Long-term Pathologic Changes of α<sub>1</sub>-Acid Glycoprotein (orosomucoid) Glycoforms in Autoimmune Thyroid Disease

Zimmermann-Belsing, Tina; Feldt‐Rasmussen, Ulla; From, Gustav; Perrild, Hans; Bøg-Hansen, T.C.

doi:10.1080/0891693021000038721

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…The associations of AGP with rheumatoid arthritis [39] and other autoimmune diseases e.g. Grave's disease [40], together with the high prevalence of these disorders in women [11] are strongly supporting the upregulation of AGP in women observed in this study. The Multiple PDZ domain protein, was the only signal transduction PPs identi ed in this study, it was up-regulated in women.…”

Section: Discussionsupporting

confidence: 85%

Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Lc-ms/ms Protein Profiling in Healthy Subjects

Giha¹,

Abdulwahab²,

Abbas³

et al. 2021

Preprint

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Sex and gender has large impact in human health and disease prediction. Men differ from women by a limited number of genes in Y chromosome while their phenotypes differ markedly. In this study, serum samples from healthy Bahraini men and women were analyzed by LC-MS/MS. Bioinformatics databases were used for proteins/peptides (PPs) identification and their gene localization. Results revealed that, the PPs which differed significantly (p<0.05 ANOVA) in abundance with fold change (FC) of ³1.5, were twenty, 11 were up-regulated in women (up to 8-folds), and 9 were up-regulated in men but with much lower FC, however, all PPs are encoded by genes located in autosomal chromosomes, indicative of sex-biased gene expression. The only PP related to sex, the sex hormone-binding globulin, was up-regulated in women. The remaining PPs were involved in immunity (6), lipid metabolism (5), gene expression (3) connective tissue (3), and others. The identified PPs were discussed within their physiological and pathological context, in relation to sex e.g. Apo-B100 (pathological cholesterol) was unregulated in men while the inflammatory/immunity related PPs, including Alpha-1-acid glycoproteins, were up-regulated in women. Finally, we propose proteomic as an ideal complementary tool for study of the molecular basis of the sex-biased gene expression.

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Section: Discussionsupporting

confidence: 85%

Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Lc-ms/ms Protein Profiling in Healthy Subjects

Giha¹,

Abdulwahab²,

Abbas³

et al. 2021

Preprint

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“…In healthy individuals, the relative proportion of the three glycoforms seems to be relatively constant, and no significant correlation to sex and age has been observed. This normal distribution of AGP glycoforms changes during acute and chronic inflammation, pregnancy, estrogen treatment, cancer, and liver damage . AGP's glycan pattern modification has also been investigated in autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of alpha‐1 acid glycoprotein and pentraxin 3 in patients with Behçet's disease and relationship with disease activity

et al. 2015

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The results of the present study demonstrate that serum levels of alpha-1 acid glycoprotein were significantly higher in patients with BD relative to the control group. Alpha-1 acid glycoprotein is greatly associated with skin lesions and arthritis in patients with BD. We did not find high serum levels of PTX3 in patients with BD compared to healthy controls, and pentraxin 3 is not associated with disease activity in BD.

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“…Additionally, it is known that glycosylation patterns of orosomucoid 2 are distinct among inflammatory and autoimmune diseases (e.g., rheumatoid arthritis, SLE, autoimmune thyroiditis, etc. ), thereby, affecting their physical properties and function 25 – 27 . Our findings may suggest the role of this protein in stimulation of proliferating T cells and regulation of local inflammation in lesional area.…”

Section: Discussionmentioning

confidence: 99%

Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata

Thanomkitti

Kanlaya

Fong-ngern

et al. 2018

Sci Rep

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Alopecia areata (AA) is one of the common hair disorders for which treatment is frequently ineffective and associated with relapsing episodes. Better understanding of disease mechanisms and novel therapeutic targets are thus required. From 10 AA patients, quantitative proteomics using LTQ-Orbitrap-XL mass spectrometer revealed 104 down-regulated, 4 absent, 3 up-regulated and 11 newly present proteins in lesional vs. non-lesional biopsies. Among these, the decreased levels of α-tubulin, vimentin, heat shock protein 70 (HSP70), HSP90, annexin A2 and α-enolase were successfully confirmed by Western blotting. Protein-protein interactions network analysis using STRING tool revealed that the most frequent biological processes/networks of the down-regulated proteins included tissue development, cell differentiation, response to wounding and catabolic process, whereas those for the up-regulated proteins included biological process, metabolic process, cellular transport, cellular component organization and response to stimulus. Interestingly, only 5 increased/newly present proteins were associated with the regulation of immune system, which may not be the predominant pathway in AA pathogenic mechanisms as previously assumed. In summary, we report herein the first proteome dataset of AA demonstrating a number of novel pathways, which can be linked to the disease mechanisms and may lead to discovery of new therapeutic targets for AA.

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Long-term Pathologic Changes of α₁-Acid Glycoprotein (orosomucoid) Glycoforms in Autoimmune Thyroid Disease

Abstract: Patients with autoimmune Graves' disease changed their relationship to AGP, and thus a role of AGP and its 3 glycoforms is suggested in the pathogenesis of Graves' disease.

Cited by 9 publications

References 32 publications

Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Lc-ms/ms Protein Profiling in Healthy Subjects

Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Lc-ms/ms Protein Profiling in Healthy Subjects

Serum levels of alpha‐1 acid glycoprotein and pentraxin 3 in patients with Behçet's disease and relationship with disease activity

Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata

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Long-term Pathologic Changes of α1-Acid Glycoprotein (orosomucoid) Glycoforms in Autoimmune Thyroid Disease

Abstract: Patients with autoimmune Graves' disease changed their relationship to AGP, and thus a role of AGP and its 3 glycoforms is suggested in the pathogenesis of Graves' disease.

Cited by 9 publications

References 32 publications

Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Lc-ms/ms Protein Profiling in Healthy Subjects

Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Lc-ms/ms Protein Profiling in Healthy Subjects

Serum levels of alpha‐1 acid glycoprotein and pentraxin 3 in patients with Behçet's disease and relationship with disease activity

Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata

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Long-term Pathologic Changes of α₁-Acid Glycoprotein (orosomucoid) Glycoforms in Autoimmune Thyroid Disease