Long-term Observations of Proton-Irradiated Monkey Eyes

Proton therapy for uveal melanomas and other eye lesions

“…A marked effect of fractionation was seen: 125 Gy/5 fx produced the same effect at 24 hours and at 1 year as 30 Gy in a single pulse [19]. Chorioretinal changes persisted within the irradiated area at 42 to 51 months, while normal retinal architecture was preserved immediately outside the discrete retinal scar produced by the proton beam [20].…”

Proton therapy for uveal melanomas and other eye lesions

“…A marked effect of fractionation was seen: 125 Gy/5 fx produced the same effect at 24 hours and at 1 year as 30 Gy in a single pulse [19]. Chorioretinal changes persisted within the irradiated area at 42 to 51 months, while normal retinal architecture was preserved immediately outside the discrete retinal scar produced by the proton beam [20].…”

Proton Beam Irradiation of Uveal Melanomas: The First 30 Years The Weisenfeld Lecture

“…65 Further, normal retinal architecture as close as 1 mm from the edge of such lesions was observed over 3 years after proton irradiation. 66 Once the concept of the utility of proton beam irradiation for ocular melanoma had been established, further research was performed to improve the accuracy with which this therapy could be delivered. This concept was substantiated by the results we observed after treatment in our earliest patients.…”

Effects and recurrence of proton beam therapy for retinal detachment due to choroidal hemangioma in Sturge–Weber syndrome patients: A case report

“…[ 7 ] Radiation therapy is believed to reduce the size of vascular hemangiomas by inhibiting the formation of thrombi that occlude tumor vessels and the proliferation of endothelial cells within the tumor, which in turn reduces exudate and improves retinal detachment. [ 17 , 21 ]…”

Proton therapy for uveal melanomas and other eye lesions

“…A marked effect of fractionation was seen: 125 Gy/5 fx produced the same effect at 24 hours and at 1 year as 30 Gy in a single pulse [19]. Chorioretinal changes persisted within the irradiated area at 42 to 51 months, while normal retinal architecture was preserved immediately outside the discrete retinal scar produced by the proton beam [20].…”

Proton Beam Irradiation of Uveal Melanomas: The First 30 Years The Weisenfeld Lecture

“…65 Further, normal retinal architecture as close as 1 mm from the edge of such lesions was observed over 3 years after proton irradiation. 66 Once the concept of the utility of proton beam irradiation for ocular melanoma had been established, further research was performed to improve the accuracy with which this therapy could be delivered. This concept was substantiated by the results we observed after treatment in our earliest patients.…”

Effects and recurrence of proton beam therapy for retinal detachment due to choroidal hemangioma in Sturge–Weber syndrome patients: A case report

“…[ 7 ] Radiation therapy is believed to reduce the size of vascular hemangiomas by inhibiting the formation of thrombi that occlude tumor vessels and the proliferation of endothelial cells within the tumor, which in turn reduces exudate and improves retinal detachment. [ 17 , 21 ]…”

Proton therapy for uveal melanomas and other eye lesions

“…A marked effect of fractionation was seen: 125 Gy/5 fx produced the same effect at 24 hours and at 1 year as 30 Gy in a single pulse [19]. Chorioretinal changes persisted within the irradiated area at 42 to 51 months, while normal retinal architecture was preserved immediately outside the discrete retinal scar produced by the proton beam [20].…”

Proton Beam Irradiation of Uveal Melanomas: The First 30 Years The Weisenfeld Lecture

“…65 Further, normal retinal architecture as close as 1 mm from the edge of such lesions was observed over 3 years after proton irradiation. 66 Once the concept of the utility of proton beam irradiation for ocular melanoma had been established, further research was performed to improve the accuracy with which this therapy could be delivered. This concept was substantiated by the results we observed after treatment in our earliest patients.…”

Effects and recurrence of proton beam therapy for retinal detachment due to choroidal hemangioma in Sturge–Weber syndrome patients: A case report

“…[ 7 ] Radiation therapy is believed to reduce the size of vascular hemangiomas by inhibiting the formation of thrombi that occlude tumor vessels and the proliferation of endothelial cells within the tumor, which in turn reduces exudate and improves retinal detachment. [ 17 , 21 ]…”