health span in animals.…”

Section: Significance Of Animal Researchmentioning

confidence: 99%

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Ethical Considerations in Animal Research: The Principle of 3R's

Dı́az¹,

Zambrano²,

Flores³

et al. 2021

RIC

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In the last century, progress in the knowledge of human diseases, their diagnosis and treatment have grown exponentially, due in large part to the introduction and use of laboratory animals. Along with this important progress, the need to provide training and guidance to the scientific community in all aspects related to the proper use of experimental animals has been indispensable. Animal research committees play a primary role in evaluating experimental research protocols, from their feasibility to the rational use of animals, but above all in seeking animal welfare. The Institutional Committee for the Care and Use of Animals (IACUC) has endeavored to share several relevant aspects in conducting research with laboratory animals. Here, we present and discuss the topics that we consider of utmost importance to take in the account during the design of any experimental research protocol, so we invite researchers, technicians, and undergraduate and graduate students to dive into the fascinating subject of proper animal care and use for experimentation. The main intention of these contributions is to sensitize users of laboratory animals for the proper and rational use of them in experimental research, as well as to disseminate the permitted and unpermitted procedures in laboratory animals. In the first part, the significance of experimental research, the main functions of IACUC, and the principle of the three R's (replacement, reduction, and refinement) are addressed.

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“…IGF-1 signaling is involved in the regulation of cell proliferation, stress resistance, apoptosis and tumorigenesis, and decreased IGF-1 level is proved to be lifespan beneficial. Studies in dogs have proved that animals with lower circulating IGF-1 levels tend to have smaller body size and longer lifespan [41,42]. A basic aging theory claims that GH decreases lifespan and that lifespan benefits of DR regimens are attributed to reduced growth stimulation [43,44].…”

Section: Signaling Network Of Foxo In Dr: Insulin/igf-1 Signaling Pamentioning

confidence: 99%

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Jiang

Yan

Feng

et al. 2019

Cells

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Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal. However, the molecular mechanisms by which DR confers benefits on longevity were not yet fully elucidated. The forkhead box O transcription factors (FOXOs), identified as downstream regulators of the insulin/IGF-1 signaling pathway, control the expression of many genes regulating crucial biological processes such as metabolic homeostasis, redox balance, stress response and cell viability and proliferation. The activity of FOXOs is also mediated by AMP-activated protein kinase (AMPK), sirtuins and the mammalian target of rapamycin (mTOR). Therefore, the FOXO-related pathways form a complex network critical for coordinating a response to environmental fluctuations in order to maintain cellular homeostasis and to support physiological aging. In this review, we will focus on the role of FOXOs in different DR interventions. As different DR regimens or calorie (energy) restriction mimetics (CRMs) can elicit both distinct and overlapped DR-related signaling pathways, the benefits of DR may be maximized by combining diverse forms of interventions. In addition, a better understanding of the precise role of FOXOs in different mechanistic aspects of DR response would provide clear cellular and molecular insights on DR-induced increase of lifespan and health-span.

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Longevity: Lesson from Model Organisms

Cited by 73 publications

References 191 publications

Social Perception of Young Adults Prolongs the Lifespan of Aged Drosophila

Social Perception of Young Adults Prolongs the Lifespan of Aged Drosophila

Ethical Considerations in Animal Research: The Principle of 3R's

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

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