2015
DOI: 10.1002/ar.23177
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Abstract: In Duchenne muscle dystrophy (DMD) and in the mdx mouse model of DMD, a lack of dystrophin leads to myonecrosis and cardiorespiratory failure. Several lines of evidence suggest a detrimental role of the inflammatory process in the dystrophic process. Previously, we demonstrated that short-term therapy with eicosapentaenoic acid (EPA), at early stages of disease, ameliorated dystrophy progression in the mdx mouse. In the present study, we evaluated the effects of a long-term therapy with omega-3 later in dystro… Show more

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Cited by 19 publications
(16 citation statements)
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“…Many researchers have investigated various dietary supplements to inhibit muscle pathology or strengthen non-diseased muscles, whether it be for athletes or against aging, type 2 diabetes, or MD [ 83 , 84 , 85 , 86 , 87 , 110 , 128 , 129 , 130 , 131 , 132 , 133 ]. In MD, increasing the percentage of slow fibers is often the goal, but not necessarily the only goal.…”
Section: Dietary Supplementsmentioning
confidence: 99%
See 1 more Smart Citation
“…Many researchers have investigated various dietary supplements to inhibit muscle pathology or strengthen non-diseased muscles, whether it be for athletes or against aging, type 2 diabetes, or MD [ 83 , 84 , 85 , 86 , 87 , 110 , 128 , 129 , 130 , 131 , 132 , 133 ]. In MD, increasing the percentage of slow fibers is often the goal, but not necessarily the only goal.…”
Section: Dietary Supplementsmentioning
confidence: 99%
“…Feeding MD hamsters flaxseed-derived omega-3 from birth until death significantly improved skeletal muscle histopathology [ 129 ]. Additional studies in mdx mice, both young [ 130 ] and old [ 131 ], benefitted from omega-3 treatment. The benefits include reduced ROS, increased grip strength, decreased fibrosis, and improved echo parameters.…”
Section: Fatty Acid Supplementsmentioning
confidence: 99%
“…Since Cx39 can be upregulated in mechanically damaged muscle (Belluardo et al, ; Frinchi et al, ), stable levels of Cx39 and NF‐kB may indicate that mild training was not detrimental to the diaphragm of mdx mice. However, other investigators have recently reported upregulation of NF‐kB in the diaphragm of mdx mice (Apolinário et al, ; Pereira et al, ), suggesting the need for further studies.…”
Section: Discussionmentioning
confidence: 95%
“…The reason we chose TBN (30 mg/kg) was that in the previously study for the therapeutic effects of TBN (10 mg/kg, 30 mg/kg, 60 mg/kg) on SOD1 G93A mouse model of amyotrophic lateral sclerosis, TBN (30 mg/kg) had the most obvious improvement in the behavior and fibrosis of SOD1 G93A mice (Not yet published). At the end of study, diaphragm (DIA) and gastrocnemius (GAS) muscles were collected for pathological evaluation because DMD present with progressive muscle degeneration of respiratory (DIA) and appendicular (GAS) muscles [15].…”
Section: Experimental Designmentioning
confidence: 99%