Long-Term Neuropsychological Outcome After Traumatic Brain Injury

Millis, Scott R.; Rosenthal, Mitchell; Novack, Thomas A.; Sherer, Mark; Nick, Todd G.; Kreutzer, Jeffery S.; High, Walter M.; Ricker, Joseph H.

doi:10.1097/00001199-200108000-00005

Cited by 390 publications

(235 citation statements)

References 20 publications

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“…First, since individuals with TBI are not a heterogeneous group in terms of injury severity and degree of impairment caused by TBI, HLM permits the study of life satisfaction trajectories by TBI severity (e.g., mild, moderate, and severe). Particular attention should be paid to cognitive functioning that appears to show improvement over time (e.g., over a 5-year period: cognitive speed, visuoconstruction, and verbal memory; Millis et al, 2001). The possible relations of cognitive changes to functional ability, community integration, and social mobility warrant rigorous scrutiny with the best available and contemporary methods.…”

Section: Discussionmentioning

confidence: 99%

Trajectories of life satisfaction in the first 5 years following traumatic brain injury.

Resch¹,

Villarreal²,

Johnson³

et al. 2009

Rehabilitation Psychology

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Objectives:The trajectories of life satisfaction for 609 individuals who sustained a traumatic brain injury (TBI) were studied. Hierarchical linear modeling analysis examined individual level growth trends over the first 5 years following TBI using gender, functional independence, age, and time to estimate life satisfaction trajectories. Measures: Participants completed the Functional Independence Measure and the Life Satisfaction Inventory at years 1, 2, 4, and 5 after sustaining TBI. Results: Participants who reported higher functional independence at year 1 also had higher life satisfaction at year 1. Participants with lower functional independence across the 5-year period had life satisfaction trajectories that decreased at significantly greater rates than the individuals with more functional independence. The life satisfaction trajectory declined for the sample, but participants reporting lower cognitive and motor functional independence had significantly greater declines in life satisfaction trajectories. Age and gender were not significant factors in predicting life satisfaction trajectories following TBI. Implications: Individuals with greater cognitive and motor impairments following TBI are likely to experience significant declines in life satisfaction within 5 years of living with TBI.

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Section: Discussionmentioning

confidence: 99%

Trajectories of life satisfaction in the first 5 years following traumatic brain injury.

Resch¹,

Villarreal²,

Johnson³

et al. 2009

Rehabilitation Psychology

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show abstract

“…The most commonly reported ailments by patients following TBI are cognitive in nature and consist of persistent deficits in both learning and memory, which are manifest in the inability to acquire new information (Horneman and Emanuelson, 2009). Thus these individuals tend to become easily confused and forgetful, and many complain of an inability to organize thoughts or acquire spatial awareness, which subsequently delays their reintegration into society (Binder, 1996;Millis et al, 2001). The acute and chronic medical and rehabilitative care required because of these TBI-induced deficits, along with the loss of productivity, results in injury-related costs that exceed $50 billion per year (Max et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Traumatic Brain Injury-Induced Cognitive and Histological Deficits Are Attenuated by Delayed and Chronic Treatment with the 5-HT_1A-Receptor Agonist Buspirone

Olsen

Sozda

Cheng

et al. 2012

Journal of Neurotrauma

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The aim of this study was to evaluate the potential efficacy of the serotonin 1A (5-HT 1A ) receptor agonist buspirone (BUS) on behavioral and histological outcome after traumatic brain injury (TBI). Ninety-six isofluraneanesthetized adult male rats were randomized to receive either a controlled cortical impact or sham injury, and then assigned to six TBI and six sham groups receiving one of five doses of BUS (0.01, 0.05, 0.1, 0.3, or 0.5 mg/kg) or saline vehicle (VEH, 1.0 mL/kg). Treatments began 24 h after surgery and were administered intraperitoneally once daily for 3 weeks. Motor function (beam-balance/beam-walk tests) and spatial learning/memory (Morris water maze) were assessed on post-operative days 1-5 and 14-19, respectively. Morphologically intact CA1/ CA3 cells and cortical lesion volume were quantified at 3 weeks. No differences were observed among the BUS and VEH sham groups in any end-point measure and thus the data were pooled. Regarding the TBI groups, repeated-measures ANOVAs revealed that the 0.3 mg/kg dose of BUS enhanced cognitive performance relative to VEH and the other BUS doses ( p < 0.05), but did not significantly impact motor function. Moreover, the same dose conferred selective histological protection as evidenced by smaller cortical lesions, but not greater CA1/ CA3 cell survival. No significant behavioral or histological differences were observed among the other BUS doses versus VEH. These data indicate that BUS has a narrow therapeutic dose response, and that 0.3 mg/kg is optimal for enhancing spatial learning and memory in this model of TBI. BUS may have potential as a novel pharmacotherapy for clinical TBI.

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“…[6][7][8][9] Though functional connectivity of the DMN has been studied widely in a variety of clinical populations, a relatively small literature base exists in moderate or severe traumatic brain injury (TBI), for which longterm neuropsychological outcomes are heterogeneous and therefore difficult to predict. 10,11 The delineation of intrinsic connectivity alterations after TBI may shed light on enduring functional changes affecting cognitive status in the remote future.…”

mentioning

confidence: 99%

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

Venkatesan

Dennis

Hillary

2015

Journal of Neurotrauma

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Whereas traumatic brain injury (TBI) results in widespread disruption of neural networks, changes in regional resting-state functional connectivity patterns after insult remain unclear. Specifically, little is known about the chronology of emergent connectivity alterations and whether they persist after a critical recovery window. We used resting-state functional magnetic resonance imaging and seed-voxel correlational analyses in both cross-sectional and longitudinal designs to probe intrinsic connectivity patterns involving the posterior cingulate cortex (PCC) and hippocampi, regions shown to be important in the default mode network (DMN) and vulnerable to neuropathology. A total of 22 participants in the chronic stage of moderateto-severe TBI and 18 healthy controls were included for cross-sectional study. Longitudinal analyses included 13 individuals in the TBI group for whom data approximately 3 months after injury (subacute) were available. Overall, results indicated dissociable connectivity trajectories of the PCC and hippocampi during recovery from TBI, with PCC alterations characterized by early hypersynchrony with the anterior DMN that is gradually reduced, and hippocampal changes marked by increasing synchrony with proximal cortex and subcortex. The PCC also showed increasing antiphase synchrony with posterior attentional regions, and the hippocampi showed decreasing antiphase synchrony with frontal attentional regions. Antiphase synchrony of the hippocampus and dorsolateral prefrontal cortex at the subacute stage of TBI was positively associated with attentional performance on neuropsychological tests at both the subacute and chronic stages. Our findings highlight the heterogeneity of regional whole-brain connectivity changes after TBI, and suggest that residual connectivity alterations exist in the clinically stable phase of TBI. Parallels between the chronicity of the observed effects and findings in neurodegenerative disease are discussed in the context of potential long-term outcomes of TBI.

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Long-Term Neuropsychological Outcome After Traumatic Brain Injury

Cited by 390 publications

References 20 publications

Trajectories of life satisfaction in the first 5 years following traumatic brain injury.

Trajectories of life satisfaction in the first 5 years following traumatic brain injury.

Traumatic Brain Injury-Induced Cognitive and Histological Deficits Are Attenuated by Delayed and Chronic Treatment with the 5-HT_1A-Receptor Agonist Buspirone

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

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Long-Term Neuropsychological Outcome After Traumatic Brain Injury

Cited by 390 publications

References 20 publications

Trajectories of life satisfaction in the first 5 years following traumatic brain injury.

Trajectories of life satisfaction in the first 5 years following traumatic brain injury.

Traumatic Brain Injury-Induced Cognitive and Histological Deficits Are Attenuated by Delayed and Chronic Treatment with the 5-HT1A-Receptor Agonist Buspirone

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

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Product

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Traumatic Brain Injury-Induced Cognitive and Histological Deficits Are Attenuated by Delayed and Chronic Treatment with the 5-HT_1A-Receptor Agonist Buspirone