Long-term prognostic value of late gadolinium enhancement in a cohort of patients with nonischemic dilated cardiomyopathy

Rodríguez-Capitán, Jorge; García‐Pinilla, José Manuel; Ruíz-Zamora, Isabel; Rueda-Calle, Eloy; Morcillo‐Hidalgo, Luis; Jurado-Canca, Carmen; Robledo-Carmona, Juan; Gómez‐Doblas, Juan José; Teresa–Galván, Eduardo de

doi:10.1016/j.ijcard.2014.09.110

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…In the present study, however, the presence of LGE was not a predictor for cardiac outcomes. A similar result has been obtained in other studies 31,32 . The reason of discordant results was unclear.…”

Section: Discussionsupporting

confidence: 87%

Clinical significance of left atrial geometry in dilated cardiomyopathy patients: A cardiovascular magnetic resonance study

Yazaki

Nabeta

Inomata

et al. 2020

Clinical Cardiology

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Background Clinical significance of left atrial (LA) function and geometry in patients with dilated cardiomyopathy (DCM) remains uncertain. Hypothesis LA geometric parameters assessed by cardiac magnetic resonance (CMR) predict the prognosis in patients with DCM. Methods The present study included patients with DCM and sinus rhythm who underwent CMR between December 2007 and April 2018. LA volume was measured using CMR. LA sphericity index was computed as the ratio of the measured maximum LA volume by the volume of a sphere with maximum LA length diameter. Results We included 255 patients in this study. During the mean follow‐up of 3.92 years, hospitalization for HF occurred in 37 patients. The LA sphericity index was significantly higher in patients with hospitalization for HF than in those without (0.78 ± 0.35 vs. 0.58 ± 0.18, p < .001). Multivariable Cox regression analysis identified a higher LA sphericity index as an independent predictor of hospitalization for HF. Patients were categorized based on the median of LA sphericity index. The Kaplan–Meier curve showed that patients with a high LA sphericity index (≥0.57) had a significantly higher risk of hospitalization for HF than those with a low LA sphericity index (<0.57). Conclusion LA sphericity index was an independent predictor of hospitalization for HF. Assessment of LA geometric parameters might be useful for risk stratification in patients with DCM.

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Section: Discussionsupporting

confidence: 87%

Clinical significance of left atrial geometry in dilated cardiomyopathy patients: A cardiovascular magnetic resonance study

Yazaki

Nabeta

Inomata

et al. 2020

Clinical Cardiology

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“…The majority of studies evaluated the presence or absence of LGE by visual analysis. 4,6,7,10,[13][14][15][16][17][18][19][20]22,[24][25][26][27][28][29]30,32 Duration of follow-up ranged from 1 year to 5.3 years; mean follow up was 3 years. The majority of reports considered a composite arrhythmic end-point formed by sudden cardiac death and/or aborted cardiac arrest, sustained ventricular arrhythmias and/or appropriate ICD therapies.…”

Section: Study Characteristicsmentioning

confidence: 99%

Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy

Marco

Anguera

Schmitt³

et al. 2017

JACC: Heart Failure

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Di Marco, A. et al. (2017) Late gadolinium enhancement and the risk for ventricular arrhythmias or sudden death in dilated cardiomyopathy: systematic review and meta-analysis. JACC: Heart Failure, 5(1), pp. 28-38. (doi:10.1016/j.jchf.2016.09.017) This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/133553/ Background: Risk stratification for SCD in DCM needs to be improved.

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“…Thirty studies with a total of 7541 patients reported major ventricular arrhythmic events, which occurred in 810 patients (10.7%) 4 , 9 , 16 – 19 , 25 – 28 , 31 – 33 , 35 , 37 – 39 , 42 – 44 , 46 , 51 , 57 , 60 , 62 , 63 , 66 , 68 , 71 . The pooled OR and rates of major ventricular arrhythmic events were shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four studies with a total of 5807 patients reported cardiovascular mortality, which occurred in 734 patients (12.6%) 9 , 10 , 17 , 21 , 29 – 31 , 33 , 35 , 37 – 40 , 43 , 44 , 48 , 51 , 57 , 58 , 62 , 63 , 66 , 68 , 71 . The pooled OR and rates of cardiovascular mortality were shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Impact of late gadolinium-enhanced cardiac MRI on arrhythmic and mortality outcomes in nonischemic dilated cardiomyopathy: updated systematic review and meta-analysis

Theerasuwipakorn,

Chokesuwattanaskul,

Phannajit

et al. 2023

Sci Rep

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Risk stratification based mainly on the impairment of left ventricular ejection fraction has limited performance in patients with nonischemic dilated cardiomyopathy (NIDCM). Evidence is rapidly growing for the impact of myocardial scar identified by late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (CMR) on cardiovascular events. We aim to assess the prognostic value of LGE on long-term arrhythmic and mortality outcomes in patients with NIDCM. PubMed, Scopus, and Cochrane databases were searched from inception to January 21, 2022. Studies that included disease-specific subpopulations of NIDCM were excluded. Data were independently extracted and combined via random-effects meta-analysis using a generic inverse-variance strategy. Data from 60 studies comprising 15,217 patients were analyzed with a 3-year median follow-up. The presence of LGE was associated with major ventricular arrhythmic events (pooled OR: 3.99; 95% CI 3.08, 5.16), all-cause mortality (pooled OR: 2.14; 95% CI 1.81, 2.52), cardiovascular mortality (pooled OR 2.83; 95% CI 2.23, 3.60), and heart failure hospitalization (pooled OR: 2.53; 95% CI 1.78, 3.59). Real-world evidence suggests that the presence of LGE on CMR was a strong predictor of adverse long-term outcomes in patients with NIDCM. Scar assessment should be incorporated as a primary determinant in the patient selection criteria for primary prophylactic implantable cardioverter-defibrillator placement.

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Long-term prognostic value of late gadolinium enhancement in a cohort of patients with nonischemic dilated cardiomyopathy

Cited by 10 publications

References 9 publications

Clinical significance of left atrial geometry in dilated cardiomyopathy patients: A cardiovascular magnetic resonance study

Clinical significance of left atrial geometry in dilated cardiomyopathy patients: A cardiovascular magnetic resonance study

Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy

Impact of late gadolinium-enhanced cardiac MRI on arrhythmic and mortality outcomes in nonischemic dilated cardiomyopathy: updated systematic review and meta-analysis

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