Long-term in vivo evolution of high-purity Mg screw degradation — Local and systemic effects of Mg degradation products

Yu, Yiqiang; Lü, Hua; Sun, Jiao

doi:10.1016/j.actbio.2018.02.023

Cited by 87 publications

(57 citation statements)

References 44 publications

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“…The film gradually transforms into soluble MgCl 2 which can be observed from Figure a, thus accelerating hydrogen evolution (Cao, Song, & Atrens, ; Thomas, Medhekar, Frankel, & Birbilis, ). During in vivo degradation process, Mg(OH) 2 is one of the most common degradation products, along with MgO and hydroxyapatite (HA; Bornapour, Muja, Shum‐Tim, Cerruti, & Pekguleryuz, ; Li, Gu, Lou, & Zheng, ; Shi et al, ; Tie et al, ; Wang et al, ; Yu, Lu, & Sun, ). The modified layer, composed of these corrosion byproducts, can slows down the degradation of the Mg implants in vivo (Bornapour et al, ; Wang, Liu, et al, ; Yu et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…During in vivo degradation process, Mg(OH) 2 is one of the most common degradation products, along with MgO and hydroxyapatite (HA; Bornapour, Muja, Shum‐Tim, Cerruti, & Pekguleryuz, ; Li, Gu, Lou, & Zheng, ; Shi et al, ; Tie et al, ; Wang et al, ; Yu, Lu, & Sun, ). The modified layer, composed of these corrosion byproducts, can slows down the degradation of the Mg implants in vivo (Bornapour et al, ; Wang, Liu, et al, ; Yu et al, ). It is also worth mentioning that the addition of Mg(OH) 2 particles into poly L‐lactic acid (PLLA) coating on Mg–Nd–Zn–Zr alloy was confirmed to show superior cytocompatibility (Shi et al, ), while the HA was beneficial for cell growth and proliferation (Bornapour et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…It is also worth mentioning that the addition of Mg(OH) 2 particles into poly L‐lactic acid (PLLA) coating on Mg–Nd–Zn–Zr alloy was confirmed to show superior cytocompatibility (Shi et al, ), while the HA was beneficial for cell growth and proliferation (Bornapour et al, ). Moreover, the Mg(OH) 2 layer deposited on HP Mg screw surface was proved to affect the pH value in surrounding tissue for the in vivo test, leading to the formation of the HA, which was further conducive to facilitating new bone mineralization and bone repair (Yu et al, ). Therefore, the introduction of biocorrosion byproducts in vivo does not cause adverse effects to the physiological environment.…”

Section: Discussionmentioning

confidence: 99%

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Corrosion behavior and mechanical degradation of as‐extruded Mg–Gd–Zn–Zr alloys for orthopedic application

et al. 2019

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The microstructures, corrosion behavior, and mechanical degradation of the as‐extruded Mg–6.0Gd–0.5Zn–0.4Zr (wt %, GZ60K) and Mg–6.0Gd–1.0Zn–0.4Zr (wt %, GZ61K) alloys were investigated. In both alloys, stacking faults and precipitates are formed in the recrystallized microstructures. The corrosion rate of GZ61K calculated by the hydrogen evolution in simulated body fluid is 0.34 ± 0.13 mm/year, which is lower than that of GZ60K (0.45 ± 0.09 mm/year); and the current density of GZ61K (5.23 ± 1.41 μA cm−2) is much lower than that of GZ60K (11.95 ± 3.37 μA cm−2). The corrosion results indicate GZ61K is more resistant to corrosion than GZ60K, but GZ60K presents more uniform corrosion mode as compared to GZ61K. After immersion in simulated body fluid for 7, 14, and 21 days, a slight decrease in the strength of both alloys is observed. The yield strength half‐life is assessed for mechanical degradation and determined to be 125 and 85 days for GZ60K and GZ61K, respectively. The as‐extruded GZ60K alloy with more uniform corrosion and longer mechanical integrity shows promising potential for orthopedic application.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Corrosion behavior and mechanical degradation of as‐extruded Mg–Gd–Zn–Zr alloys for orthopedic application

et al. 2019

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“…The degradation mechanism of magnesium in aqueous solution can be presented as the following overall reaction [35,36]: A qualitative phase analysis by X-ray diffraction (Figure 4) shows the presence of the single phase of hydroxyapatite (JCPDS 9-432) with different degrees of crystallinity due to the various synthesis conditions. A qualitative phase analysis by X-ray diffraction (Figure 4) shows the presence of the single phase of hydroxyapatite (JCPDS 9-432) with different degrees of crystallinity due to the various synthesis conditions.…”

Section: In Vitro Degradation Testmentioning

confidence: 99%

“…The degradation mechanism of magnesium in aqueous solution can be presented as the following overall reaction [35,36]: XRD patterns of Samples (a)-(e) show that the crystallinity of HA is lower than for the Samples (f) and (g) obtained at higher temperatures (50 • C). The poor crystallinity of the samples does not allow any additional XRD analysis, except the qualitative one.…”

Section: In Vitro Degradation Testmentioning

confidence: 99%

Degradation and In Vivo Response of Hydroxyapatite-Coated Mg Alloy

et al. 2018

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Nowadays there is a need for new generation of biodegradable implants, which should be able to stimulate the healing responses of injured tissues at the molecular level. Magnesium alloys attract great attention as perspective bone implants due to their biocompatibility, physical properties and ability to degrade completely under physiological conditions. The main purpose of this research was assessment of in vitro corrosion and surface morphology after short term in vivo implantation of Mg based implant covered by hydroxyapatite (HA). Mg alloys with the addition of Zr (0.65%), Al (1.85%) and Nd (1.25%) were used. In our work, we propose dipping method for hydroxyapatite coatings formation which has been shown to reduce the corrosion rate of magnesium implants in vivo. Simulated body fluid (SBF; pH 7.4) with ion concentrations approximately equal to those of human blood plasma resembling physiological conditions and citrate buffer with pH 5—simulating inflammation were selected as modelling environments for in vitro degradation test. The rod samples were implanted into the tibia bone of rats and after 1 day and 5 days of implantation were taken out to observe cells adhesion on surface samples. SEM was used to assess surface morphology after in vitro and in vivo tests. SBF solution causes some cracks on the surface of HA coatings, while citrate solution at pH 2 caused complete dissolving of the coating. The HA coating favoured cell adhesion and rapid fibrous tissue formation.

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Investigation on the Mechanical and Corrosion Properties of ZnMnSr Alloys for Biodegradable Orthopedic Implants

et al. 2022

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Zinc‐based alloys with good biocompatibility and corrosion resistance are potential candidates for bioabsorbable implants. Herein, a series of Zn99−x Mn x Sr1 (x = 0.2, 0.3, 0.5, and 0.9 wt%) alloys are investigated using single‐channel vertical extrusion (SCVE) and equal‐channel angular pressing (ECAP) procedures, respectively. It is found that the amount of Mn significantly affects the mechanical properties of alloys. For example, the yield strength, tensile strength, and elongation of Zn–1Sr alloys can reach up to 204.73 ± 3.6 MPa, 244.04 ± 6.45 MPa, and 47.1 ± 3% with 0.99 wt% Mn addition after the SCVE process, which can meet the requirement of orthopedic implant applications. Moreover, the mechanical properties of current alloys are reduced with the combined SCVE + ECAP process, which may be due to more aggregation with the secondary phase within the matrix hcp(Zn). Furthermore, the polarization curves and immersion tests show that the corrosion rate is accelerated for the alloys processed with the combined SCVE + ECAP process (0.34–0.171 mm/y) compared with the ones processed only with SCVE (0.011–0.032 mm/y). The present finds provide a contribution for biodegradable Zn‐based alloys development.

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Long-term in vivo evolution of high-purity Mg screw degradation — Local and systemic effects of Mg degradation products

Cited by 87 publications

References 44 publications

Corrosion behavior and mechanical degradation of as‐extruded Mg–Gd–Zn–Zr alloys for orthopedic application

Corrosion behavior and mechanical degradation of as‐extruded Mg–Gd–Zn–Zr alloys for orthopedic application

Degradation and In Vivo Response of Hydroxyapatite-Coated Mg Alloy

Investigation on the Mechanical and Corrosion Properties of ZnMnSr Alloys for Biodegradable Orthopedic Implants

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