Longer term effects of the Angelina Jolie effect: increased risk-reducing mastectomy rates in BRCA carriers and other high-risk women

Evans, D. Gareth; Wisely, Julie; Clancy, Tara; Lalloo, Fiona; Wilson, Mary; Johnson, Richard K.; Duncan, Jonathon; Barr, Lester; Gandhi, Ashu; Howell, Anthony

doi:10.1186/s13058-015-0650-8

Cited by 81 publications

(60 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, rates of mastectomy among women who tested positive for the BRCA mutation could have increased after the time captured by our study period. 9 10 Finally, although our study population was more general than that of previous studies, certain …”

Section: Discussionmentioning

confidence: 90%

Do celebrity endorsements matter? Observational study of BRCA gene testing and mastectomy rates after Angelina Jolie’s New York Times editorial

Desai

Jena

2016

BMJ

View full text Add to dashboard Cite

Objective To examine the effect on BRCA testing and mastectomy rates of a widely viewed 2013 New York Times editorial by public figure Angelina Jolie that endorsed BRCA testing and announced Jolie’s decision to undergo preventive mastectomy.Design Observational study with difference-in-difference analysis.Setting Commercially insured US population.Participants Women aged 18-64 years with claims in the Truven MarketScan commercial claims database (n=9 532 836).Main outcome measures Changes in BRCA testing rates in the 15 business days before versus after 14 May 2013 (editorial date) compared with the change in the same period in 2012; mastectomy rates in the months before and after publication, both overall and within 60 days of BRCA testing among women who were tested; national estimates of incremental tests and expenditures associated with Jolie’s article in the 15 days after publication.Results Daily BRCA test rates increased immediately after the 2013 editorial, from 0.71 tests/100 000 women in the 15 business days before to 1.13 tests/100 000 women in the 15 business days after publication. In comparison, daily test rates were similar in the same period in 2012 (0.58/100 000 women in the 15 business days before 14 May versus 0.55/100 000 women in the 15 business days after), implying a difference-in-difference absolute daily increase of 0.45 tests/100 000 women or a 64% relative increase (P<0.001). The editorial was associated with an estimated increase of 4500 BRCA tests and $13.5m (£10.8m; €12.8) expenditure nationally among commercially insured adult women in those 15 days. Increased BRCA testing rates were sustained throughout 2013. Overall mastectomy rates remained unchanged in the months after publication, but 60 day mastectomy rates among women who had a BRCA test fell from 10% in the months before publication to 7% in the months after publication, suggesting that women who underwent tests as a result of to the editorial had a lower pre-test probability of having the BRCA mutation than women tested before the editorial.Conclusions Celebrity endorsements can have a large and immediate effect on use of health services. Such announcements can be a low cost means of reaching a broad audience quickly, but they may not effectively target the subpopulations that are most at risk for the relevant underlying condition.

show abstract

Section: Discussionmentioning

confidence: 90%

Do celebrity endorsements matter? Observational study of BRCA gene testing and mastectomy rates after Angelina Jolie’s New York Times editorial

Desai

Jena

2016

BMJ

View full text Add to dashboard Cite

show abstract

“…A U.K. study reported the impact of Jolie's announcement on RRM rates within their network (Evans et al. ). However, the external validity of this study, particularly on a global scale, remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…One U.K. study examined the occurrence of RRM within a health network and reported higher rates of RRM following Jolie's announcement (Evans et al. ). It was unknown whether this was a U.K.‐specific or global phenomenon, warranting examination across different populations and health systems.…”

mentioning

confidence: 99%

Trends in Use of Risk‐Reducing Mastectomy in a Context of Celebrity Decisions and Media Coverage: An Observational Study in the United States and Australia

Mao

Jorm

Sedrakyan

2017

Health Services Research

View full text Add to dashboard Cite

show abstract

“…The popularity of genetic testing for BRCA1 and BRCA2 mutations has increased significantly after the media coverage of Angeline Jolie's case, and the presence of these mutations has led to an increase in the number of unilateral or bilateral mastectomies followed by reconstruction, either immediately or at a distance of time (20).…”

mentioning

confidence: 99%

Breast Cancer Surgery

Blidaru¹

2017

chr

View full text Add to dashboard Cite

Breast cancer treatment has been constantly improving over the past decades and the consequences of this have been an increase in survival and improvements in the quality of life of these patients. The main reasons for this are early screening and diagnosis, more accurate characterization of mammary tumours by histopathological, molecular and genomic examination in order to obtain a personalized treatment, the emergence of new molecules for systemic treatment, the improvement of radiotherapy and the progress of surgical techniques.The "modern" history of breast cancer surgery begins, of course, with W. Halsted and the radical mastectomy type of surgery that bears his name, and which has been for nearly 50 years synonymous with the surgical treatment of breast cancer. This surgery represented the model to be followed for radical cancer treatment.Attempts at supraradical mastectomy proposed by DahlIversen, Wangesteen, and Urban did not improve survival, and were quickly abandoned due to increased morbidity and mortality. The transition from radical mastectomy to successive forms of modified mastectomy was surprisingly slow, with every change virtually representing a revolution, even if these changes in technique were not paradigm replacements, as they were in fact faithful to the same Halstedian concept of oncological radicality. Their common desideratum was complete axillary dissection, striving to achieve this by initially preserving the pectoralis major muscle, then both major and minor pectoralis muscles. Halsted mastectomy was replaced by Patey and afterwards by Madden technique, the latter being at present the most commonly used mastectomy type (1).

show abstract

Longer term effects of the Angelina Jolie effect: increased risk-reducing mastectomy rates in BRCA carriers and other high-risk women

Cited by 81 publications

References 5 publications

Do celebrity endorsements matter? Observational study of BRCA gene testing and mastectomy rates after Angelina Jolie’s New York Times editorial

Do celebrity endorsements matter? Observational study of BRCA gene testing and mastectomy rates after Angelina Jolie’s New York Times editorial

Trends in Use of Risk‐Reducing Mastectomy in a Context of Celebrity Decisions and Media Coverage: An Observational Study in the United States and Australia

Breast Cancer Surgery

Contact Info

Product

Resources

About