Long-term postoperative outcomes after bilateral congenital cataract surgery in eyes with microphthalmos

Praveen, Mamidipudi R.; Vasavada, Abhay R.; Shah, Sajani K.; Khamar, Mayuri; Trivedi, Rupal H.

doi:10.1016/j.jcrs.2015.10.005

Cited by 15 publications

(15 citation statements)

References 24 publications

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“…Posterior synechiae were the most frequently observed complication in our study, occurring in 21.4% of 42 microphthalmic eyes and 19.0% of normally developed eyes. In the study by Praveen et al, 37 the incidence of posterior synechiae was 27.8%, whereas Vasavada et al 21 reported a higher incidence of 35.7%. In the present study, one eye in the microphthalmos group developed glaucoma due to pupillary atresia caused by posterior synechiae.…”

Section: Discussionmentioning

confidence: 92%

“…[39][40][41][42][43][44] In the present study, the incidence of VAO was 14.3% in the microphthalmos group, which was similar to that in previous studies on microphthalmos, ranging from 5.2-16.7%. 21,37,45,46 The incidence of postoperative VAO may also vary according to differences in the individual development of pupil and surgical experience and technique among surgeons.…”

Section: Discussionmentioning

confidence: 99%

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Postoperative Complications and Axial Length Growth after Bilateral Congenital Cataract Surgery: Eyes with Microphthalmos Compared to a Comparison Group

Zhao,

Jiang,

Zhao

et al. 2023

Preprint

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Purpose: To investigate the postoperative clinical outcomes and axial length (AL) growth of infants with congenital cataracts and microphthalmos following first-stage cataract surgery. Design: Retrospective case control study Methods: Setting: Single center. Infants with congenital cataract that met the inclusion criteria were classified into two groups: the microphthalmos and comparison groups. All infants underwent a thorough ophthalmologic examination before surgery, and one week, 1 month, 3 months, and every 3 months after surgery. Results: This study enrolled 21 infants (42 eyes) in the microphthalmos group and 29 infants (58 eyes) in the comparison group. More glaucoma-related adverse events were observed in the microphthalmos group (7 eyes, 16.7%) than in the comparison group (0 eyes, 0%) (p<0.001). At each subsequent follow-up, the comparison group had a greater AL than the microphthalmos group (all p<0.001), and AL growth was significantly higher in the comparison group than in the microphthalmos group (all p=0.035). Visual acuity improved in both groups. Conclusion: Early surgical intervention improves visual function in infants with congenital cataracts and microphthalmos although with a higher incidence of glaucoma-related adverse events. After cataract removal, the AL growth of microphthalmic eyes is slower than that of normally developed eyes.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Postoperative Complications and Axial Length Growth after Bilateral Congenital Cataract Surgery: Eyes with Microphthalmos Compared to a Comparison Group

Zhao,

Jiang,

Zhao

et al. 2023

Preprint

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“…In a study by Prasad et al, [ 27 ] 5/37 microphthalmos developed glaucoma after surgery. Praveen et al, [ 28 ] showed a rate of glaucoma of 11/37. In the present study, some patients developed intraocular hypertension after surgery, and most of them were improved after conservative drug treatment.…”

Section: Discussionmentioning

confidence: 99%

Cataract surgery contributes to ocular axis growth of aphakic eyes in infants with complex microphthalmos

et al. 2020

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To observe the ocular axis, visual acuity and intraocular pressure (IOP) of aphakic eye in infants with congenital cataract and complex microphthalmos after first-stage cataract surgery. This retrospective study included infants with congenital cataract and operated at the Qingdao Eye Hospital between January 2010 and December 2014. The infants were divided into 2 groups: preoperative axial length <18 mm (microphthalmos) or ≥18 mm (controls). Follow-up lasted 24 months; visual acuity, axial length, and IOP were evaluated. There were 28 infants (55 eyes) in the microphthalmos group and 35 (61 eyes) in the control group. The preoperative visual acuity was negative for optokinetic nystagmus, while the postoperative visual acuity was positive for optokinetic nystagmus in both groups. The growth rate was higher in the microphthalmos group (1.4 ± 0.8 vs 0.8 ± 0.4 mm/yr, P < .001 vs controls). The axial length was smaller in the microphthalmos group at all time points compared with the control group (all P < .001). There was no changes in IOP in the microphthalmos group from baseline to 24 months (P = .147), but the IOP was slightly decreased in the control group ( P = .015). Cataract surgery may contribute to ocular axis growth in infants with complex microphthalmos.

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“…Authors suggested that cataract surgery in children younger than 2 years should include primary IOL implantation, associated with optic capture or bag-in-the-lens IOL implantation techniques to reduce PCO incidence (16). However, when cataract is associated with others ocular conditions as microphthalmia, IOL implantation should be delayed (21). Foldable hydrophobic acrylic is one of most used IOL material, since it remains stable and leads to less severe inflammation and PCO (22).…”

Section: Cataract Diagnosis and Managementmentioning

confidence: 99%

Recent developments in the management of congenital cataract

Brémond‐Gignac¹,

Daruich²,

Robert³

et al. 2020

Ann Transl Med

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Congenital cataract is a rare eye disease, one of the leading treatable causes of low vision in children worldwide. Hereditary cataracts can be divided in syndromic and non-syndromic cataracts. Early diagnosis in congenital cataracts is key to reach good visual function. Current surgical techniques, that combine microincision cataract extraction and primary intraocular lens (IOL) implantation, have improved childhood cataract outcome. Complications include posterior capsule opacification (PCO), aphakic or pseudophakic glaucoma, uveitis, pupil displacement and IOL decentration. A recent study using a modified Delphi approach identified areas of consensus and disagreement in the management of pediatric cataract. A consensus or near consensus was achieved for 79% of the questions, however 21% of the questions remained controversial, as for IOL implantation strategy. Congenital cataracts show a highly variable phenotype and genotype, and can be related to different mutations, genetic variance, and other risk factors. Congenital cataracts can be associated with other ocular developmental abnormalities, including microphthalmia, microcornea, or aniridia and with systemic findings. Next-generation sequencing (NGS) and forthcoming new ultra-high-throughput sequencing represent excellent tools to investigate the genetic causes of congenital cataracts. A better recognition of different clinical presentations and underlying etiologies of congenital cataracts may lead to the development of new approaches to improve visual outcome after cataract surgery and promote early detection of systemic associated syndromes.

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Long-term postoperative outcomes after bilateral congenital cataract surgery in eyes with microphthalmos

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 15 publications

References 24 publications

Postoperative Complications and Axial Length Growth after Bilateral Congenital Cataract Surgery: Eyes with Microphthalmos Compared to a Comparison Group

Postoperative Complications and Axial Length Growth after Bilateral Congenital Cataract Surgery: Eyes with Microphthalmos Compared to a Comparison Group

Cataract surgery contributes to ocular axis growth of aphakic eyes in infants with complex microphthalmos

Recent developments in the management of congenital cataract

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