Long-term Outcome of Schilder Disease Treated With Interferon-β

Abstract

Schilder disease, also termed diffuse myelinoclastic sclerosis, is characterized by a large demyelinating lesion involving 1 or both sides of the centrum semiovale of the cerebral hemispheres. It often presents with tumorlike features and poses a diagnostic challenge. Schilder disease can be monophasic or relapsing, and disease-modifying therapy for the latter scenario is largely empirical. Here, we report a 14-year-old girl with relapsing Schilder disease within 1 year after disease onset. She has been followed-up for nearly 10 years and remains in sustained remission ever since interferon-b therapy was prescribed after the second attack. In this case study, it is suggested that interferon-b may induce long-term remission in relapsing Schilder disease and is therefore worth considering in this regard.

Tumefactive Demyelinating Lesions in Children: A Rare Case of Conus Medullaris Involvement and Systematic Review of the Literature

“…Although the presence of multiple tumefactive lesions was not generally associated with a diagnosis of multiple sclerosis, the presence of non-tumefactive lesions was associated with such a diagnosis in 10 of 11 children. Consistent with previous reports, 36 ,49 evaluation of lesion location demonstrated frontoparietal involvement in most cases, whereas cerebellar, brainstem, and spinal cord involvement was uncommon.…”

“…The clinical, demographic, and radiologic features of this pediatric cohort are illustrated in (Figure 3 9 –48 ). A detailed summary of each case is shown in Online Appendix Table 1.…”

Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets

“…It plays a critical role in the pro-inflammatory immune responses to viral infections [ 33 , 34 ]. The IFN- cytokine is used in treatment of many diseases, including multiple sclerosis and cancer (see, e.g., [ 35 , 36 , 37 ]), as well as in viral infections [ 38 , 39 ].…”