2018
DOI: 10.18632/aging.101583
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Abstract: Age-related chronic inflammation is a major risk factor for the incidence and prevalence of age-related diseases, including infectious and neurodegenerative diseases. We previously reported that a lactic acid bacteria, Lactobacillus paracasei KW3110, activated macrophages and suppressed inflammation in mice and humans. In this study, we investigated whether long-term intake of heat-killed L. paracasei KW3110 modulated age-related inflammation and altered the gut microbiota in physiologically aged mice. Compare… Show more

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Cited by 33 publications
(26 citation statements)
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References 68 publications
(57 reference statements)
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“…In addition, the authors demonstrated that T-cell activations and glaucomatous neurodegeneration were abolished in GF mice, strengthening the hypothesis that a bacteria-sensitized T-cell responses underly the pathogenesis of glaucoma [237]. In line with these data, long-term intake of Lactobacillus paracasei KW3110 has been associated with a more abundance of beneficial gut bacteria and a reduction of the age-related immune dysfunctions, i.e., lowered expansion of pro-inflammatory T cells and serum cytokines [238]. Instead, this probiotic treatment determined a reduction of the Firmicutes to Bacteroidetes ratio, demonstrated by increased Bifidobacteriaceae and decreased Streptococcaceae families.…”
Section: Human Disease N-3 Pufas and Gut Microbiotamentioning
confidence: 61%
“…In addition, the authors demonstrated that T-cell activations and glaucomatous neurodegeneration were abolished in GF mice, strengthening the hypothesis that a bacteria-sensitized T-cell responses underly the pathogenesis of glaucoma [237]. In line with these data, long-term intake of Lactobacillus paracasei KW3110 has been associated with a more abundance of beneficial gut bacteria and a reduction of the age-related immune dysfunctions, i.e., lowered expansion of pro-inflammatory T cells and serum cytokines [238]. Instead, this probiotic treatment determined a reduction of the Firmicutes to Bacteroidetes ratio, demonstrated by increased Bifidobacteriaceae and decreased Streptococcaceae families.…”
Section: Human Disease N-3 Pufas and Gut Microbiotamentioning
confidence: 61%
“…Another recent study shows that modifying the gut microbiome by feeding mice L.paracasei KW3110 demonstrates favorable changes in retinal function and morphology on the aging retina. (19) These studies lay the groundwork for the connection between the enteric microbiome and the retina; however, these investigations did not reveal if the microbiota or its metabolites may alter the retinal gene expression. RNA-seq is a revolutionary technique that can generate very precise results to study the entire transcriptome of the tissue.…”
Section: Discussionmentioning
confidence: 99%
“…KW3110 was previously reported to activate macrophages by interacting with gut immune cells and promoting cytokine production, including IL-10 [ 10 , 13 , 20 ]. It has also been reported that KW3110 suppresses the level of pro-inflammatory cytokines such as IL-1β in the serum of aged mice or the retina of blue-light exposure-induced mice [ 13 , 14 ]. These results suggest that KW3110 ameliorates IL-1β production in inflammatory-stressed immune cells through the IL-10 signaling pathway in both mice and humans ( Fig 7 ).…”
Section: Discussionmentioning
confidence: 99%
“…KW3110 was shown to activate M2 macrophages with anti-inflammatory reactions, and induce the production of anti-inflammatory cytokine interleukin (IL)-10 [ 13 ]. In addition, KW3110 mitigated aging-related chronic inflammation and blue-light exposure-induced retinal inflammation in mice, at least partially through activating immune cells and reducing pro-inflammatory cytokine production, such as IL-1β [ 13 , 14 ]; however, the mechanism underlying the anti-inflammatory effects of KW3110 remains unclear.…”
Section: Introductionmentioning
confidence: 99%