Long-term outcome of peritoneal dialysis in infants

Renal Replacement Therapy in Infants with Chronic Renal Failure in the First Year of Life

“…Several studies showed that extrarenal comorbidity had the most important influence on outcome (17,30,31). In the study of Shroff et al (20), nonrenal comorbidity was a significant predictor of poor outcome with a 7.5 times increased risk for death.…”

Long-term outcome of chronic dialysis in children

“…The importance of both renal comorbidity, i.e. anuria, and non-renal co-morbidity, including pulmonary hypoplasia and severe developmental delay as significant risk factors for increased mortality in infants and young children, has been identified by analysis of NAPRTCS data [9] and in smaller studies [14][15][16]. The Italian multicentre study also reported a higher proportion of deaths in the presence of non-renal disease [12].…”

“…Although the NAPRTCS registry data show a decrease in height SDS, for those on dialysis, from −1.64 [standard error (SE, 0.03)], to −1.71 (0.04) at 1 year and −1.84 (0.05) at 2 years [2], we have demonstrated that an early and more intensive approach to feeding maintains or even improves height SDS [8,14,51]. In our experience, 89% of children that presented before they were 2 years old with CKD stages 4-5, who subsequently underwent dialysis, required enteral feeding.…”

Growth hormone treatment of infants with chronic kidney disease: requirement, efficacy, and safety

“…In these retrospective studies, growth in a total of 162 patients with pre-terminal chronic renal failure or requiring dialysis (hemodialysis, peritoneal dialysis) during their first year of life was analyzed [13][14][15][16][17][18]. Conservative treatment for these patients consisted of metabolic control for acidosis, electrolyte and water losses, secondary hyperparathyroidism/renal osteodystrophy (phosphate binders and vitamin D metabolites), and anemia (iron supplements, erythropoietin).…”

“…At first observation, median standardized height was already reduced to −1.8 SD. In three studies involving 42 infants on peritoneal dialysis (PD) a significant increase in standardized height was noted, and median height in these patients improved from −1.8 SD at baseline to −1.0 SD after a median observation period of 9 months [14][15][16]. Noteworthy, approximately two-thirds of the infants included in these studies originated from Finland and suffered from congenital nephrotic syndrome.…”