Long-term optional ingestion of corn oil induces excessive caloric intake and obesity in mice

Takeda, Masami; Imaizumi, Masahiro; Sawano, Shoko; Manabe, Yasuko; Fushiki, Tohru

doi:10.1016/s0899-9007(00)00513-x

Cited by 31 publications

(23 citation statements)

References 25 publications

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“…Overconsumption of dietary fat greatly contributes to the current epidemic of obesity. Mice to which corn oil was given as an optional supplement to standard laboratory chow over a long period exhibit a chronic excessive caloric intake and develop obesity (34). Our data raise the possibility that CD36-mediated fat perception in food may contribute to the obesity risk.…”

Section: Figurementioning

confidence: 76%

CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions

Laugerette¹

2005

Journal of Clinical Investigation

560

511

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Rats and mice exhibit a spontaneous attraction for lipids. Such a behavior raises the possibility that an orosensory system is responsible for the detection of dietary lipids. The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (LCFAs) and is found in lingual papillae in the rat. To explore this hypothesis further, experiments were conducted in rats and in wild-type and CD36-null mice. In mice, RT-PCR experiments with primers specific for candidate lipid-binding proteins revealed that only CD36 expression was restricted to lingual papillae although absent from the palatal papillae. Immunostaining studies showed a distribution of CD36 along the apical side of circumvallate taste bud cells. CD36 gene inactivation fully abolished the preference for LCFA-enriched solutions and solid diet observed in wild-type mice. Furthermore, in rats and wild-type mice with an esophageal ligation, deposition of unsaturated LCFAs onto the tongue led to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions. These findings demonstrate that CD36 is involved in oral LCFA detection and raise the possibility that an alteration in the lingual fat perception may be linked to feeding dysregulation.

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Section: Figurementioning

confidence: 76%

CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions

Laugerette¹

2005

Journal of Clinical Investigation

560

511

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“…11 It has been reported that ddY mice show increased body weight and liver weight in response to 20% sucrose supplementation. 12 We found that ddY mice possess guanine Ϫ468 bp in the SREBP-1c promoter and show hepatic steatosis when fed either sucrose supplementation or an HF diet (Yamazaki et al, unpublished observation).…”

mentioning

confidence: 91%

Fish oil prevents sucrose-induced fatty liver but exacerbates high-safflower oil-induced fatty liver in ddy mice

Yamazaki

Nakamori²,

Sasaki³

et al. 2007

Hepatology

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Diets high in sucrose/fructose or fat can result in hepatic steatosis (fatty liver). We analyzed the effects of dietary fish oil on fatty liver induced by sucrose, safflower oil, and butter in ddY mice. In experiment I, mice were fed a high-starch diet [70 energy% (en%) starch] plus 20% (wt/wt) sucrose in the drinking water or fed a high-safflower oil diet (60 en%) for 11 weeks. As a control, mice were fed a high-starch diet with drinking water. Fish oil (10 en%) was either supplemented or not. Mice supplemented with sucrose or fed safflower oil showed a 1.7-fold or 2.2-fold increased liver triglyceride content, respectively, compared with that of control mice. Fish oil completely prevented sucrose-induced fatty liver, whereas it exacerbated safflower oil-induced fatty liver. Sucrose increased SREBP-1c and target gene messenger RNAs (mRNAs), and fish oil completely inhibited these increases. In experiment II, mice were fed a high-safflower oil or a high-butter diet, with or without fish oil supplementation. Fish oil exacerbated safflower oilinduced fatty liver but did not affect butter-induced fatty liver. Fish oil increased expression of peroxisome proliferator-activated receptor gamma (PPAR␥) and target CD36 mRNA in safflower oil-fed mice. These increases were not observed in sucrose-supplemented or butter-fed mice. Conclusion: The effects of dietary fish oil on fatty liver differ according to the cause of fatty liver; fish oil prevents sucrose-induced fatty liver but exacerbates safflower oil-induced fatty liver. The exacerbation of fatty liver may be due, at least in part, to increased expression of liver PPAR␥.

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“…On peut penser que ce comportement stéréotypé peut conduire à une obésité quand les lipides consommés satisfont à la fois des besoins hédo-niques et métaboliques. On constate en effet que des souris deviennent obèses quand on leur propose systématiquement de l'huile de maïs comme supplément optionnel à leur régime alimentaire habituel [34]. Cette préfé-rence s'inscrivant dans la durée, on peut se demander s'il existe une addiction aux lipides chez le rongeur.…”

Section: Resultsunclassified

Perception gustative des lipides alimentaires : paradigme et paradoxes

Gaillard

Passilly-Degrace

Besnard

2008

OCL

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Long-term optional ingestion of corn oil induces excessive caloric intake and obesity in mice

Cited by 31 publications

References 25 publications

CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions

CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions

Fish oil prevents sucrose-induced fatty liver but exacerbates high-safflower oil-induced fatty liver in ddy mice

Perception gustative des lipides alimentaires : paradigme et paradoxes

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