Long-term maintenance of multidrug-resistant Escherichia coli carried by vampire bats and shared with livestock in Peru

Benavides, Julio A.; Godreuil, Sylvain; Opazo-Capurro, Andrés; Mahamat, Oumar Ouchar; Falcón, Néstor; Oravcova, Katarina; Streicker, Daniel G.; Shiva, Carlos

doi:10.1016/j.scitotenv.2021.152045

Cited by 30 publications

(45 citation statements)

References 54 publications

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“…Further, it has been suggested that vultures and other scavengers that feed on livestock carcasses might ingest ARB if they are present in such carcasses ( Blanco and Bautista, 2020 ). Besides, bats, feeding on alive farm animals, contain in their microbiomes E. coli isolates belonging to the most prevalent sequence types causing infections worldwide, as well as several of the ESBLs that are of particular concern at hospitals ( Benavides et al., 2022 ).…”

Section: Local Transmission Of Antibiotic Resistance Through Wildlifementioning

confidence: 99%

Wildlife and Antibiotic Resistance

Laborda

Sanz-García

Ochoa-Sánchez

et al. 2022

Front. Cell. Infect. Microbiol.

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Antibiotic resistance is a major human health problem. While health care facilities are main contributors to the emergence, evolution and spread of antibiotic resistance, other ecosystems are involved in such dissemination. Wastewater, farm animals and pets have been considered important contributors to the development of antibiotic resistance. Herein, we review the impact of wildlife in such problem. Current evidence supports that the presence of antibiotic resistance genes and/or antibiotic resistant bacteria in wild animals is a sign of anthropic pollution more than of selection of resistance. However, once antibiotic resistance is present in the wild, wildlife can contribute to its transmission across different ecosystems. Further, the finding that antibiotic resistance genes, currently causing problems at hospitals, might spread through horizontal gene transfer among the bacteria present in the microbiomes of ubiquitous animals as cockroaches, fleas or rats, supports the possibility that these organisms might be bioreactors for the horizontal transfer of antibiotic resistance genes among human pathogens. The contribution of wildlife in the spread of antibiotic resistance among different hosts and ecosystems occurs at two levels. Firstly, in the case of non-migrating animals, the transfer will take place locally; a One Health problem. Paradigmatic examples are the above mentioned animals that cohabit with humans and can be reservoirs and vehicles for antibiotic resistance dissemination. Secondly, migrating animals, such as gulls, fishes or turtles may participate in the dissemination of antibiotic resistance across different geographic areas, even between different continents, which constitutes a Global Health issue.

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Section: Local Transmission Of Antibiotic Resistance Through Wildlifementioning

confidence: 99%

Wildlife and Antibiotic Resistance

Laborda

Sanz-García

Ochoa-Sánchez

et al. 2022

Front. Cell. Infect. Microbiol.

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“…A third Brazilian study also reported E. coli (n=17) isolates from bats resistant to ampicillin (59%) and amoxicillin (35%) [59]. Two back-toback reports from Peru reported ESBL producing E. coli (n=5 and 18) from bats which showed pan-resistant to amoxicillin, amoxicillin ticarcillin, piperacillin, cefotaxime, and other antibiotics [40,60]. A study from Trinidad reported isolation of E. coli (n=49) from several bat species and found most of them were resistant to erythromycin (71%) and streptomycin (26%) [61].…”

Section: Evidence Of Antibiotic Resistant Gram-negative Bacterial Pat...mentioning

confidence: 94%

“…All the 5 ESBL producing E. coli isolates expressed plasmid blaCTX-M-15 genes showing resistance towards β-lactam antibiotics. Two years later, the authors reported isolation of several genes such as blaCTX-M-15 (39%), blaCTX-M-3 (11.11%) blaCTX-M-55 (44.44%), blaCTX-M-65 (5.55%), blaTEM-1B-like (66.66%), and blaTEM-176 (28%), responsible for ESBL production [60].…”

Section: Esbl Producing and Colistin Resistant Enterobactersmentioning

confidence: 99%

Evidence of Antimicrobial Resistance in Bats and Its Planetary Health Impact for Surveillance of Zoonotic Spillover Events: A Scoping Review

Devnath¹,

Karah²,

Graham³

et al. 2022

Preprint

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As a result of the COVID-19 pandemic, as well as other outbreaks such as SARS and Ebola, bats are recognized as a critical species for mediating zoonotic infectious disease spillover events. While there is a growing concern of increased antimicrobial resistance (AMR) globally during this pandemic, knowledge of AMR circulating between bats and humans is limited. In this paper, we have reviewed the evidence of AMR in bats and discussed the planetary health aspect of AMR to elucidate how this is associated with the emergence, spread and persistence of antibiotic resistance at the human-animal interface. The presence of clinically significant resistant bacteria in bats and wild life has reflective and broad impact on zoonotic pandemic surveillance, disease transmission and treatment modalities. We searched MEDLINE through PubMed and Google Scholar to retrieve relevant studies (n=38) that provided data on resistant bacteria in bats till September 30, 2022. There is a substantial variability in the results from studies measuring the prevalence of AMR based on geographic location, bat types and time. We found all major groups of gram positive and gram negative bacteria in bats which are resistant to commonly used antibiotics. The most alarming issue is- recent studies have increasingly identified Methicillin Resistant Staphylococcus aureus (MRSA), ESBL producing and Colistin resistant Enterobacteriaceae in samples from bats. This evidence of superbugs abundance in both humans and wild mammals like bats, could facilitate a greater understanding of which specific pathways of exposure should be targeted. We believe that these data will also facilitate future pandemic prepareness as well as global AMR containment during the pandemic events and beyond.

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“…Bats have adapted to living in close proximity to human connected with their life cycle and habitat. Multi-resistant bacterial strains were isolated and identified in bats ( García et al, 2020 ; Nowakiewicz et al, 2020 ; McDougall et al, 2021 ; Obodoechi et al, 2021 ; Benavides et al, 2022 ). Although different bacteria are important in terms of antimicrobial resistance in humans, extended-spectrum beta-lactamases (ESBL) producing Gram-negative bacteria like E. coli are considered key indicator pathogens to study the evolution of multi-resistant bacteria in the environment and wildlife ( Radhouani et al, 2014 ).…”

Section: Antimicrobial Resistance In Batsmentioning

confidence: 99%

“…Although different bacteria are important in terms of antimicrobial resistance in humans, extended-spectrum beta-lactamases (ESBL) producing Gram-negative bacteria like E. coli are considered key indicator pathogens to study the evolution of multi-resistant bacteria in the environment and wildlife ( Radhouani et al, 2014 ). ESBL-producing E. coli isolates from bats are reported worldwide ( Nowakiewicz et al, 2020 ; McDougall et al, 2021 ; Obodoechi et al, 2021 ; Benavides et al, 2022 ). ESBLs are enzymes that confer resistance to most beta-lactam antibiotics, including penicillins and cephalosporins.…”

Section: Antimicrobial Resistance In Batsmentioning

confidence: 99%

An overview of bats microbiota and its implication in transmissible diseases

Federici

Masulli²,

Laurenzi³

et al. 2022

Front. Microbiol.

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Recent pandemic events have raised the attention of the public on the interactions between human and environment, with particular regard to the more and more feasible transmission to humans of micro-organisms hosted by wild-type species, due to the increasing interspecies contacts originating from human’s activities. Bats, due to their being flying mammals and their increasing promiscuity with humans, have been recognized as hosts frequently capable of transmitting disease-causing microorganisms. Therefore, it is of considerable interest and importance to have a picture as clear as possible of the microorganisms that are hosted by bats. Here we focus on our current knowledge on bats microbiota. We review the most recent literature on this subject, also in view of the bat’s body compartments, their dietary preferences and their habitat. Several pathogenic bacteria, including many carrying multidrug resistance, are indeed common guests of these small mammals, underlining the importance of preserving their habitat, not only to protect them from anthropogenic activities, but also to minimize the spreading of infectious diseases.

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Long-term maintenance of multidrug-resistant Escherichia coli carried by vampire bats and shared with livestock in Peru

Cited by 30 publications

References 54 publications

Wildlife and Antibiotic Resistance

Wildlife and Antibiotic Resistance

Evidence of Antimicrobial Resistance in Bats and Its Planetary Health Impact for Surveillance of Zoonotic Spillover Events: A Scoping Review

An overview of bats microbiota and its implication in transmissible diseases

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