Long-term Outcome of Daylight Photodynamic Therapy with Amino-5-laevulinate Nanoemulsion vs. Methyl-5-aminolaevulinate for Actinic Keratoses

A randomized, intraindividual, non‐inferiority, Phase III study comparing daylight photodynamic therapy with BF‐200 ALA gel and MAL cream for the treatment of actinic keratosis

“…6,20,27 During follow-up, the overall lesion recurrence was significantly different in favour of BF-200 ALA (19.9% vs. 31.6% for BF-200 ALA and MAL, respectively). 1-year recurrence rates were significantly better for BF-200 ALA (22.1% vs. 36.4%) for moderate lesions, in agreement with findings by Neittaanm€ aki et al 13 Furthermore, the more difficult-to-treat lesions on the scalp displayed significantly lower recurrence rates for BF-200 ALA-treated sides compared with MAL-treated sides (23.4% vs. 43.7%, respectively).…”

“…Studies on dPDT were previously conducted with both MAL cream and BF‐200 ALA gel. In agreement with the superiority of BF‐200 ALA shown in a pivotal trial comparing the two drugs for AK treatment with cPDT, BF‐200 ALA gel (Ameluz ® ) was found to be more effective than MAL cream in natural dPDT in a small single‐centre study . Additionally, BF‐200 ALA was effective in indoor simulated dPDT …”

“…In agreement with the superiority of BF-200 ALA shown in a pivotal trial comparing the two drugs for AK treatment with cPDT, 10 BF-200 ALA gel (Ameluz â ) was found to be more effective than MAL cream in natural dPDT in a small single-centre study. 6,13 Additionally, BF-200 ALA was effective in indoor simulated dPDT. 5 To compare BF-200 ALA gel and MAL cream in dPDT, a study was designed to prove the assumption that BF-200 ALA gel is non-inferior to MAL cream (with a non-inferiority margin of D = À12.5).…”

Long-term Outcome of Low-concentration Hexyl-5-aminolaevulinate Daylight Photodynamic Therapy for Treatment of Actinic Keratoses

“…Long-term clearance is rarely reported in DL-PDT studies. Recently, 62% and 87% mean per-patient lesion clearance was reported for MAL and amino-5-laeuvulinate nanoemulsion (BF-200 ALA) (12). In our current study at 12 months the clearances were 67% for HAL and 66% for MAL, which supports the previous 12-month data with MAL.…”

Photodynamic therapy: A hot topic in dermato-oncology (Review)

“…After 3 months, 84.5% of lesions treated with BF-ALA D-PDT and 74.2% of lesions treated with MAL D-PDT cleared (68). After 12 months, BF-200 ALA D-PDT showed better maintained clearance than MAL D-PDT, the authors therefore concluding that BF-200 ALA shows improved efficacy compared with MAL (69). Hexylaminolaevulinate (HAL) is a long-chained ester of ALA which has better skin penetration than MAL.…”