Longchain polyunsaturated fatty acid supplementation in preterm infants

Abstract

Longchain polyunsaturated fatty acid supplementation in preterm infants (Review)

Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial

“…Our finding of enhanced eye and hand coordination with fish oil supplementation is plausible and consistent with previously reported benefits on visual function after postnatal n-3 PUFA supplementation in both preterm14 24 and term15 25 infants. Although the underlying mechanism is not understood, DHA is known to facilitate rapid phototransduction in the retinal membrane,26 and deficiencies are associated with reduced retinal function in infant primates 2.…”

Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial

“…Our finding of enhanced eye and hand coordination with fish oil supplementation is plausible and consistent with previously reported benefits on visual function after postnatal n-3 PUFA supplementation in both preterm14 24 and term15 25 infants. Although the underlying mechanism is not understood, DHA is known to facilitate rapid phototransduction in the retinal membrane,26 and deficiencies are associated with reduced retinal function in infant primates 2.…”

Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial

“…A systematic review and meta-analysis of LCPUFA trials in preterm infants concluded that LCPUFA-supplemented formula may enhance anthropometric measures of preterm infants at 2 mo of age (28) compared with infants fed formula with no LCPUFA; however, growth of males and females were not examined separately. In the present trial, the increases in the weight and length of females fed the high-dose DHA intervention compared with the control intervention are consistent with the overall findings of the systematic review (28). However, differences in growth measures only in the female subgroup should be interpreted with caution because of the reduced sample size.…”

Impact of Breast Milk on Intelligence Quotient, Brain Size, and White Matter Development

“…In recent years, long-chain polyunsaturated fatty acids (LCPUFAs), notably docosahexaenoic acid (DHA), have been considered a key explanation for neurodevelopmental benefits of breast milk. A recent meta-analysis of outcome in preterms after early LCPUFA supplementation of infant formula (27), however, found no conclusive evidence for long-term cognitive effects, suggesting that differences in early LCPUFA intake may not explain our observations. While LCPUFAs remain of interest, it should be remembered that human milk contains a wide variety of other factors including hormones and growth factors, some of which (e.g.…”

Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial

“…Our finding of enhanced eye and hand coordination with fish oil supplementation is plausible and consistent with previously reported benefits on visual function after postnatal n-3 PUFA supplementation in both preterm14 24 and term15 25 infants. Although the underlying mechanism is not understood, DHA is known to facilitate rapid phototransduction in the retinal membrane,26 and deficiencies are associated with reduced retinal function in infant primates 2.…”

Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial

“…A systematic review and meta-analysis of LCPUFA trials in preterm infants concluded that LCPUFA-supplemented formula may enhance anthropometric measures of preterm infants at 2 mo of age (28) compared with infants fed formula with no LCPUFA; however, growth of males and females were not examined separately. In the present trial, the increases in the weight and length of females fed the high-dose DHA intervention compared with the control intervention are consistent with the overall findings of the systematic review (28). However, differences in growth measures only in the female subgroup should be interpreted with caution because of the reduced sample size.…”

Impact of Breast Milk on Intelligence Quotient, Brain Size, and White Matter Development

“…In recent years, long-chain polyunsaturated fatty acids (LCPUFAs), notably docosahexaenoic acid (DHA), have been considered a key explanation for neurodevelopmental benefits of breast milk. A recent meta-analysis of outcome in preterms after early LCPUFA supplementation of infant formula (27), however, found no conclusive evidence for long-term cognitive effects, suggesting that differences in early LCPUFA intake may not explain our observations. While LCPUFAs remain of interest, it should be remembered that human milk contains a wide variety of other factors including hormones and growth factors, some of which (e.g.…”

Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial

“…Our finding of enhanced eye and hand coordination with fish oil supplementation is plausible and consistent with previously reported benefits on visual function after postnatal n-3 PUFA supplementation in both preterm14 24 and term15 25 infants. Although the underlying mechanism is not understood, DHA is known to facilitate rapid phototransduction in the retinal membrane,26 and deficiencies are associated with reduced retinal function in infant primates 2.…”

Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial

“…A systematic review and meta-analysis of LCPUFA trials in preterm infants concluded that LCPUFA-supplemented formula may enhance anthropometric measures of preterm infants at 2 mo of age (28) compared with infants fed formula with no LCPUFA; however, growth of males and females were not examined separately. In the present trial, the increases in the weight and length of females fed the high-dose DHA intervention compared with the control intervention are consistent with the overall findings of the systematic review (28). However, differences in growth measures only in the female subgroup should be interpreted with caution because of the reduced sample size.…”

Impact of Breast Milk on Intelligence Quotient, Brain Size, and White Matter Development

“…In recent years, long-chain polyunsaturated fatty acids (LCPUFAs), notably docosahexaenoic acid (DHA), have been considered a key explanation for neurodevelopmental benefits of breast milk. A recent meta-analysis of outcome in preterms after early LCPUFA supplementation of infant formula (27), however, found no conclusive evidence for long-term cognitive effects, suggesting that differences in early LCPUFA intake may not explain our observations. While LCPUFAs remain of interest, it should be remembered that human milk contains a wide variety of other factors including hormones and growth factors, some of which (e.g.…”