Long-Term outcomes and modes of death of patients treated with nonthoracotomy implantable defibrillators

Kim, Soo G.; Roth, James A.; Fisher, John D.; Chung, Julie; Nagabhairu, Revathi; Ferrick, Kevin J.; Ben-Zur, Uri; Gross, Jay N.; Furman, Seymour

doi:10.1016/s0002-9149(99)80768-1

Cited by 13 publications

(1 citation statement)

References 14 publications

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“…Other studies have found a low left ventricular ejection fraction to be predictive for shock occurrence (6, 12,lS). As in previous studies (6,8,9,12,14), w e found the most important predictor of cardiac death to be a left ventricular ejection fraction below 30%.…”

Section: Clinical Predictors Of Appropriate Therapy and Survival In Psupporting

confidence: 71%

Long-term Follow-up of Patients Treated with Implantable Cardioverter Defibrillators in a Danish Centre: Occurrence of ICD Therapy and Patient Survival

Nielsen¹,

Mortensen²,

Pedersen³

1997

Scandinavian Cardiovascular Journal

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The aim of the this prospective follow-up study was to evaluate long-term survival and implantable cardioverter-defibrillator (ICD) therapy for ventricular tachyarrhythmias in patients treated with an ICD in a Danish centre. A total of 140 consecutive patients (112 men), of which 70.7% had coronary artery disease, received an ICD at Skejby University Hospital between March 1989 and October 1996. Mean age was 55.6 +/- 14.6 years (range 14-78 years). After implantation, 136 of the patients were followed for a median (range) of 17.7 (0.4-74.1) months. Survival, mode of death and incidence of appropriate ICD therapy and therapy due to potential life-threatening ventricular tachyarrhythmia were the main outcome measures. Kaplan-Meier plots representing total survival, cardiac death, sudden cardiac death and first episode of ICD therapy are presented. After 1, 2, 3 and 4 years, respectively, the cumulative incidences of death were 9, 18, 20 and 24%, of cardiac death 4, 11, 14 and 18%, and of sudden cardiac death 2, 3, 6 and 6%. The cumulative incidences of appropriate therapy after 1, 2, 3 and 4 years were 47, 56, 66 and 80%, respectively. The cumulative incidences of cardiac death after the first episode of appropriate therapy were 9, 11, 15 and 20% after 1, 2, 3 and 4 years, respectively. The occurrence of ICD therapy and patient survival in the present study population treated with ICD at a Danish centre was comparable to results published previously from other larger centres. The rate of sudden cardiac death was low and most of our patients received appropriate ICD therapy during follow-up, indicating correct patient selection and probable benefit of the ICD device.

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Section: Clinical Predictors Of Appropriate Therapy and Survival In Psupporting

confidence: 71%

Long-term Follow-up of Patients Treated with Implantable Cardioverter Defibrillators in a Danish Centre: Occurrence of ICD Therapy and Patient Survival

Nielsen¹,

Mortensen²,

Pedersen³

1997

Scandinavian Cardiovascular Journal

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Predictors of ventricular tachycardia recurrence in 100 patients receiving tiered therapy defibrillators

Costeas

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et al. 2000

Clinical Cardiology

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SummaryBackground andhypothesis: Programmed electrical stimulation (PES) is a time-honored diagnostic tool in patients with ventricular tachyarrhythmias. The response to PES can be used to assess efficacy of pharmacologic or electrical therapy, as well as to obtain prognostic information. Reproducible induction of ventricular tachycardia with invasive electrophysiologic testing, or stimulation through defibrillator lead systems, can help optimize antiarrhythmic drug therapy and device programming during clinical follow-up.Methods: We present our experience with 100 patients who had inducible sustained monomorphic ventricular tachycardia (SMVT) during invasive PES at baseline, and received a thirdgeneration implantable cardioverter-defibrillator (ICD) alone, or in combination with antiarrhythmic drug therapy. Noninvasive programmed stimulation (NIPS) was performed prior to hospital discharge in 61 patients.Results: The inducibility of SMVT was concordant between the invasive study and NIPS in a subgroup of 40 (82%) patients who had invasive PES on the same drug regimen. During a mean follow-up of 16 months, there were 12 nonarrhythmic deaths and recurrence of spontaneous SMVT in 36 (40%) of the surviving patients. Using a Cox proportional hazards model, the following variables were associated with early arrhythmia recurrence: persistent inducibility of SMVT during the NIPS session (relative risk 1 1, range 2.6-47); induction

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Predictors of Long-Term Survival in Patients With Malignant Ventricular Arrhythmias

Gomes

Mehta

et al. 1997

The American Journal of Cardiology

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Long-Term outcomes and modes of death of patients treated with nonthoracotomy implantable defibrillators

Cited by 13 publications

References 14 publications

Long-term Follow-up of Patients Treated with Implantable Cardioverter Defibrillators in a Danish Centre: Occurrence of ICD Therapy and Patient Survival

Long-term Follow-up of Patients Treated with Implantable Cardioverter Defibrillators in a Danish Centre: Occurrence of ICD Therapy and Patient Survival

Predictors of ventricular tachycardia recurrence in 100 patients receiving tiered therapy defibrillators

Predictors of Long-Term Survival in Patients With Malignant Ventricular Arrhythmias

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