Long-Term Sustained Ciprofloxacin Release from PMMA and Hydrophilic Polymer Blended Nanofibers

Abstract

Nanofibers represent an attractive novel drug delivery system for prolonged and controlled release. However, sustained release of hydrophilic drugs, like ciprofloxacin hydrochloride (CIP), from polymeric nanofibers is not an easy task. The present study investigates the effect of different hydrophobic polymers (PCL and PMMA) alone in monolithic nanofibers or with hydrophilic polymers (PVA, PEO, and chitosan) in blended nanofibers aiming to achieve sustained CIP release. CIP release from PCL nanofibers was 46% and from PMMA just 1.5% over 40 day period. Thus, PMMA holds great promise for modification of CIP release from blended nanofibers. PMMA blends with 10% PEO, PVA, or chitosan were used to electrospin nanofibers from solution in the mixture of acetic and formic acid. These nanofibers exhibited different drug-release profiles: PEO containing nanofiber mats demonstrated high burst effect, chitosan containing mats revealed very slow gradual release, and PVA containing mats yielded smaller burst effect with favorable sustained release. We have also shown that gradual sustain release of antibiotic like CIP can be additionally tuned over 18 days with various blend ratios of PMMA with PVA or chitosan reaching almost 100%. A mathematical model in agreement with the experimental observation revealed that the sustained CIP release from the blended nanofibers corresponded to the two-stage desorption process.

Antibacterial Effect of Thymol Loaded SBA-15 Nanorods Incorporated in PCL Electrospun Fibers

“…However, the comparison with previous results for THY loaded PCL fibers (PCL-THY) [31] indicates an interesting improvement since a 55% of THY was released instead of less than 8%. Similar results were found for ciprofloxacin-loaded PCL fibers, where 30% of the drug was released in the first 10 h [49]. Due to the experimental protocol followed, i.e., replenishing with fresh solvent after sampling, a potential drug saturation in the solutions was ruled out.…”

Recent Developments in Antimicrobial Polymers: A Review

“…In recent years, although less explored than the strategies presented above, antibiotic delivery systems based on hydrogels [182,183,184] and nanofibers or nanofibrous mats [160,185,186,187] have been also used. Gustafson et al [183] prepared charged hydrogels based on oligo(poly(ethylene glycol)fumarate) and sodium methacrylate (OPF/SMA), by photopolymerization, and used it as a delivery device for vancomycin in surgical applications.…”

Sustained‐release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality?

“…When tetracycline was incorporated into the core‐shell of the nanofibers, the drug was released over a period of 75 days, with a burst release of 19% within the first 2 hours. Using the electrospinning technique, Zupančič et al developed biocompatible and biodegradable chitosan/polyethylene oxide nanofibers with metronidazole as the active agent. The nanofibers swelled, eroded, and gradually released the metronidazole.…”